Jayasree Vasudevan - Anaheim CA Alan T. Johnson - San Diego CA Liming Wang - Irvine CA Roshantha A. Chandraratna - Laguna Hills CA
Assignee:
Allergan Sales, Inc. - Irvine CA
International Classification:
A61K 3124
US Classification:
514567, 514538, 560 43, 562456, 562457
Abstract:
Compounds having Formula 4 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.
Methods Of Providing And Using Compounds Having Activity As Inhibitors Of Cytochrome P450Rai
Jayasree Vasudevan - Anaheim CA Alan T. Johnson - San Diego CA Liming Wang - Irvine CA Dehua Huang - San Diego CA Roshantha A. Chandraratna - Laguna Hills CA
Novel compounds having the Formulas 1 through 8, wherein the symbols have the meaning defined in the specification, and certain previously known compounds have been discovered to act as inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. The compound can also be used in co-treatment with retinoids.
Compounds Having Activity As Inhibitors Of Cytochrome P450Rai
Jayasree Vasudevan - Anaheim CA Alan T. Johnson - San Diego CA Liming Wang - Irvine CA Dehua Huang - San Diego CA Roshantha A. Chandraratna - Laguna Hills CA
Compounds having Formulas 5 and 6 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.
Methods Of Providing And Using Compounds Having Activity As Inhibitors Of Cytochrome P450Rai
Jayasree Vasudevan - Anaheim CA Alan T. Johnson - San Diego CA Liming Wang - Irvine CA Dehua Huang - San Diego CA Roshantha A. Chandraratna - Laguna Hills CA
Assignee:
Allergan, Inc. - Irvine CA
International Classification:
A61K 31495
US Classification:
51425204, 514269, 514306
Abstract:
Novel compounds having the Formulas 1 through 8, wherein the symbols have the meaning defined in the specification, and certain previously known compounds have been discovered to act as inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. The compound can also be used in co-treatment with retinoids.
1-Imidazolyl Substituted Tetrahydronaphthalene Derivatives As Inhibitors Of Eytochrome P450Rai
Jayasree Vasudevan - Anaheim CA Alan T. Johnson - San Diego CA Liming Wang - Irvine CA Roshantha A. Chandraratna - Laguna Hills CA
Assignee:
Allergan, Inc. - Irvine CA
International Classification:
C07D23364
US Classification:
5483415, 5483451
Abstract:
Compounds having Formula 4 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.
Compounds Having Activity As Inhibitors Of Cytochrome P450Rai
Jayasree Vasudevan - Anaheim CA Alan T. Johnson - San Diego CA Liming Wang - Irvine CA Roshantha A. Chandraratna - Laguna Hills CA
Assignee:
Allergan, Inc. - Irvine CA
International Classification:
C07C22946
US Classification:
562457
Abstract:
Compounds having Formula 4 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.
4-[(8-Ethynyl, 8-Vinyl Or 8-Ethynyl-Methyl)-6-Chromanoyl]-Benzoic And 2-[4-[(8-Ethynyl, 8-Vinyl Or 8-Ethynyl-Methyl)-6-Chromanoyl]-Phenyl]-Acetic Acid, Their Esters And Salts Having Cytochrome P450Rai Inhibitory Activity
Compounds of Formula 1: wherein the variables are defined in the specification have cytochrome P450RAI-1 and P450RAI-2 inhibitory activity, and are suitable for treatment of mammals with conditions which are treatable with retinoids, or which are controlled by or responsive to the organisms native retinoic acid. Formulations containing the compounds of the invention can also be co-administered with retinoids and/or Vitamin A to enhance or prolong the effects of medications containing retinoids, Vitamin A, or of the organisms native retinoic acid.
Methods For Identifying Inhibitors Of Cytochrome P450Rai
Jayasree Vasudevan - Anaheim CA, US Alan T. Johnson - San Diego CA, US Liming Wang - Irvine CA, US Dehua Huang - San Diego CA, US Roshantha A. Chandraratna - Laguna Hills CA, US
Assignee:
Allergan, Inc. - Irvine CA
International Classification:
C12Q001/26
US Classification:
435 25, 546160
Abstract:
A method of identifying a compound which is an inhibitor of the enzyme cytochrome P450RAI is performed by selecting a compound that has retinoid activity in an art recognized assay and includes a benzoic acid, benzoic acid ester, naphthoic acid ester or heteroaryl carboxylic acid or ester moiety, with a partial structure of —A(R)—(CH)where n is 0 and the remaining variables are as described in the specification and claims. Thereafter, a compound having the cytochrome P450RAI inhibitory activity is identified and selected where the compound has the —A(R)—(CH)—COORpartial structure wherein the variable n is 1 or 2.
