Interventional Pain Physicians 5304 Main St, New Port Richey, FL 34652 (727)5978430 (phone), (727)5978431 (fax)
Education:
Medical School Shandong Med Univ, Jinan, Shandong, China (242 46 Prior 1 1 71) Graduated: 1988
Languages:
English Spanish
Description:
Dr. Ma graduated from the Shandong Med Univ, Jinan, Shandong, China (242 46 Prior 1 1 71) in 1988. She works in New Port Richey, FL and specializes in Anesthesiology and Pain Management.
Medical School Xuzhou Med Coll, Xuzhou City, Jiangsu, China Graduated: 1982
Languages:
English
Description:
Dr. Ma graduated from the Xuzhou Med Coll, Xuzhou City, Jiangsu, China in 1982. He works in Brunswick, GA and specializes in Anatomic Pathology & Clinical Pathology.
Discovery of a new Bax isoform, BaxΔ2, in cancer cell lines and primary tumors is described. The BaxΔ2 isoform resulted from combination of Bax microsatellite mutation and alternative splicing Bax exon 2. It is also discovered that BaxΔ2 renders cancer cells sensitive to certain chemotherapeutic drugs that target caspase 8. Also provided are methods for treating colorectal cancer by administering to a colorectal cancer patient a chemotherapeutic agent that is capable of activating caspase 8, wherein the patient contains a cancer cell that expresses a BaxΔ2 protein (SEQ ID NO. 2).
Treating Bax(Delta)2-Positive Cancer With Chemotherapies Targeting Caspase 8
Jialing Xiang - Chicago IL, US Li Ma - Chicago IL, US
Assignee:
Mumetel, LLC - Saint Charles IL
International Classification:
A61K 31/513 A61K 45/06 A61K 31/17
US Classification:
514274, 514588
Abstract:
Discovery of a new Bax isoform, BaxΔ2, in cancer cell lines and primary tumors is described. The BaxΔ2 isoform resulted from combination of Bax microsatellite mutation and alternative splicing Bax exon 2. It is also discovered that BaxΔ2 renders cancer cells sensitive to certain chemotherapeutic drugs that target caspase 8. Also provided are methods for treating colorectal cancer by administering to a colorectal cancer patient a chemotherapeutic agent that is capable of activating caspase 8, wherein the patient contains a cancer cell that expresses a BaxΔ2 protein (SEQ ID NO. 2).
Bioassay Group, Department of Analytical Biochemistry, MedImmune LLC
Mar 2014 to 2000 Associate Scientist (contractor)Division of Hematology, CBER/FDA Bethesda, MD Apr 2007 to Mar 2014 Research AssociateGeorgetown University Medical Washington, DC May 2006 to Apr 2007 Research Assistant, Department of NeurologyLaboratory of Gene Regulation and Development, NIH/NICHD Bethesda, MD Feb 2006 to May 2006 VolunteerDepartment of Molecular Biology
May 2003 to Mar 2005 Research Associate2nd Affiliated Hospital of Dalian Medical University Dalian, CN Aug 1996 to Jul 1997 Internship
Education:
Kyushu University Apr 2002 to May 2003 PhD in researchKyushu University Apr 2000 to Mar 2002 M.S. in Analytical ChemistryDalian Medical University Dalian, CN Sep 1992 to Jun 1997 Bachelor of Medicine in Clinical and Laboratory Medicine
The University of Chicago, Marine Biological Laboratory, Bell Center for Regenerative Biology & Tissue Engineering
Feb 2014 to 2000 Postdoctoral ScientistUniversity of Maryland, College Park, Department of Biology College Park, MD Feb 2010 to Jan 2014 Postdoctoral Research AssociateChinese Academy of Sciences, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology Kunming, China Jul 2008 to Jan 2010 Research Associate
Education:
Chinese Academy of Sciences, Kunming Institute of Zoology, CAS-Max Planck Junior Scientist Group on Developmental Biology Kunming, China 2005 to 2008 PH.D. in Developmental BiologyLanzhou University, Department of Biology Lanzhou, China 2002 to 2005 M. S. in Developmental BiologyNorth-West Normal University Lanzhou, China 1998 to 2002 B.S in Life Science
Skills:
Molecular cloning; In situ hybridization; Quantitative RT-PCR; RNA synthesis; Protein expression/purification; RACE amplification; Genomic walker; Western blotting; Yeast-two hybrid; Cell culture and transfection; Cell death and proliferation assay;Fish/Xenopus care methods; In vitro fertilization; Embryos collect; Morpholino knock-down and mRNA overexpression; Microinjection; Immunohistochemical Staining; Whole-mount stain for fish bone and cartilage; Oocyte in vitro maturation; Sperm capacitation; In vitro fertilization; Embryos culture; Surgery; Hormone enzyme immunoassay;NGS Sequencing Platforms (Illumina, Pac Bio, etc.); Raw data quality control and processing; De novo genome assembly; RNA-seq differential expression analysis; Transcriptome assembly; Variant detection (SNP and indels); Cloud Computing; Experimental Design; Linux and python training; HPC utilization and job submission