Lester C Hall

US Patent:

6963770, Nov 8, 2005

Filed:

Apr 24, 2003

Appl. No.:

10/422120

Inventors:

Charles W. Scarantino - Raleigh NC, US
H. Troy Nagle - Durham NC, US
Lester C. Hall - Hollywood FL, US
Jeffrey Mueller - Winston Salem NC, US

Assignee:

North Carolina State University - Raleigh NC
Sicel Techonologies, Inc. - Morrisville NC

International Classification:

A61B006/00
A61B005/07

US Classification:

600436, 128903, 600302

Abstract:

Methods of monitoring and evaluating the status of a tumor undergoing treatment includes monitoring in vivo at least one physiological parameter associated with a tumor in a subject undergoing treatment, transmitting data from an in situ located sensor to a receiver external of the subject, analyzing the transmitted data, repeating the monitoring and transmitting steps at sequential points in time and evaluating a treatment strategy. The method provides dynamic tracking of the monitored parameters over time. The method can also include identifying in a substantially real time manner when conditions are favorable for treatment and when conditions are unfavorable for treatment and can verify or quantify how much of a known drug dose or radiation dose was actually received at the tumor. The method can include remote transmission from a non-clinical site to allow oversight of the tumor's condition even during non-active treatment periods (in between active treatments). The disclosure also includes monitoring systems with in situ in vivo biocompatible sensors and telemetry based operations and related computer program products.

US Patent:

6963771, Nov 8, 2005

Filed:

Sep 4, 2003

Appl. No.:

10/655317

Inventors:

Charles W. Scarantino - Raleigh NC, US
H. Troy Nagle - Durham NC, US
Lester C. Hall - Hollywood FL, US
Jeffrey Mueller - Winston Salem NC, US

Assignee:

North Carolina State University - Raleigh NC
Sicel Technologies, Inc. - Morrisville NC

International Classification:

A61B006/00
A61B005/07

US Classification:

600436, 128903, 600302

Abstract:

Methods and systems for evaluating external beam radiation therapy delivered to a subject include: (a) placing at least one wireless implantable sensor in a first subject at a target location; (b) administering a first dose of radiation therapy into the first subject; (c) obtaining radiation data from the at least one wireless implantable sensor; and (d) calculating a radiation dose amount received by the first subject at the target location based on the radiation data obtained from the at least one wireless sensor during and/or after exposure to the first administered dose of radiation to determine and/or verify a dose amount of radiation delivered to the target location.

US Patent:

7010340, Mar 7, 2006

Filed:

Feb 18, 2002

Appl. No.:

10/078310

Inventors:

Charles W. Scarantino - Raleigh NC, US
H. Troy Nagle - Durham NC, US
Lester C. Hall - Hollywood FL, US
Jeffrey Mueller - Winston Salem NC, US
Bahram Ghaffarzadeh Kermani - San Diego CA, US

Assignee:

North Carolina State University - Raleigh NC
Sicel Technologies, Inc - Morrisville NC

International Classification:

A61B 6/00
A61B 5/07

US Classification:

600436, 128903, 600302, 600549

Abstract:

Methods of monitoring and evaluating the status of a tumor undergoing treatment includes monitoring in vivo at least one physiological parameter associated with a tumor in a subject undergoing treatment, transmitting data from an in situ located sensor to a receiver external of the subject, analyzing the transmitted data, repeating the monitoring and transmitting steps at sequential points in time and evaluating a treatment strategy. The method provides dynamic tracking of the monitored parameters over time. The method can also include identifying in a substantially real time manner when conditions are favorable for treatment and when conditions are unfavorable for treatment and can verify or quantify how much of a known drug dose or radiation dose was actually received at the tumor. The method can include remote transmission from a non-clinical site to allow oversight of the tumor's condition even during non-active treatment periods (in between active treatments). The disclosure also includes monitoring systems with in situ in vivo biocompatible sensors and telemetry based operations and related computer program products.

US Patent:

7756568, Jul 13, 2010

Filed:

Jun 9, 2005

Appl. No.:

11/148608

Inventors:

Charles W. Scarantino - Raleigh NC, US
H. Troy Nagle - Durham NC, US
Lester C. Hall - Hollywood FL, US
Jeffrey Mueller - Winston Salem NC, US
Bahram Ghaffarzadeh Kermani - San Diego CA, US

Assignee:

North Carolina State University - Raleigh NC
Sicel Technologies, Inc. - Morrisville NC

International Classification:

A61B 6/00
A61B 5/07

US Classification:

600436, 128903, 600302, 600549

Abstract:

Biocompatible sensors configured for implantation include a first body in communication with a plurality of remote sensor bodies to detect physiological parameters in vivo.

