Leslie A Robinson

US Patent:

6410580, Jun 25, 2002

Filed:

Aug 2, 2000

Appl. No.:

09/601462

Inventors:

Paivi Jaana Kukkola - Whitehouse Station NJ
Leslie Ann Robinson - Del Mar CA
Junichi Sakaki - Kawasaki, JP
Motowo Nakajima - Ashiya, JP

Assignee:

Novartis AG - Basel

International Classification:

C07D27506

US Classification:

514373, 514444, 514471, 549 59, 549476, 548210

Abstract:

Compounds of formula (I) wherein W is âOH or âNHOH; X is an optionally substituted heterocycle, NR SO R , heterocyclylalkythio, CONR R or NR COR ; Y, Z, R -R and n are as defined in the application. Compounds (I) are inhibitors of matrix-degrading metalloproteinases and are use for the treatment of related conditions.

US Patent:

6492394, Dec 10, 2002

Filed:

Dec 22, 1999

Appl. No.:

09/469660

Inventors:

Chris Allen Broka - Foster City CA
Jeffrey Allen Campbell - Fremont CA
Jian Jeffrey Chen - Santa Clara CA
Sharon Marie Dankwardt - Foster City CA
Nancy Delaet - San Diego CA
Leslie Ann Robinson - Los Altos CA
Keith Adrian Murray Walker - Los Altos CA

Assignee:

Syntex (U.S.A.) LLC - Palo Alto CA

International Classification:

A61K 31445

US Classification:

514321, 5142275, 5142278, 5142282, 5142312, 5142338, 5142345, 5142352, 5142355, 514255, 514311, 514314, 514318, 514322, 514323, 514326, 514337, 514338, 514339, 514394, 514412, 514419, 514422, 514438, 514443, 514464, 544 584, 544124, 544128, 544139, 544143, 544153, 544159, 544363, 544370, 544373, 544377, 544386, 546193, 546197, 546199, 546201, 546229, 546264, 5462734, 5462774, 548495, 548517, 548518, 548561, 549 59, 549 75, 549 76, 549 77, 549440, 549448, 549452

Abstract:

A compound of the Formula (I): wherein Z, R , R, and Ar are as defined in the specification. This invention also relates to sulfonamide compounds of the Formula (I) that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use, and methods for preparing the compounds.

US Patent:

6787559, Sep 7, 2004

Filed:

Oct 9, 2002

Appl. No.:

10/267727

Inventors:

Chris Allen Broka - Foster City CA
Jeffrey Allen Campbell - Fremont CA
Jian Jeffrey Chen - Santa Clara CA
Sharon Marie Dankwardt - Foster City CA
Nancy Delaet - San Diego CA
Leslie Ann Robinson - Los Altos CA
Keith Adrian Murray Walker - Los Altos CA

Assignee:

Syntex (U.S.A.) LLC. - Palo Alto CA

International Classification:

A61K 31445

US Classification:

514321, 5142275, 5142278, 5142282, 5142312, 5142338, 5142345, 514318, 514338, 514394, 514412, 514419, 514422, 514443, 514464, 546193, 546197, 546201, 546229, 5462734, 5462774, 549440, 549448, 549452

Abstract:

This invention relates to certain sulfonamide derivatives that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.

US Patent:

6844366, Jan 18, 2005

Filed:

Oct 9, 2002

Appl. No.:

10/267292

Inventors:

Chris Allen Broka - Foster City CA, US
Jeffrey Allen Campbell - Fremont CA, US
Jian Jeffrey Chen - Santa Clara CA, US
Sharon Marie Dankwardt - Foster City CA, US
Nancy Delaet - San Diego CA, US
Leslie Ann Robinson - Los Altos CA, US
Keith Adrian Murray Walker - Los Altos CA, US

Assignee:

Syntex (U.S.A.) LLC - Palo Alto CA

International Classification:

A61K 31165
C07C25904

US Classification:

514575, 5142222, 5142378, 514255, 514331, 514357, 514438, 544 59, 544106, 544398, 546229, 546266, 549 74, 549623

Abstract:

This invention relates to certain sulfonamide derivatives that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.

