Li Jing Chen

US Patent:

6455550, Sep 24, 2002

Filed:

Aug 21, 1998

Appl. No.:

09/138353

Inventors:

Li Chen - Westfield NJ
Robert William Guthrie - Saddle Brook NJ
Jefferson Wright Tilley - North Caldwell NJ
Kenneth Gregory Hull - Cambridge MA

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

A61K 314166

US Classification:

514341, 514386, 5462744, 5483225, 5483255

Abstract:

Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.

US Patent:

6600015, Jul 29, 2003

Filed:

Mar 19, 2001

Appl. No.:

09/811964

Inventors:

Li Chen - Westfield NJ
Adrian Wai-Hing Cheung - Glen Rock NJ
Waleed Danho - Wayne NJ
Joseph Swistok - Nutley NJ
Keith Alan Yagaloff - HoHokus NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07K 508

US Classification:

530331, 530330, 514 18

Abstract:

Peptides that selectively stimulate melanocortin-4 (MC-4) receptor activity are disclosed. In one embodiment, the peptides are of formula I:.

US Patent:

6756374, Jun 29, 2004

Filed:

Jan 9, 2002

Appl. No.:

10/042619

Inventors:

Li Chen - Westfield NJ
Qingjie Ding - Bridgewater NJ
Paul Gillespie - Westfield NJ
Kyungjin Kim - Livingston NJ
Allen John Lovey - North Caldwell NJ
Warren William McComas - Denville NJ
Agostino Perrotta - Bloomfield NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

A61K 31496

US Classification:

5142358, 5142531, 51425402, 544121, 544304, 544367

Abstract:

Disclosed are novel diaminothiazoles of formula wherein R , R , R , R and R are as herein disclosed. These compounds and their pharmaceutically acceptable salts and esters are selective inhibitors of Cdk4. As such, these compounds and their pharmaceutically acceptable salts and esters are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing the compounds of formula I and their pharmaceutically acceptable salts and esters, as well as intermediates useful in the preparation of the compounds of formula I.

US Patent:

6806365, Oct 19, 2004

Filed:

Apr 5, 2002

Appl. No.:

10/117616

Inventors:

Li Chen - Westfield NJ
Robert William Guthrie - Saddle Brook NJ
Jefferson Wright Tilley - North Caldwell NJ
Kenneth Gregory Hull - Cambridge MA

Assignee:

Hoffmann-La Rocher Inc. - Nutley NJ

International Classification:

C07C22902

US Classification:

544169, 546323, 548214, 548253, 5483741, 548536, 549436, 552 10, 558406, 558415, 560 30, 562426, 562429, 562430, 562435, 562441, 562448, 562449

Abstract:

Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.

US Patent:

7045591, May 16, 2006

Filed:

Aug 27, 2001

Appl. No.:

09/939966

Inventors:

Li Chen - Westfield NJ, US
Adrian Wai-Hing Cheung - Glen Rock NJ, US
Waleed Danho - Wayne NJ, US
Joseph Swistok - Nutley NJ, US
Yao Wang - Edison NJ, US
Keith Alan Yagaloff - Broad Brook CT, US

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07K 7/50

US Classification:

530317, 514 11, 514 17, 530318, 530328, 530330

Abstract:

Peptides cyclized via disulfide or lactam bridges are disclosed. The peptides exhibit melanocortin-4 receptor agonist activity and are useful for treating obesity.

US Patent:

8126762, Feb 28, 2012

Filed:

Apr 2, 2008

Appl. No.:

12/061029

Inventors:

Bala Ramachandran - Harrison NY, US
Li Chen - Palo Alto CA, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06F 17/30

US Classification:

705 728

Abstract:

A stabilization methodology and system component in Business Activity Monitoring and Management systems. This enables firms to use Business Activity Management (BAM) systems to manage business activity by only responding to monitored data when the overall business performance can be improved. This enables firms to identify appropriate tradeoffs between potentially conflicting objectives while meeting business objectives. Information from BAM systems are analyzed based on models of the business process and different information filter criteria are assessed for their impact on business performance indicators. Based on this, a filter criterion is chosen which is executed by an information filter. The outputs from the information filter are used as the basis for deciding the inputs for business process execution.

US Patent:

20030229200, Dec 11, 2003

Filed:

May 9, 2003

Appl. No.:

10/435466

Inventors:

Li Chen - Westfield NJ, US
Adrian Cheung - Glen Rock NJ, US
Waleed Danho - Wayne NJ, US
Joseph Swistok - Nutley NJ, US
Keith Yagaloff - Hohokus NJ, US

International Classification:

C07K007/06
A61K038/08

US Classification:

530/330000, 514/017000

Abstract:

Peptides of formulae I, II and III that selectively activate melanocortin-4 (MC-4) receptor activity.

US Patent:

20040210051, Oct 21, 2004

Filed:

Apr 21, 2004

Appl. No.:

10/828771

Inventors:

Li Chen - Westfield NJ, US
Robert Guthrie - Saddle Brook NJ, US
Jefferson Tilley - North Caldwell NJ, US
Kenneth Hull - Cambridge MA, US

International Classification:

C07D279/12
C07D277/04
C07D263/34
C07D211/32

US Classification:

544/059000, 544/162000, 544/386000, 546/225000, 548/200000, 548/236000, 548/333500, 548/530000

Abstract:

Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.