Li Tang

US Patent:

6503741, Jan 7, 2003

Filed:

Aug 28, 1998

Appl. No.:

09/141908

Inventors:

Gary Ashley - Alameda CA
Melanie C. Betlach - Burlingame CA
Mary Betlach - San Francisco CA
Robert McDaniel - Palo Alto CA
Li Tang - Foster City CA

Assignee:

Kosan Biosciences, Inc. - Burlingame CA

International Classification:

C12N 900

US Classification:

435183, 43525233, 43525235, 4352542, 435189, 435193, 435232, 4353201, 536 232, 536 237, 536 231

Abstract:

Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for picromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.

US Patent:

6509455, Jan 21, 2003

Filed:

Sep 7, 2000

Appl. No.:

09/657440

Inventors:

Gary Ashley - Alameda CA
Melanie C. Betlach - Burlingame CA
Mary Betlach - San Francisco CA
Robert McDaniel - Palo Alto CA
Li Tang - Foster City CA

Assignee:

Kosan Biosciences, Inc. - Hayward CA

International Classification:

C07H 2104

US Classification:

536 232, 435193, 4353201, 536 237

Abstract:

Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.

US Patent:

6583290, Jun 24, 2003

Filed:

Nov 28, 2000

Appl. No.:

09/724882

Inventors:

Bryan Julien - Oakland CA
Leonard Katz - Hayward CA
Chaitan Khosla - Palo Alto CA
Li Tang - Foster City CA
Rainer Ziermann - San Mateo CA

Assignee:

Kosam Biosciences, Inc. - Hayward CA

International Classification:

C07D27722

US Classification:

548203, 181205, 5462681

Abstract:

Compounds of the invention include 14-mehtyl epothilone derivatives. More generally, preferred compounds of the invention are those that can be produced by altering the epothilone PKS genes as described herein and optionally by action of epothilone modification enzymes and/or by chemically modifying the resulting epothilones produces when those genes are expressed.

US Patent:

6586116, Jul 1, 2003

Filed:

Feb 9, 2000

Appl. No.:

09/500710

Inventors:

Xiaoping Bian - San Jose CA
Mary Frances Doerner - Santa Cruz CA
Tim Minvielle - San Jose CA
Mohammad Taghi Mirzamaani - San Jose CA
Kai Tang - San Jose CA
Li Tang - Fremont CA

Assignee:

Hitachi Global Storage Technologies Netherlands, B.V. - Amsterdam

International Classification:

G11B 566

US Classification:

428651, 428653, 428668, 428 653, 428 656, 428 657, 428215, 428336, 428694 TS

Abstract:

The design of a magnetic thin film disk, for use in a disk drive, with an amorphous or nanocrystalline pre-seed layer preferably followed by a ruthenium-aluminum (RuAl) seed layer is described. The pre-seed layer may be CrTa or AlTi. The pre-seed layer deposited over a glass substrate, for example, allows a more strongly oriented RuAl seed layer to be deposited and, thus, favorably influences the orientation and grain size in the subsequent layers which include preferably at least one Cr alloy underlayer and at least one magnetic layer.

US Patent:

6838265, Jan 4, 2005

Filed:

May 1, 2001

Appl. No.:

09/847526

Inventors:

Daniel Santi - San Francisco CA, US
Robert McDaniel - Palo Alto CA, US
Li Tang - Foster City CA, US
Chaitan Khosla - Palo Alto CA, US

Assignee:

Kosan Biosciences, Inc. - Hayward CA

International Classification:

C12P 1962

US Classification:

435 76

Abstract:

Generic overproduction host cells can be used to produce any polyketide and obviate the need for performing conventional strain improvement.

US Patent:

6858411, Feb 22, 2005

Filed:

Nov 28, 2000

Appl. No.:

09/724889

Inventors:

Bryan Julien - Oakland CA, US
Leonard Katz - Hayward CA, US
Chaitan Khosla - Palo Alto CA, US
Li Tang - Foster City CA, US
Rainer Ziermann - San Mateo CA, US

Assignee:

Kosan Biosciences, Inc. - Hayward CA

International Classification:

C12P019/62

US Classification:

435 76, 435183, 43525231, 43525233, 536 231, 536 232, 536 237

Abstract:

Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemotherapeutics, fungicides, and immunosuppressants.

US Patent:

6893859, May 17, 2005

Filed:

Apr 2, 2002

Appl. No.:

10/115198

Inventors:

Gary Ashley - Alameda CA, US
Robert L. Arslanian - Pacifica CA, US
John Carney - San Bruno CA, US
Brian Metcalf - Moraga CA, US
Li Tang - Foster City CA, US

Assignee:

KOSAN Biosciences, Inc. - Hayward CA

International Classification:

C12N001/21
C12P017/16

US Classification:

4352523, 4352521, 435118, 435120

Abstract:

This invention relates to compounds of formula (I) and to pharmaceutically acceptable salts and solvates thereof, wherein R, R, R, R, R, W, X, Y, and Ar are as defined herein. Compounds of formula (I) are useful in the treatment of diseases or conditions characterized by cellular hyperproliferation. This invention also relates to means for the preparation of compounds of formula (I); formulations containing compounds of formula (I); and methods for the use of said compounds and formulations in the treatment of a disease or condition characterized by cellular hyperproliferation, including cancer.

US Patent:

6902913, Jun 7, 2005

Filed:

Feb 22, 2001

Appl. No.:

09/793708

Inventors:

Melanie C. Betlach - Burlingame CA, US
Mary Betlach - San Francisco CA, US
Robert McDaniel - Palo Alto CA, US
Li Tang - Foster City CA, US

Assignee:

Kosan Biosciences, Inc. - Hayward CA

International Classification:

C12P019/62
C07H021/04
C12N001/20

US Classification:

435 72, 435 76, 4352523, 43525233, 43525235, 4353201, 536 232, 536 237

Abstract:

Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.