US Patent:

20040235896, Nov 25, 2004

Filed:

May 13, 2004

Appl. No.:

10/471245

Inventors:

Roger Fujimoto - Morristown NJ, US
Leslie McQuire - Warren NJ, US
Lauren Monovich - Summit NJ, US
Philippe Nantermet - Lansdale PA, US
David Parker - Livingston NJ, US
Leslie Robinson - Del Mar CA, US
Jerry Skiles - New Providence NJ, US
Ruben Tommasi - Whitehouse Station NJ, US

International Classification:

A61K031/445
C07D211/32
A61K031/55
A61K031/40

US Classification:

514/317000, 546/232000, 546/233000, 514/408000, 514/217120

Abstract:

Compounds of the formula (I) wherein R represents OH or NHOH; Rrepresents hydrogen, optionally substituted lower alkyl, aryl-lower alkyl, cycloalkyl-lower alkyl, or acyl derived from a carboxylic acid, from a carbonic acid, from a carbamic acid of from a sulfonic acid; Rrepresents biarylsulfonyl or aryloxyarylsufonyl; Rrepresents hydrogen, optionally substituted lower alkyl, aryl-lower alkyl, cycloalkyl-lower alkyl or acyl derived from a carboxylic acid, from a carbonic acid or form a carbamic acid; Rand Rrepresent independently hydrogen, lower alkyl, lower alkoxycarbonyl, aryl-lower alkyl or cycloalkyl-lower alkyl; m is zero, 1, 2 or 3; pharmaceutically acceptable prodrug derivatives thereof; pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising said compounds; and their use for inhibiting matrix degrading metalloproteinases and preventing or treating matrix metalloproteinase dependent conditions in mammals.

US Patent:

20070060569, Mar 15, 2007

Filed:

Nov 2, 2006

Appl. No.:

11/591861

Inventors:

Roger Fujimoto - Morristown NJ, US
Leslie McQuire - Warren NJ, US
Lauren Monovich - Summit NJ, US
Philippe Nantermet - Lansdale PA, US
David Parker - Livingston NJ, US
Leslie Robinson - Del Mar CA, US
Jerry Skiles - North borbugh MA, US
Ruben Tommasi - Whitehouse Station NJ, US

International Classification:

A61K 31/55
A61K 31/501
A61K 31/454
A61K 31/4545
C07D 409/02
C07D 417/02
C07D 405/02
C07D 403/02

US Classification:

514217040, 514217120, 514217050, 514217080, 514252030, 514326000, 514318000, 540597000, 540598000, 540596000, 540609000, 544238000, 546193000, 546209000, 546229000

Abstract:

Compound of the formula wherein R represents OH or NHOH; Rrepresents hydrogen, optically substituted lower alkyl, aryl-lower alkyl, cycloalkyl-lower alkyl, or acyl derived from a carboxylic acid, from a carbonic acid, from a carbamic acid or from a sulfonic acid; Rrepresents biarylsulfonyl or aryloxyrylsulfonyl; Rrepresents hydrogen, optionally substituted lower alkyl, aryl-lower alkyl, cycloalkyl-lower alkyl or acyl derived from a carboxylic acid, from a carbonic acid or from a carbamic acid; Rand Rrepresent independently hydrogen, lower alkyl, lower alkoxycarbonyl, aryl-lower alkyl or cycloalkyl-lower alkyl; m is zero, 1, 2 or 3; pharmaceutically acceptable prodrug derivatives thereof; pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising said compounds; and their use for inhibiting matrix degrading metalloproteinases and preventing or treating matrix metalloproteinase dependent conditions in mammals.

US Patent:

62779877, Aug 21, 2001

Filed:

Feb 3, 1999

Appl. No.:

9/243854

Inventors:

Paivi Jaana Kukkola - Whitehouse Station NJ
Leslie Anne Robinson - Del Mar CA
Motowo Nakajima - Ashiya, JP
Junichi Sakaki - Takarazuka, JP

Assignee:

Novartis AG - Basel

International Classification:

C07D23972
C07D20948
C07D27504
A61K 31415
A61K 3140

US Classification:

544285

Abstract:

Compounds of formula ##STR1## wherein W is --OH or --NHOH; X is a heterocycle with the proviso that when X is a nitrogen containing heterocycle, the heterocycle is attached to the (CH. sub. 2). sub. m moiety by a ring nitrogen, --CONR. sub. 2 R. sub. 3, --NR. sub. 1 COR. sub. 2, --NR. sub. 1 SO. sub. 2 R. sub. 2, --NR. sub. 1 CONR. sub. 2 R. sub. 3, --NR. sub. 1 COOR. sub. 4, heteroarylthio, alkylthio, arylalkylthio, heteroarylalkylthio, heterocycloalkylalkylthio, heterocycloalkylthio or arylthio; Y is carbon, nitrogen, oxygen or sulfur, provided that when Y is carbon, n is 2; Z is alkyl, aryl, alkoxy, aryloxy, aralkoxyaryl, aralkoxyheteroaryl, heteroaryl, heterocycloalkyl, heteroaryloxy, --CONR. sub. 2 R. sub. 3, --NR. sub. 1 COR. sub. 2, --NR. sub. 1 CONR. sub. 2 R. sub. 3, --OCONR. sub. 2 R. sub. 3, --NR. sub. 1 COOR. sub. 4, or --SO. sub. 2 R. sub.