Name / Title
Company / Classification
Phones & Addresses
Liming Wang President
SUNUP DEVELOP CORPORATION Business Services at Non-Commercial Site
232 Macalester Dr, Walnut, CA 91789
Liming Wang President
THE FOOD MUSE INC
2223 W Commonwealth Ave, Alhambra, CA 91803
Liming Wang Chief Exec, Chief Executive Offi, Director, Secretary, Treasurer
TISA INTERNATIONAL TRADING LLC
385 S Lemon Ave #E276, Walnut, CA 91789 3592 Rosemead Blvd, Rosemead, CA 91770 815 Brazos St, Austin, TX 78701
Liming Wang
SINO-AM CULTURE & ARTS CENTER OF NORTH AMERICA
Liming Wang President
DADI DESIGN MATERIALS CORP
121 S Del Mar Ave STE C-3, San Gabriel, CA 91776
Liming Wang Nursing Director
Longwood Management Corp Convalescent Home With Continueous Nursing Care · Nursing/Personal Care Skilled Nursing Care Facility
537 W Live Oak St, San Gabriel, CA 91776 (626)2895510, (626)2893763
UC Berkeley - Berkeley, CA since Jan 2012
Bowes Research Fellow
California Institute of Technology - Pasadena, CA Jul 2011 - Dec 2011
Visiting Scholar
National Institute of Biological Sciences - Beijing, China Jan 2005 - Oct 2005
Technician
Education:
California Institute of Technology 2006 - 2011
Ph.D., Biology
Peking University 2001 - 2005
B.S., Biological Sciences
Honor & Awards:
Lawrence L. and Audrey W. Ferguson Prize for Outstanding Doctoral Thesis in Biology, California Institute of Technology, 2011
Chinese Government Award for Outstanding Self-Financed Students Abroad, 2011
Li-Ming Scholarship, California Institute of Technology, 2007
Shu Juan Scholarship, Peking University, 2003-2004
President's Undergraduate Research Grant, Peking University, 2003-2005
Languages:
English Mandarin Chinese
Youtube
Dr. Liming Wang on An Overview of the Chinese...
About the event: On 1 September, the IIEA hosted a joint seminar with ...
Duration:
22m 59s
Changed from Charity | Liming Wang | TEDxSuzhou
In the spirit of ideas worth spreading, TEDx is a program of local, se...
Duration:
17m 45s
Dr. Liming Wang on Rising China in the Changi...
About the Speech: Dr Wang officially launched the book, "Rising China ...
Duration:
35m 57s
Teaching Demo--Liming Wang
Duration:
1h 50s
Psychiatric "Wife" Li Li Today Starts Her Psy...
Psychiatric Li Li on Her Intentional PSYCHOPATHIC DISPLAY Again April ...
Duration:
5m 24s
Lily's (Liming Wang) TV gig in Shanghai
My TV show role in Shanghai. Dialogue in Shanghainese. Aired July 9th,...
"The next question to be answered is the precise mechanism by which the gut microbiome and the brain communicate in obese people, including during weight loss," said Liming Wang, a paper co-author and a researcher at Beijing's Health Management Institute.
Date: Dec 20, 2023
Category: Health
Source: Google
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Liming Wang
Lived:
Pasadena, ca Beijing, china Luoyang, china
Work:
University of California, Berkeley - Bowes Research Fellow (2011) California Institute of Technology - Visiting Scholar (2011) California Institute of Technology - Technician (2005-2006) National Institute of Biological Sciences, Beijing - Technician (2005-2005)
Education:
California Institute of Technology - Biology, Peking University - Biological Sciences, Luoyang No.1 High School, Luoyang Experimental Junior High, Luoyang Experimental Primary School