US Patent:

7769431, Aug 3, 2010

Filed:

May 2, 2006

Appl. No.:

11/381223

Inventors:

Charles W. Scarantino - Raleigh NC, US
H. Troy Nagle - Durham NC, US
Lester C. Hall - Hollywood FL, US
Jeffrey Mueller - Winston-Salem NC, US
Bahram G. Kermani - Los Altos CA, US

Assignee:

North Carolina State University - Raleigh NC
Sicel Technologies, Inc. - Morrisville NC

International Classification:

A61B 6/00
A61B 5/07

US Classification:

600436, 128903, 600302

Abstract:

Methods and systems for evaluating external beam radiation therapy delivered to a subject include: (a) placing at least one wireless implantable sensor in a first subject at a target location; (b) administering a first dose of radiation therapy into tile first subject; (c) obtaining radiation data from the at least one wireless implantable sensor; and (d) calculating a radiation dose amount received by the first subject at the target location based on the radiation data obtained from the at least one wireless sensor during and/or after exposure to the first administered dose of radiation to determine and/or verify a dose amount of radiation delivered to the target location.

US Patent:

7778692, Aug 17, 2010

Filed:

May 2, 2006

Appl. No.:

11/381233

Inventors:

Charles W. Scarantino - Raleigh NC, US
H. Troy Nagle - Durham NC, US
Lester C. Hall - Hollywood FL, US
Jeffrey Mueller - Winston Salem NC, US
Bahram G. Kermani - Los Altos CA, US

Assignee:

North Carolina State University - Raleigh NC
Sicel Technologies, Inc. - Morrisville NC

International Classification:

A61B 6/00
A61N 5/10

US Classification:

600436, 128903, 378 65

Abstract:

Methods and systems for evaluating external beam radiation therapy delivered to a subject include: (a) placing at least one wireless implantable sensor in a first subject at a target location; (b) administering a first dose of radiation therapy into the first subject; (c) obtaining radiation data from the at least one wireless implantable sensor; and (d) calculating a radiation dose amount received by the first subject at the target location based on the radiation data obtained from the at least one wireless sensor during and/or after exposure to the first administered dose of radiation to determine and/or verify a dose amount of radiation delivered to the target location.

US Patent:

7787937, Aug 31, 2010

Filed:

Jul 20, 2005

Appl. No.:

11/185284

Inventors:

Charles W. Scarantino - Raleigh NC, US
H. Troy Nagle - Durham NC, US
Lester C. Hall - Hollywood FL, US
Jeffrey Mueller - Winston Salem NC, US
Bahram G. Kermani - Los Altos CA, US

Assignee:

North Carolina State University - Raleigh NC
Sicel Technologies, Inc. - Morrisville NC

International Classification:

A61B 6/00
A61B 5/07
A61K 51/00

US Classification:

600436, 128903, 424 92

Abstract:

Methods and systems for evaluating external beam radiation therapy delivered to a subject include: (a) placing at least one wireless implantable sensor in a first subject at a target location; (b) administering a first dose of radiation therapy into the first subject; (c) obtaining radiation data from the at least one wireless implantable sensor; and (d) calculating a radiation dose amount received by the first subject at the target location based on the radiation data obtained from the at least one wireless sensor during and/or after exposure to the first administered dose of radiation to determine and/or verify a dose amount of radiation delivered to the target location.

US Patent:

8380290, Feb 19, 2013

Filed:

Jun 25, 2010

Appl. No.:

12/823521

Inventors:

Charles W. Scarantino - Raleigh NC, US
H. Troy Nagle - Durham NC, US
Lester C. Hall - Hollywood FL, US
Jeffrey Mueller - Winston-Salem NC, US
Bahram Ghaffarzadeh Kermani - Los Altos CA, US

Assignee:

North Carolina State University - Raleigh NC
SNC Holdings Corp. - Morrisville NC

International Classification:

A61B 6/00
A61B 5/07

US Classification:

600436, 600549, 600302, 128903

Abstract:

Biocompatible sensors configured for implantation include a first body in communication with a plurality of remote sensor bodies to detect physiological parameters in vivo.