Liangliang A Sun

US Patent:

20190004010, Jan 3, 2019

Filed:

Sep 22, 2017

Appl. No.:

15/741883

Inventors:

- South Bend IN, US
Guijie ZHU - South Bend IN, US
Liangliang SUN - South Bend IN, US

Assignee:

UNIVERSITY OF NOTRE DAME DU LAC - South Bend IN

International Classification:

G01N 27/447
G01N 30/72
C07K 1/28

Abstract:

The invention provides a capillary isoelectric focusing (cIEF) system based on a sandwich injection method for automated chemical mobilization. This system was coupled with an electrokinetically pumped nanoelectrospray interface to a mass spectrometer. The nanoelectrospray emitter employed an acidic sheath electrolyte. To realize automated focusing and mobilization, a plug of ammonium hydroxide was first injected into the capillary, followed by a section of mixed sample and ampholyte. As focusing progressed, the NHHO section was titrated to lower pH buffer by the acidic sheath buffer. Chemical mobilization started automatically once the ammonium hydroxide was consumed by the acidic sheath flow electrolyte.

US Patent:

20170363576, Dec 21, 2017

Filed:

Jun 20, 2016

Appl. No.:

15/187482

Inventors:

- Notre Dame IN, US
Guijie ZHU - South Bend IN, US
Liangliang SUN - South Bend IN, US

Assignee:

University of Notre Dame du Lac - Notre Dame IN

International Classification:

G01N 27/447
B05D 7/22

Abstract:

The invention provides a novel method of coating the inside of a capillary with a polymeric material. The method can include introducing a catalyst-free solution of a monomer and initiator, wherein the monomer is present in about 1-10% (w/v) and the initiator is present in 0.1-1% (w/v), into a capillary and thermally initiating polymerization of the monomer thereby providing a capillary comprising an internal polymeric coating for separating, identifying, and quantifying components of an analyte.

US Patent:

20150311056, Oct 29, 2015

Filed:

Jul 7, 2015

Appl. No.:

14/793566

Inventors:

- Notre Dame IN, US
Liangliang Sun - South Bend IN, US
Guijie Zhu - South Bend IN, US

Assignee:

University of Notre Dame de Lac - Notre Dame IN

International Classification:

H01J 49/16
H01J 49/00
G01N 30/72
H01J 49/04
G01N 27/447

Abstract:

The invention provides a sheath-flow interface for producing electrospray from a capillary. The electrospray generated by the interface can be used as the source of ions for mass spectrometry. Electrokinetic flow in the interface can move a sheath liquid past the end of a capillary so as to mix with an analyte effluent discharged from the capillary. The sheath liquid and analyte mixture can be directed to an electrospray emitter to generate an electrospray.

US Patent:

20150233877, Aug 20, 2015

Filed:

Apr 5, 2015

Appl. No.:

14/679009

Inventors:

- Notre Dame IN, US
Liangliang Sun - South Bend IN, US
Guijie Zhu - South Bend IN, US

Assignee:

UNIVERSITY OF NOTRE DAME DU LAC - Notre Dame IN

International Classification:

G01N 30/72
H01J 49/04
H01J 49/16
G01N 27/447

Abstract:

The invention provides a sheath-flow interface for producing electrospray from a capillary. The electrospray generated by the interface can be used as the source of ions for mass spectrometry. Electrokinetic flow in the interface can move a sheath liquid past the end of a capillary so as to mix with an analyte effluent discharged from the capillary. The sheath liquid and analyte mixture can be directed to an electrospray emitter to generate an electrospray.