Interventional Pain Physicians 5304 Main St, New Port Richey, FL 34652 (727)5978430 (phone), (727)5978431 (fax)
Education:
Medical School Shandong Med Univ, Jinan, Shandong, China (242 46 Prior 1 1 71) Graduated: 1988
Languages:
English Spanish
Description:
Dr. Ma graduated from the Shandong Med Univ, Jinan, Shandong, China (242 46 Prior 1 1 71) in 1988. She works in New Port Richey, FL and specializes in Anesthesiology and Pain Management.
Medical School Xuzhou Med Coll, Xuzhou City, Jiangsu, China Graduated: 1982
Languages:
English
Description:
Dr. Ma graduated from the Xuzhou Med Coll, Xuzhou City, Jiangsu, China in 1982. He works in Brunswick, GA and specializes in Anatomic Pathology & Clinical Pathology.
Discovery of a new Bax isoform, BaxΔ2, in cancer cell lines and primary tumors is described. The BaxΔ2 isoform resulted from combination of Bax microsatellite mutation and alternative splicing Bax exon 2. It is also discovered that BaxΔ2 renders cancer cells sensitive to certain chemotherapeutic drugs that target caspase 8. Also provided are methods for treating colorectal cancer by administering to a colorectal cancer patient a chemotherapeutic agent that is capable of activating caspase 8, wherein the patient contains a cancer cell that expresses a BaxΔ2 protein (SEQ ID NO. 2).
Treating Bax(Delta)2-Positive Cancer With Chemotherapies Targeting Caspase 8
Jialing Xiang - Chicago IL, US Li Ma - Chicago IL, US
Assignee:
Mumetel, LLC - Saint Charles IL
International Classification:
A61K 31/513 A61K 45/06 A61K 31/17
US Classification:
514274, 514588
Abstract:
Discovery of a new Bax isoform, BaxΔ2, in cancer cell lines and primary tumors is described. The BaxΔ2 isoform resulted from combination of Bax microsatellite mutation and alternative splicing Bax exon 2. It is also discovered that BaxΔ2 renders cancer cells sensitive to certain chemotherapeutic drugs that target caspase 8. Also provided are methods for treating colorectal cancer by administering to a colorectal cancer patient a chemotherapeutic agent that is capable of activating caspase 8, wherein the patient contains a cancer cell that expresses a BaxΔ2 protein (SEQ ID NO. 2).