Lin Jing Chen

US Patent:

8076070, Dec 13, 2011

Filed:

Aug 6, 2009

Appl. No.:

12/537138

Inventors:

Lin Chen - Los Angeles CA, US
Reza Kalhor - Los Angeles CA, US

Assignee:

University of Southern California - Los Angeles CA

International Classification:

C12Q 1/68
G01N 33/53
C12P 19/34
C07H 21/00
C07H 21/02
C07H 21/04

US Classification:

435 6, 435 71, 435 912, 536 221, 536 231, 536 243

Abstract:

The invention relates to the use of GCC (Genome Conformation Capture) technology in determining the three dimensional arrangement of an entire genome.

US Patent:

20110287947, Nov 24, 2011

Filed:

May 18, 2010

Appl. No.:

12/782616

Inventors:

Lin Chen - Los Angeles CA, US
Reza Kalhor - Los Angeles CA, US

Assignee:

UNIVERSITY OF SOUTHERN CALIFORNIA - Los Angeles CA

International Classification:

C40B 30/00
C12Q 1/68

US Classification:

506 7, 435 619

Abstract:

Disclosed are methods and systems for determining the three-dimensional structure of chromatin in eukaryotic cells. More specifically, disclosed are methods and systems for obtaining chromatin structural information by surface immobilization, i.e tethering crosslinked protein:DNA complexes and/or ligated DNA complexes to media such as beads, gels, and or matrices during the conformation capture assay. In general, the method includes contacting a cell with a cross-linking reagent to cross-link DNA and protein in the cell; lysing the cell, producing cross-linked protein:DNA complexes by cutting the chromatin using a chemical, physical or enzymatic method, substantially immobilizing the cross-linked protein:DNA complexes, ligating the cross-linked protein:DNA complexes intramolecularly such that the ligated protein:DNA complexes represent structural organization of the chromatin; characterizing the ligated DNA by sequencing or other methods; and identifying any structural organization of the chromatin. The structural organization preferably includes information relating to interacting loci of the chromatin.

US Patent:

20230086995, Mar 23, 2023

Filed:

Sep 20, 2021

Appl. No.:

17/479832

Inventors:

- Kirkland WA, US
Steve Skeoch - Palos Verdes Estates CA, US
Lin Chen - Seattle WA, US
Zhongwei Cheng - Redmond WA, US

International Classification:

H01R 33/945
H01R 33/92
H04N 7/18

Abstract:

A lamp socket assembly to be installed in a light socket and receive electrical power therefrom. The lamp socket assembly to provide electrical power to a surveillance device that detects an occurrence of a security event and notifies the lamp socket assembly of the occurrence. In response to the notification, the lamp socket assembly to turn on a light bulb.

US Patent:

20200071746, Mar 5, 2020

Filed:

Dec 8, 2017

Appl. No.:

16/467941

Inventors:

- Los Angeles CA, US
Lin Chen - Los Angeles CA, US

International Classification:

C12Q 1/6806
A01N 1/02
G16B 15/00
C12Q 1/6869

Abstract:

Disclosed are methods and systems for determining the three-dimensional structure of chromatin in eukaryotic cells. More specifically, disclosed are methods and systems for obtaining chromatin structural information by surface immobilization that includes tethering crosslinked protein:DNA complexes and/or ligated DNA complexes to media such as beads, gels, and or matrices during the conformation capture assay. In general, the method includes flash freezing a cell such that the structural organization of the chromatin or other protein:DNA complexes is preserved, cryomilling the cell, producing cross-linked protein:DNA complexes by cutting the chromatin using a chemical, physical or enzymatic method, substantially immobilizing the cross-linked protein:DNA complexes, ligating the cross-linked protein:DNA complexes intramolecularly such that the ligated protein:DNA complexes represent structural organization of the chromatin; characterizing the ligated DNA by sequencing or other methods; and identifying any structural organization of the chromatin. The structural organization preferably includes information relating to interacting loci of the chromatin.

US Patent:

20190247376, Aug 15, 2019

Filed:

Sep 29, 2017

Appl. No.:

16/336879

Inventors:

- Los Angeles CA, US
Lin CHEN - Los Angeles CA, US

International Classification:

A61K 31/444
A61K 45/06
A61P 29/00
G01N 33/50

Abstract:

This disclosure provides methods and compositions for treating diseases and disorders by targeting ILC2s that express the α7-nicotinic acetylcholine receptor (α7nAChR).

US Patent:

20140220527, Aug 7, 2014

Filed:

Feb 6, 2014

Appl. No.:

14/174372

Inventors:

Baoxin Li - Chandler AZ, US
Peng Zhang - Tempe AZ, US
Qiang Zhang - Tempe AZ, US
Lin Chen - Tempe AZ, US

Assignee:

AZ Board of Regents, a body corporate of the State of AZ, acting for & on behalf of AZ State - Scottsdale AZ

International Classification:

G09B 9/00

US Classification:

434262

Abstract:

An intelligent system that supports real-time and offline feedback based on automated analysis of a trainee's performance using data streams captured in the training process is disclosed.