Clark Q. Pan - Castro Valley CA, US John E. Murphy - Berkeley CA, US Baisong Mei - Danville CA, US Jonathan S. Strauss - Walnut Creek CA, US Hendri Tjandra - Union City CA, US Jianmin Chen - Concord CA, US Thomas Barnett - Chapel Hill NC, US Liang Tang - Richmond CA, US Deqian Wang - Concord CA, US
Assignee:
Bayer Healthcare LLC - Berkeley CA
International Classification:
A16K 38/00 C12P 21/04
US Classification:
530383, 435 701
Abstract:
This invention relates to Factor VIII muteins that are covalently bound, at one or more predefined sites that are not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity, are capable of correcting human factor VIII deficiencies and have improved pharmacokinetic properties.
A pin for insertion into a hole includes a compliant zone having a first flex-beam and a second flex-beam, the first flex-beam being a predetermined distance from the second flex-beam. The pin further includes a lead-in zone extending from the compliant zone, wherein a width of the lead-in zone narrows to a tip.
Continuation - Site Directed Modification Of Fviii
Clark Q. Pan - Castro Valley CA, US John E. Murphy - Berkeley CA, US Baisong Mei - Danville CA, US Jonathan S. Strauss - Walnut Creek CA, US Hendri Tjandra - Union City CA, US Jianmin Chen - Concord CA, US Thomas Barnett - Chapel Hill NC, US Liang Tang - Richmond CA, US Deqian Wang - Concord CA, US
Assignee:
Bayer HealthCare LLC - Berkeley CA
International Classification:
C07K 14/755 A61K 38/37 C12P 21/02
US Classification:
514 12, 530383, 435 696
Abstract:
This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.
Protein Conjugate Having An Endopeptidase- Cleavable Bioprotective Moiety
The invention is directed to a procoagulant conjugate having an endopeptidase-activatable procoagulant protein moiety and one or more bioprotective moieties, which are conjugated to one another by a linker that is cleaved by an endopeptidase in situ to release the bioprotective moiety. The invention is also directed to therapeutic uses of the procoagulant conjugate and methods of making the conjugate.
John E. Murphy - Berkeley CA, US Baisong Mei - Danville CA, US Jonathan S. Strauss - Walnut Creek CA, US Hendri Tjandra - Union City CA, US Jianmin Chen - Concord CA, US Thomas Barnett - Chapel Hill NC, US Liang Tang - Richmond CA, US Deqian Wang - Concord CA, US
International Classification:
C07K 17/08
US Classification:
530383
Abstract:
This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.
Leveling Sensor In Multiple Charged-Particle Beam Inspection
An improved leveling sensor and method for adjusting a sample height in a charged-particle beam inspection system are disclosed. An improved leveling sensor comprises a light source configured to project a first pattern onto a sample and a detector configured to capture an image of a projected pattern after the first pattern is projected on the sample. The first pattern can comprise an irregularity to enable a determination of a vertical displacement of the sample.
Ranking News Feed Items Using Personalized On-Line Estimates Of Probability Of Engagement
- Mountain View CA, US Liang Tang - Sunnyvale CA, US Guy Lebanon - Menlo Park CA, US
International Classification:
G06F 17/30 G06N 7/00 G06N 99/00
Abstract:
An on-line social network system includes a ranker to processes an inventory of news feed updates for a member and select more relevant updates for presentation to the member. The ranker is trained using training data that includes personalized engagement probability for an update. The personalized engagement probability values are calculated in real time and for a particular update with respect to member features that appear in member profiles maintained by the on-line social network system.
Using Combined Coefficients For Viral Action Optimization In An On-Line Social Network
- Mountain View CA, US Liang Tang - Sunnyvale CA, US Bee-Chung Chen - San Jose CA, US
International Classification:
G06F 17/30 H04L 12/58 H04L 29/08
Abstract:
A news feed system provided with an on-line social network system determines that a news feed is to be constructed for a viewer. The news feed system accesses the viewer's profile and other information associated with the viewer, accesses an inventory of activities that have been identified as potentially of interest to the viewer, and calculates relevance score for each item inventory of activities using the combined coefficients methodology. The activities are then arranged for presentation to the viewer via a news feed web page, using respective calculated relevance scores.
Resumes
Works On Engine Diagnostics, Prognostics And Health Management At Pratt & Whitney
Staff Engineer, Diagnostics, Prognostics and Health Management at Pratt & Whitney
Location:
East Hartford, Connecticut
Industry:
Defense & Space
Work:
Pratt & Whitney - Hartford, CT since Jan 2012
Staff Engineer, Diagnostics, Prognostics and Health Management
Impact Technologies, A Sikorsky Innovations Company - Rochester, NY Sep 2004 - Jan 2012
Team Lead, Intelligent Control & Prediciton
Georgia Institute of Technology - Atlanta, GA. Mar 2003 - Aug 2004
Postdoctoral Research Fellow
Ericsson, Japan - Yokohama, Kanagawa, Japan Sep 2000 - Feb 2003
Project manager
Ericsson/RDC - Shanghai, China Jun 1999 - Aug 2000
Engineer
Education:
Shanghai Jiao Tong University 1994 - 1999
Ph.D., Contorl Theory & Control Engineering
Shanghai Jiao Tong University 1990 - 1994
B.E., Industry Automation
Shanghai Jiao Tong University 1990 - 1994
B.S., Applied Mathematics
Honor & Awards:
● NASA Tech Brief Initial Award for contributing to the development of technical innovation, which has been published as a NASA Tech Brief, entitled “Onboard Nonlinear Engine Sensor and Component Fault Diagnosis and Isolation Scheme” (2010). Link: http://www.techbriefs.com/component/content/article/8994
● Best paper award for paper titled “Impact of Input Uncertainty on Failure Prognostic Algorithms: Extending the Remaining Useful Life of Nonlinear Systems” at the Annual Conference of the Prognostics and Health Management Society (2010)
● Best paper award for the paper “Analysis of Decentralized and Fault-Tolerant Concepts for Distributed Engine Control” presented at the 2010 AIAA/ASME/SAE/ASEE Joint Propulsion Conference (2010)
Ph.d Student In School Of Computing And Information Sciences
Google Sep 1, 2016 - Apr 2019
Senior Software Engineer
Linkedin Jun 30, 2014 - Sep 2016
Senior Software Engineer
Florida International University Aug 2009 - Aug 2014
Ph.d Student In School of Computing and Information Sciences
Linkedin May 2013 - Aug 2013
Applied Research Intern
Ibm May 2012 - Aug 2012
Research Intern
Education:
Florida International University 2009 - 2014
Doctorates, Doctor of Philosophy, Computer Science
Sichuan University 2006 - 2009
Masters, Computer Science
Sichuan University 2002 - 2004
Bachelors, Computer Science
High School Affiliated To Southwest University of China 1999 - 2002
Skills:
Algorithms Machine Learning Data Mining Java C++ Python Hadoop Computer Science Databases Matlab C Sql Information Retrieval Javascript Latex Mysql Jquery Natural Language Processing Weka J2Ee Application Development Mapreduce Postgresql C/C++ Text Mining Eclipse
Interests:
Science and Technology
Languages:
Mandarin English
Certifications:
Neural Networks and Deep Learning Improving Deep Neural Networks: Hyperparameter Tuning, Regularization and Optimization Structuring Machine Learning Projects Convolutional Neural Networks