Lesley M Pesnicak

US Patent:

20080279886, Nov 13, 2008

Filed:

Jun 22, 2005

Appl. No.:

11/630147

Inventors:

Jeffrey I. Cohen - Silver Spring MD, US
Lesley M. Pesnicak - Stafford VA, US

Assignee:

The Govt. of the U.S.A. as represented by the Secretary, Dept. of Health and Human Services - Rockville MD

International Classification:

A61K 39/12
A61K 39/245
A61K 39/255
A61P 37/04
A61P 31/12
A61K 39/25
A61K 39/205

US Classification:

4241991, 4242041, 4242301, 4242311, 4242241

Abstract:

Viruses having weakened ability to establish and/or maintain latency and their use as live vaccines are described. The vaccines have one or more alterations in genes that provide continued virus replication but that inhibit latency. The vaccine materials and methods for their construction are exemplified with the varicella zoster virus. Deletion of a significant portion from both copies of the varicella zoster gene ORF63 was shown to inhibit establishment of a latent infection from a live vaccine form of the virus. Insertion of an additional ORF62 gene which is partially truncated with the ORF63 deletion inhibited establishment of latency and allowed normal growth of the virus. Other desirable viral antigen encoding sequence(s) and/or cytokine genes advantageously may replace deleted genetic material to enhance a desired immunological response. Aspects of the discovery pertain to live vaccines of other viruses, and can provide a variety of vaccines having greater safety.

US Patent:

20130209506, Aug 15, 2013

Filed:

Nov 9, 2007

Appl. No.:

12/514011

Inventors:

Jeffrey I. Cohen - Silver Spring MD, US
Lesley Pesnicak - Stafford VA, US

Assignee:

THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the secretary of the department of - Rockville MD

International Classification:

A61K 39/25

US Classification:

4241991, 4352351, 435236

Abstract:

The disclosure provides recombinant herpes virus with diminished latency. In embodiments, the recombinant herpes virus comprises a latency gene or transcript linked to an altered or heterologous promoter. The disclosure also provides compositions and methods for inducing immunity in animals using the recombinant herpes viruses.

US Patent:

58107738, Sep 22, 1998

Filed:

Mar 25, 1997

Appl. No.:

8/823417

Inventors:

Lesley Pesnicak - Stafford VA

Assignee:

The United States of America as represented by the Department of Health
and Human Services - Washington DC

International Classification:

A61M 3700

US Classification:

604 83

Abstract:

An arrangement for mixing together two fluids includes a base and first, second, and third holding members each secured to the base. The first holding member is constructed and arranged to hold a first fluid holding device, such as a syringe, relative to a second fluid holding device, such as a syringe, and a connector. The second holding member is constructed and arranged to hold the second fluid holding device relative to the first fluid holding device and the connector. The third holding member is constructed and arranged to hold the connector relative to the first fluid holding device and second fluid holding device. The third holding member is positioned on the base in axial alignment with both the first holding member and the second holding member. A method for mixing two fluids includes connecting first and second syringes with a three-way stopcock. The connected syringes are positioned on a base containing three holding members.

US Patent:

20220193227, Jun 23, 2022

Filed:

Mar 11, 2022

Appl. No.:

17/692540

Inventors:

- Bethesda MD, US
Lesley Pesnicak - Stafford VA, US

Assignee:

The U.S.A., as represented by the Secretary, Department of Health and Human Services - Bethesda MD

International Classification:

A61K 39/25
A61K 39/12
A61K 39/245
C07K 14/005
C12N 7/00
C12N 15/86

Abstract:

The disclosure provides recombinant herpes virus with diminished latency. In embodiments, the recombinant herpes virus comprises a latency gene or transcript linked to an altered or heterologous promoter. The disclosure also provides compositions and methods for inducing immunity in animals using the recombinant herpes viruses.

US Patent:

20190167784, Jun 6, 2019

Filed:

Nov 19, 2018

Appl. No.:

16/195247

Inventors:

- Bethesda MD, US
Lesley Pesnicak - Stafford VA, US

Assignee:

The U.S.A., as represented by the Secretary, Department of Health and Human Services - Bethesda MD

International Classification:

A61K 39/25
A61K 39/12
C07K 14/005
C12N 7/00
C12N 15/86
A61K 39/245

Abstract:

The disclosure provides recombinant herpes virus with diminished latency. In embodiments, the recombinant herpes virus comprises a latency gene or transcript linked to an altered or heterologous promoter. The disclosure also provides compositions and methods for inducing immunity in animals using the recombinant herpes viruses.