Leroy B Townsend

US Patent:

6342501, Jan 29, 2002

Filed:

Jan 11, 1999

Appl. No.:

09/229391

Inventors:

Leroy B. Townsend - Ann Arbor MI
John C. Drach - Ann Arbor MI

Assignee:

The Regents of the University of Michigan - Ann Arbor MI

International Classification:

C07D48704

US Classification:

514258, 544280

Abstract:

This invention relates to a novel class of 4,5,6,7-substituted non-nucleoside, non-phosphorylatable pyrrolo[2,3-d]pyrimidines which exhibit both significantly lower levels of cytotoxicity and superior antiviral activity than known nucleoside, non-nucleoside, and non-nucleoside, non-phosphorylatable pyrrolo[2,3-d]pyrimidine derivatives, particularly against human DNA viruses such as cytomegalovirus (HCMV) and herpes simplex virus type 1 (HSV-1). These compounds are represented by the following formula: wherein: R is âNR R or oxo; R is âCN, or âCSNR R , or âCONR R ; R is âH, or halo, or âNR R ; wherein R and R are independently âH or an aliphatic group; and R is of the formula R âAr, wherein R is an aliphatic group and Ar is an unsubstituted aryl or an aryl independently substituted with halo, nitro, amino, or aliphatic groups; provided that when R is a âCN or âCSNH , and R is a âH or âNH , and Ar is a âC H or a phenyl substituted with only one aliphatic group, R is an aliphatic group other than methyl such that âR â is not a âCH â; and pharmaceutically acceptable salts, prodrugs and derivatives thereof.

US Patent:

6413938, Jul 2, 2002

Filed:

Aug 25, 1999

Appl. No.:

09/367260

Inventors:

Jeffrey H. Tidwell - Raleigh NC
Stanley D. Chamberlain - Research Triangle Park NC
George A. Freeman - Research Triangle Park NC
Joseph H. Chan - Research Triangle Park NC
George W. Koszalka - Research Triangle Park NC
Leroy B. Townsend - Ann Arbor MI
John C. Drach - Ann Arbor MI

Assignee:

The Regents of the University of Michigan - Ann Arbor MI
Glaxo Wellcome Inc. - Research Triangle Park NC

International Classification:

A61K 3170

US Classification:

514 43, 514394, 514934, 536 241, 536 289, 5483047

Abstract:

According to a first aspect of the invention there is provided compounds of formula (I): wherein: R is hydroxy; O-acetyl; or a halo atom; R is hydroxy; O-acetyl; or a halo atom; R is hydrogen; a halo atom; azido; C alkenyl; C alkynyl; C aryl C alkenyl; C arylC alkynyl âNR R (where R and R may be the same or different and are hydrogen, C alkyl, cyanoC alkyl, hydroxyC alkyl, haloC alkyl, C cycloalkyl, C alkylC cycloalkyl, C alkenyl, C cycloalkylC alkyl, C alkynyl, C aryl, C arylC alkyl, heterocycleC alkyl, C alkylcarbonyl, C arylsulfonyl, C alkysulfonyl, or R R together with the N atom to which they are attached form a 3,4,5 or 6 membered heterocyclic ring); âOR (where R is hydrogen, C alkyl, C aryl, or C arylC alkyl, C alkenyl, C alkynyl, C aryl C alkenyl or C arylC alkynyl); or âSR (where R is hydrogen, C alkyl, C aryl, or C arylC alkyl).

US Patent:

6413944, Jul 2, 2002

Filed:

Dec 20, 1999

Appl. No.:

09/466779

Inventors:

Leroy B. Townsend - Ann Arbor MI
John C. Drach - Ann Arbor MI
Louis S. Kucera - Pfaff Town NC

Assignee:

Regents of the University of Michigan - Ann Arbor MI
Wake Forest University - Winston-Salem NC

International Classification:

A61K 3170

US Classification:

514 49, 514 51

Abstract:

Triciribine and analogs are effective antiviral agents.

US Patent:

6455506, Sep 24, 2002

Filed:

Jul 29, 1998

Appl. No.:

09/124484

Inventors:

Leroy B. Townsend - Ann Arbor MI
John C. Drach - Ann Arbor MI

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

A61K 3170

US Classification:

514 43, 536 289

Abstract:

The present invention pertains to D- and L-lyxofuranosyl benzimidazole compounds. In one embodiment, the present invention pertains to D- and L-lyxofuranosyl benzimidazole compounds selected from the group consisting of compounds having a formula selected from the following: wherein R , R , R , R , and R are independently the same or different and independently selected from the group consisting of: âH, âF, âCl, âBr, âI, âNO , âN(R ) , âOR , âSR , and âCF , wherein R is independently âH or an alkyl group having 1-6 carbon atoms and wherein R is independently âH or a hydrocarbyl group having 1-10 carbon atoms; and, R , R and R are independently the same or different and are H or a hydroxyl protecting group; anomeric and optical isomers thereof; and, pharmaceutically acceptable salts and prodrug derivatives thereof. The present invention also pertains to antiviral compositions using these compounds, methods of treating a viral infection using these compounds, and the use of these compounds in the preparation of a medicament for use in the treatment of a viral infection.

US Patent:

6455507, Sep 24, 2002

Filed:

Mar 17, 2000

Appl. No.:

09/424934

Inventors:

John Charles Drach - Ann Arbor MI
Leroy B. Townsend - Ann Arbor MI
Stanley Dawes Chamberlain - Research Triangle Park NC
Susan Mary Daluge - Research Triangle Park NC
David Norman Deaton - Research Triangle Park NC
Marc W. Andersen - Raleigh NC
George Andrew Freeman - Research Triangle Park NC

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

A61K 3170

US Classification:

514 43, 514 42, 514 45, 514 46, 514248, 514249, 514252, 514254, 536 41, 536 172, 536 173, 548469

Abstract:

Benzimidazole derivatives useful for treating or preventing viral infections such as those caused by herpes viruses or in the treatment of restenosis following surgical techniques. Methods of preparing these benzimidazole derivatives and pharmaceutical compositions containing them are described.

US Patent:

7419963, Sep 2, 2008

Filed:

Oct 6, 2004

Appl. No.:

10/959885

Inventors:

Leroy B. Townsend - Ann Arbor MI, US
John C. Drach - Ann Arbor MI, US

International Classification:

A61K 31/70
C07H 19/04

US Classification:

514 43, 536 2713

Abstract:

The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e. g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases.

US Patent:

7625871, Dec 1, 2009

Filed:

Feb 28, 2008

Appl. No.:

12/038919

Inventors:

Leroy B. Townsend - Ann Arbor MI, US
John C. Drach - Ann Arbor MI, US

Assignee:

The Regents of the University of Michigan - Ann Arbor MI

International Classification:

A61K 31/70
C07H 19/052

US Classification:

514 43, 536 2713

Abstract:

The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e. g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases.

US Patent:

7928080, Apr 19, 2011

Filed:

Jul 9, 2009

Appl. No.:

12/500311

Inventors:

Leroy B. Townsend - Ann Arbor MI, US
John C. Drach - Ann Arbor MI, US

Assignee:

The Regents of the University of Michigan - Ann Arbor MI

International Classification:

A61K 31/70
C07H 19/04

US Classification:

514 43, 536 2713

Abstract:

The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e. g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases.