Interventional Pain Physicians 5304 Main St, New Port Richey, FL 34652 (727)5978430 (phone), (727)5978431 (fax)
Education:
Medical School Shandong Med Univ, Jinan, Shandong, China (242 46 Prior 1 1 71) Graduated: 1988
Languages:
English Spanish
Description:
Dr. Ma graduated from the Shandong Med Univ, Jinan, Shandong, China (242 46 Prior 1 1 71) in 1988. She works in New Port Richey, FL and specializes in Anesthesiology and Pain Management.
Medical School Xuzhou Med Coll, Xuzhou City, Jiangsu, China Graduated: 1982
Languages:
English
Description:
Dr. Ma graduated from the Xuzhou Med Coll, Xuzhou City, Jiangsu, China in 1982. He works in Brunswick, GA and specializes in Anatomic Pathology & Clinical Pathology.
- Ann Arbor MI, US Wei-Jie Zhou - Ann Arbor MI, US Li Ma - Saline MI, US
Assignee:
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
A61K 38/17
Abstract:
The present invention relates to compositions and methods for inducing intestinal stem cell homeogenesis and/or regeneration within intestinal tissue expressing Robo1 through administration of a Rspo1 agent and a Slit2 agent. Administration of such agents results in, for example, binding of the Rspo1 agent and Slit2 agent with Robo1, resulting in, for example, binding of the CC3 motif of Robo1 with LRP6, resulting in phosphorylation of LRP6, and ultimately, induction of intestinal stem cell homeogenesis and/or regeneration. In certain embodiments, such administration of a Rspo1 agent and a Slit2 agent is used to protect and/or prevent intestinal tissue damage resulting from exposure to an intestinal tissue damaging event (e.g., radiation). The agents and related compositions additionally find use in diagnostic and research settings.