Li W Zheng

US Patent:

7927790, Apr 19, 2011

Filed:

May 24, 2006

Appl. No.:

11/440581

Inventors:

Binghui Shen - Glendora CA, US
Li Zheng - Temple City CA, US

Assignee:

City of Hope - Duarte CA

International Classification:

C12Q 1/70
C12Q 1/68

US Classification:

435 5, 435 6

Abstract:

FEN-1 is involved in processing HIV central DNA flap (CDF) and is a target for intervention of HIV-1 replication. Inhibition of HIV-1 CDF removal by expression of D181A FEN-1 mutant suppresses viral DNA replication, further demonstrating that FEN-1 is a target. Methods of identifying and using molecules that inhibit FEN-1 processing HIV-1 CDF and other methods of inhibiting FEN-1 processing are provided. Useful small molecules specifically suppress FEN-1 cleavage of HIV CDF but have little effect on FEN-1's function in RNA-DNA primer removal. Pentamidine inhibits HIV replication by suppressing FEN-1-mediated HIV-CDF processing.

US Patent:

20210315911, Oct 14, 2021

Filed:

Apr 8, 2021

Appl. No.:

17/225970

Inventors:

- Duarte CA, US
Li Zheng - Duarte CA, US
Karen Reckamp - Duarte CA, US
Ravi Salgia - Duarte CA, US

International Classification:

A61K 31/665
A61K 31/517
A61K 31/5377
A61K 31/506
A61K 31/585
A61P 35/00

Abstract:

Provided herein, inter alia, are methods, compositions and kits for treating cancer in a subject. The methods include administration of one or more tyrosine kinase inhibitors and triptolide or an analog thereof to the subject. The methods, compositions and kits are effective for preventing resistance and/or increasing sensitivity to tyrosine kinase inhibitors.

US Patent:

20190092732, Mar 28, 2019

Filed:

Nov 30, 2018

Appl. No.:

16/206611

Inventors:

- Duarte CA, US
- Pasadena CA, US
Li Zheng - Arcadia CA, US
Hongzhi Li - Duarte CA, US
David Horne - Duarte CA, US
Jun Xie - Duarte CA, US
Kenneth Karanja - Maple Grove MN, US

International Classification:

C07D 215/56
A61K 45/06
A61K 31/47

Abstract:

Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.

US Patent:

20180134664, May 17, 2018

Filed:

Jan 9, 2018

Appl. No.:

15/866268

Inventors:

- Duarte CA, US
- Pasadena CA, US
Li Zheng - Arcadia CA, US
Hongzhi Li - Duarte CA, US
David Horne - Duarte CA, US
Jun Xie - Duarte CA, US
Kenneth Karanja - Maple Grove MN, US

International Classification:

C07D 215/56
A61K 31/47
A61K 45/06

Abstract:

Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.

US Patent:

20170226063, Aug 10, 2017

Filed:

Feb 8, 2017

Appl. No.:

15/428021

Inventors:

- Duarte CA, US
- Pasadena CA, US
Li Zheng - Arcadia CA, US
Hongzhi Li - Duarte CA, US
David Horne - Duarte CA, US
Jun Xie - Duarte CA, US
Kenneth Karanja - Maple Grove MN, US

International Classification:

C07D 215/56
A61K 31/47
A61K 45/06

Abstract:

Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.