Li C Liu

US Patent:

6337408, Jan 8, 2002

Filed:

Mar 22, 2000

Appl. No.:

09/533368

Inventors:

Andrew Allen - Exton PA
Ann Marie Diederich - Downingtown PA
Li Liu - Collegeville PA
Wilford Mendelson - King of Prussia PA
Kevin Webb - Phoenixville PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07D30300

US Classification:

549332, 560 59, 558409, 564163

Abstract:

This invention relates to a method of preparing a compound of the following type by treating a compound of formula (II) with lithium bromide, magnesium bromide and the like.

US Patent:

6569638, May 27, 2003

Filed:

Mar 3, 2000

Appl. No.:

09/517734

Inventors:

I. Bernard Weinstein - Englewood NJ
W. Joseph Thompson - Doylestown PA
Jae-Won Soh - Cliffside Park NJ
Li Liu - Ambler PA
Han Li - Yardley PA

Assignee:

Cell Pathways, Inc - Horsham PA

International Classification:

C12Q 148

US Classification:

435 15, 435 692, 435184

Abstract:

This invention provides a method to identify compounds potentially useful for the treatment and prevention of neoplasia in mammals. The phosphodiesterase inhibitory activity of a compound is determined along with its ability to elevate JNK kinase activity. Growth inhibitory and apoptosis inducing effects on cultured tumor cells are also determined. Compounds that exhibit phosphodiesterase inhibition, an ability to elevate JNK kinase activity, growth inhibition and apoptosis induction are desirable for the treatment of neoplasia.

US Patent:

7049324, May 23, 2006

Filed:

Nov 15, 2000

Appl. No.:

10/130322

Inventors:

Ashis Kumar Saha - Harleysville PA, US
David William End - Ambler PA, US
Bart Lieven Daniel De Corte - Southampton PA, US
Henry Joseph Breslin - Lansdale PA, US
Li Liu - Doylestown PA, US

International Classification:

A61K 31/47
C07D 215/38
C07D 249/08

US Classification:

514311, 5482622, 5482676, 546169, 514383

Abstract:

p-00010000.

US Patent:

7154670, Dec 26, 2006

Filed:

Mar 10, 2004

Appl. No.:

10/796930

Inventors:

Hongbin Zhang - Marlboro NJ, US
Li Liu - Carneys Point NJ, US
R. Brian Jander - Freehold NJ, US
Alexei N. Pilipetskii - Colts Neck NJ, US

Assignee:

Tyco Telecommunications (US) Inc. - Morristown NJ

International Classification:

G02B 27/28

US Classification:

359501, 359497, 385 11

Abstract:

Methods and apparatus of performing polarization control for optical transmissions. The methods and apparatus enable polarization control devices to achieve a desired output state of polarization regardless of the input state of polarization. The desired state of polarization can be achieved by rotating waveplates in a polarization controller in a sequential fashion. Each waveplate may be continually adjusted or dithered so long as the feedback signal satisfies a feedback condition. Once the feedback signal exceeds the feedback condition, the next waveplate in the polarization controller is adjusted. This enables the methods and apparatus to rapidly adjust the state of polarization away from dead spots and minimize loss control problems.

US Patent:

7511061, Mar 31, 2009

Filed:

Jun 2, 2005

Appl. No.:

11/143814

Inventors:

Ashis Kumar Saha - Harleysville PA, US
David William End - Ambler PA, US
Bart Lieven Daniel De Corte - Southampton PA, US
Henry Joseph Breslin - Lansdale PA, US
Li Liu - Doylestown PA, US

Assignee:

Janssen Pharmaceutica N.V. - Beerse

International Classification:

A61K 31/4196
A61K 31/47
C07D 215/00
C07D 249/06

US Classification:

514311, 546112, 546152, 546169, 5482622, 5482676, 514383

Abstract:

A prodrug, N-oxide, addition salt, quaternary amine or stereochemically isomeric form thereof, wherein Land Lare R—Y— wherein each (R—Y)— substituent is defined independently of the other; Y is Calkanediyl, Calkenediyl, Calkynediyl, C(═O), or a direct bond; Ris hydrogen, cyano, aryl or a substituted or unsubstituted Cheterocycle; =Z-Z=Z- represents a radical of formula ═N—N═CH— (a-1), ═N—CH═N— (a-2), ═CH—N═N— (a-3); X is SO, (CH)wherein n is 1 to 4, C(═O), C(═S), or a direct bond; Ris aryl, Ccycloalkyl, Ccycloalkyl substituted with one or more substituents independently selected from hydroxy, aryl, aryloxy, a substituted or unsubstituted Cheterocycle, Ccycloalkyl, hydroxycarbonyl, Calkyloxycarbonyl, hydroxyCalkyl, hydroxyCalkyloxy, hydroxyCalkylthio and arylCalkylthio, Calkyl or Calkyl substituted with one or more substituents independently selected from hydroxy, aryl, aryloxy, a substituted or unsubstituted Cheterocycle, Ccycloalkyl, hydroxycarbonyl, Calkyloxycarbonyl, hydroxyCalkyl, hydroxyCalkyloxy, hydroxyCalkylthio and arylCalkylthio; Ris aryl, —NRR, a substituted or unsubstituted Cheterocycle, or Calkenediyl substituted with a substituted or unsubstituted Cheterocycle or aryl; Ris hydrogen, aryl, Ccycloalkyl, Calkyl or Calkyl substituted with Ccycloalkyl, hydroxycarbonyl, Calkyloxycarbonyl or aryl; Rand Rare each independently selected from hydrogen, a substituted or unsubstituted Cheterocycle, aryl, Calkyl and Calkyl substituted with one or more substituents selected from hydroxy, aryl, aryloxy or a substituted or unsubstituted Cheterocycle.

US Patent:

7582650, Sep 1, 2009

Filed:

Jun 15, 2006

Appl. No.:

11/424311

Inventors:

Bart DeCorte - Southampton PA, US
Li Liu - Doylestown PA, US
Mark McDonnell - Lansdale PA, US
Jim McNally - Souderton PA, US

Assignee:

Janssen Pharmaceutica N.V. - Beerse

International Classification:

C07D 221/22
A61K 31/46

US Classification:

514299, 546112

Abstract:

The invention is directed to compounds of Formula (I) useful as delta and mu opioid receptor modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.

US Patent:

7589104, Sep 15, 2009

Filed:

Dec 21, 2005

Appl. No.:

11/313704

Inventors:

John R. Carson - Norristown PA, US
Scott L. Dax - Landenberg PA, US
Bart DeCorte - Southhampton PA, US
Li Liu - Doylestown PA, US
Mark McDonnell - Lansdale PA, US
James J. McNally - Souderton PA, US

Assignee:

Janssen Pharmaceutica NV - Beerse

International Classification:

C07D 405/04
A61K 31/46

US Classification:

514304, 546126

Abstract:

Disclosed are compounds, compositions and methods for treating various diseases and conditions, including pain. Such compounds are represented by Formula I as follows:.

US Patent:

7592356, Sep 22, 2009

Filed:

Oct 29, 2007

Appl. No.:

11/926858

Inventors:

Ashis Kumar Saha - Harleysville PA, US
David William End - Ambler PA, US
Bart Lieven Daniel De Corte - Southampton PA, US
Henry Joseph Breslin - Lansdale PA, US
Li Liu - Doylestown PA, US

Assignee:

Janssen Pharmaceutica N.V. - Beerse

International Classification:

A61K 31/47
C07D 249/08

US Classification:

514311, 5482622, 5482672, 546152, 546174, 514383

Abstract:

p-00010000.