Liming Chun Wang

US Patent:

7656523, Feb 2, 2010

Filed:

Jun 30, 2006

Appl. No.:

11/477379

Inventors:

Lei Sun - Santa Clara CA, US
Liming Wang - Sunnyvale CA, US

Assignee:

Intel Corporation - Santa Clara CA

International Classification:

G01J 3/44

US Classification:

356301, 356302

Abstract:

A device (and methods of using and manufacturing the device) that utilize a plurality of photomultipliers (PMT)s or a photodiodes coupled with a set of filters to collect Raman signal from samples. Also a method of detecting Raman signals includes receiving Raman signals from a sample utilizing a plurality of photomultiplier tubes (PMT)s or photodiodes, wherein at least one PMT or photodiode provides a different Raman signal than at least one other PMT or photodiode.

US Patent:

7820454, Oct 26, 2010

Filed:

Dec 29, 2006

Appl. No.:

11/647578

Inventors:

Xing Su - Cupertino CA, US
Kenneth Swartz - Mountain View CA, US
Liming Wang - Sunnyvale CA, US
David Eric Schwartz - New York NY, US
Mineo Yamakawa - Campbell CA, US

Assignee:

Intel Corporation - Santa Clara CA

International Classification:

G01N 33/553

US Classification:

436526

Abstract:

An embodiment of the invention relates to a device comprising (1) an array of electromagnetic elements comprising coils, metal cores, and metal core heads, and (2) a controller that is adapted to control a current for one or more coils individually, to vary the current for said one or more coils individually, to reverse the current for one or more coils individually, and to generate a specific magnetic flux distribution and gradient across two or more coils; wherein the metal core head is at one end of the coil and the metal core head has a geometry to create a desired magnetic flux, intensity and gradient, in a region of interest between two adjacent coils; further wherein the device is functionally coupled to a fluidic device to concentrate and transport magnetic particles in a fluid without fluidic movement of the fluid.

US Patent:

8090424, Jan 3, 2012

Filed:

Jan 10, 2006

Appl. No.:

11/330406

Inventors:

Dale E. Winther - Livermore CA, US
Liming Wang - Fremont CA, US
Runchuan Zhao - Fremont CA, US

Assignee:

STI Medical Systems, LLC - La Jolla CA

International Classification:

A61B 5/1455

US Classification:

600319

Abstract:

An apparatus for determine a glucose level having a calibration module; an image acquisition module; an image compensation module; and, a dynamic pattern matching module. A method using the apparatus is also described.

US Patent:

8105848, Jan 31, 2012

Filed:

Oct 8, 2010

Appl. No.:

12/900826

Inventors:

Xing Su - Cupertino CA, US
Kenneth Schwartz - Mountain View CA, US
Liming Wang - Sunnyvale CA, US
David Schwartz - Brooklyn NY, US
Mineo Yamakawa - Campbell CA, US

Assignee:

Intel Corporation - Santa Clara CA

International Classification:

G01N 33/53

US Classification:

436526, 210695, 21074801, 21074805, 210222, 210243, 204155, 204556, 204557, 204664, 436164, 422 50, 422 681

Abstract:

An embodiment of the invention relates to a device comprising (1) an array of electromagnetic elements comprising coils, metal cores, and metal core heads, and (2) a controller that is adapted to control a current for one or more coils individually, to vary the current for said one or more coils individually, to reverse the current for one or more coils individually, and to generate a specific magnetic flux distribution and gradient across two or more coils; wherein the metal core head is at one end of the coil and the metal core head has a geometry to create a desired magnetic flux, intensity and gradient, in a region of interest between two adjacent coils; further wherein the device is functionally coupled to a fluidic device to concentrate and transport magnetic particles in a fluid without fluidic movement of the fluid.

US Patent:

8194244, Jun 5, 2012

Filed:

Jun 29, 2007

Appl. No.:

11/770945

Inventors:

Liming Wang - Sunnyvale CA, US
Grace Credo - San Mateo CA, US

Assignee:

Intel Corporation - Santa Clara CA

International Classification:

G01J 3/44

US Classification:

356301

Abstract:

Devices, methods of using the device, systems including the device that include a sample plate with sample containers (wells), wherein at least a portion of the surface of the sample plate and/or sample containers is coated with an optical reflective material. The optical reflective material, provides enhanced excitation signal intensity and enhanced Raman signal intensity. Such enhancement provides improved total signal detection capabilities, and methods of improved focusing algorithms.

US Patent:

20100330553, Dec 30, 2010

Filed:

Jun 30, 2009

Appl. No.:

12/459309

Inventors:

Xing Su - Cupertino CA, US
Liming Wang - Santa Clara CA, US
Jianquan Liu - Fremont CA, US
Kai Wu - Mountain View CA, US

International Classification:

C12Q 1/68
C12M 1/00
G02B 6/10

US Classification:

435 6, 4352872, 385129

Abstract:

Methods for sequencing nucleic acids are presented. Sequencing is accomplished through the chemical amplification of the products of DNA synthesis and the detection of the chemically amplified products. In embodiments of the invention, a substrate is provided having a plurality of molecules of DNA to be sequenced attached and a plurality of molecules capable of chelating pyrophosphate ions attached, the DNA molecules to be sequenced are primed, and a next complementary nucleotide is incorporated and excised a plurality of times leading to the buildup of pyrophosphate ions locally around the DNA molecule to be sequenced. Pyrophosphate ions are captured by the substrate-attached chelators and optically detected to determine the identity of the next complementary nucleic acid in the DNA molecule to be sequenced.

US Patent:

20120046176, Feb 23, 2012

Filed:

Aug 20, 2010

Appl. No.:

12/860462

Inventors:

Xing Su - Cupertino CA, US
Kai Wu - Mountain View CA, US
Liming Wang - Santa Clara CA, US
Jianquan Liu - Fremont CA, US
Grace M. Credo - San Mateo CA, US

International Classification:

C40B 20/00

US Classification:

506 2

Abstract:

Nucleic acid sequencing using concatemers of DNA is provided. Optionally, amplified reaction products from the repeated incorporation and excision of a nucleoside complementary to a nucleoside of the DNA to be sequenced onto primer molecules hybridized to the concatemers of DNA are detected. Nucleic acid sequencing using concatemers of DNA and non-natural oligonucleotides is also provided. Nucleic acid sequencing reactions are detected electronically and or optically using arrays of detectors.

US Patent:

20120274936, Nov 1, 2012

Filed:

May 31, 2012

Appl. No.:

13/485298

Inventors:

Liming Wang - Sunnyvale CA, US
Grace Credo - San Mateo CA, US

International Classification:

G01J 3/44
G01N 21/01

US Classification:

356301, 356244

Abstract:

Devices, methods of using the device, systems including the device that include a sample plate with sample containers (wells), wherein at least a portion of the surface of the sample plate and/or sample containers is coated with an optical reflective material. The optical reflective material, provides enhanced excitation signal intensity and enhanced Raman signal intensity. Such enhancement provides improved total signal detection capabilities, and methods of improved focusing algorithms.