Lin Lin Chen

US Patent:

8076070, Dec 13, 2011

Filed:

Aug 6, 2009

Appl. No.:

12/537138

Inventors:

Lin Chen - Los Angeles CA, US
Reza Kalhor - Los Angeles CA, US

Assignee:

University of Southern California - Los Angeles CA

International Classification:

C12Q 1/68
G01N 33/53
C12P 19/34
C07H 21/00
C07H 21/02
C07H 21/04

US Classification:

435 6, 435 71, 435 912, 536 221, 536 231, 536 243

Abstract:

The invention relates to the use of GCC (Genome Conformation Capture) technology in determining the three dimensional arrangement of an entire genome.

US Patent:

20020180753, Dec 5, 2002

Filed:

Jun 4, 2001

Appl. No.:

09/871632

Inventors:

Lin Chen - La Canada CA, US

International Classification:

G09G005/02

US Classification:

345/591000

Abstract:

A method of establishing a color image space model including the steps of: (a) setting a standard color card containing a series of reference colors for use as a color data bank, and then setting a table of relative adjectives; (b) setting a color comment questionnaire subject to the standard color card and table of relative objectives thus obtained; (c) selecting at least one particular group people to make an investigation subject to the set color comment questionnaire, and then collecting and arranging the investigation result thus obtained so as to set up effective statistic data; and (d) using an analysis mode to compute the effective statistic data thus obtained, so as to establish a specific color image space model.

US Patent:

20110275674, Nov 10, 2011

Filed:

Nov 5, 2009

Appl. No.:

12/613521

Inventors:

Lin Chen - La Canada CA, US
Nimanthi Jayathilaka - Los Angeles CA, US
Aidong Han - Los Angeles CA, US
Nicos A. Petasis - Hacienda Heights CA, US

Assignee:

UNIVERSITY OF SOUTHERN CALIFORNIA - Los Angeles CA

International Classification:

A61K 31/444
C07C 237/20
C12Q 1/68
C12N 15/63
C12N 5/07
G06G 7/58
A61K 31/167
A61P 35/00
A61P 25/28
A61P 9/00
G01N 33/68
C07D 401/12
C12N 9/99

US Classification:

514332, 546265, 564157, 435 613, 4353201, 435375, 435184, 514616, 436501, 703 11

Abstract:

Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to specific DNA promoters. The targeted transcription factors include but are not limited to the myocyte enhancing factor (MEF2), the forkhead/winged helix transcription factor FOXP3 and the transcription factor GATA3. Also disclosed are small molecule modulators of MEF2 and its associated factors that include but not limited to histone deacetylases (HDACs), p300/CBP and Cabin1 and the therapeutic applications thereof.

US Patent:

20110287947, Nov 24, 2011

Filed:

May 18, 2010

Appl. No.:

12/782616

Inventors:

Lin Chen - Los Angeles CA, US
Reza Kalhor - Los Angeles CA, US

Assignee:

UNIVERSITY OF SOUTHERN CALIFORNIA - Los Angeles CA

International Classification:

C40B 30/00
C12Q 1/68

US Classification:

506 7, 435 619

Abstract:

Disclosed are methods and systems for determining the three-dimensional structure of chromatin in eukaryotic cells. More specifically, disclosed are methods and systems for obtaining chromatin structural information by surface immobilization, i.e tethering crosslinked protein:DNA complexes and/or ligated DNA complexes to media such as beads, gels, and or matrices during the conformation capture assay. In general, the method includes contacting a cell with a cross-linking reagent to cross-link DNA and protein in the cell; lysing the cell, producing cross-linked protein:DNA complexes by cutting the chromatin using a chemical, physical or enzymatic method, substantially immobilizing the cross-linked protein:DNA complexes, ligating the cross-linked protein:DNA complexes intramolecularly such that the ligated protein:DNA complexes represent structural organization of the chromatin; characterizing the ligated DNA by sequencing or other methods; and identifying any structural organization of the chromatin. The structural organization preferably includes information relating to interacting loci of the chromatin.

US Patent:

20200071746, Mar 5, 2020

Filed:

Dec 8, 2017

Appl. No.:

16/467941

Inventors:

- Los Angeles CA, US
Lin Chen - Los Angeles CA, US

International Classification:

C12Q 1/6806
A01N 1/02
G16B 15/00
C12Q 1/6869

Abstract:

Disclosed are methods and systems for determining the three-dimensional structure of chromatin in eukaryotic cells. More specifically, disclosed are methods and systems for obtaining chromatin structural information by surface immobilization that includes tethering crosslinked protein:DNA complexes and/or ligated DNA complexes to media such as beads, gels, and or matrices during the conformation capture assay. In general, the method includes flash freezing a cell such that the structural organization of the chromatin or other protein:DNA complexes is preserved, cryomilling the cell, producing cross-linked protein:DNA complexes by cutting the chromatin using a chemical, physical or enzymatic method, substantially immobilizing the cross-linked protein:DNA complexes, ligating the cross-linked protein:DNA complexes intramolecularly such that the ligated protein:DNA complexes represent structural organization of the chromatin; characterizing the ligated DNA by sequencing or other methods; and identifying any structural organization of the chromatin. The structural organization preferably includes information relating to interacting loci of the chromatin.

US Patent:

20190247376, Aug 15, 2019

Filed:

Sep 29, 2017

Appl. No.:

16/336879

Inventors:

- Los Angeles CA, US
Lin CHEN - Los Angeles CA, US

International Classification:

A61K 31/444
A61K 45/06
A61P 29/00
G01N 33/50

Abstract:

This disclosure provides methods and compositions for treating diseases and disorders by targeting ILC2s that express the α7-nicotinic acetylcholine receptor (α7nAChR).