Lin Lin

US Patent:

6445133, Sep 3, 2002

Filed:

Jul 23, 2001

Appl. No.:

09/910561

Inventors:

Lin Lin - Alsip IL
Thomas S. Hendrickson - Crestwood IL

Assignee:

Litetronics International, Inc. - Alsip IL

International Classification:

H01J 1346

US Classification:

315 57, 315 58, 315209 R, 315255, 315362, 362265, 362448

Abstract:

An incandescent lamp is designed to operate at lower than the AC line voltage and includes a voltage conversion circuit for lowering the line voltage to the operating voltage of the lamp. The circuit includes an output transformer which is disposed in the screw base of the lamp, the remainder of the circuit, which is high-temperature-intolerant, being disposed outside the base and the envelope of the lamp. In a reflectorized embodiment of the lamp, the high-temperature-intolerant portion of the circuit is disposed adjacent to the mouth of the reflector envelope on the outer surface thereof and, in a non-reflectorized bulb embodiment, the high-temperature-intolerant portion is disposed between the envelope and a skirt which is connected to the base.

US Patent:

59773855, Nov 2, 1999

Filed:

Jul 15, 1998

Appl. No.:

9/115984

Inventors:

Michael T. Flavin - Darien IL
Ze-Qi Xu - Naperville IL
Albert Khilevich - Glenview IL
David Zembower - Oak Park IL
John D. Rizzo - Downers Grove IL
Shuyuan Liao - Glen Ellyn IL
Aye Mar - Chicago IL
Lin Lin - Chicago IL
Vilayphone Vilaychack - Elgin IL
Darko Brankovic - Bolingbrook IL
Sergey Dzekhster - Chicago IL
Jinjun Liu - Naperville IL

Assignee:

Sarawak MediChem Pharmaceuticals - Lemont IL

International Classification:

C07D49300

US Classification:

549282

Abstract:

A method of preparing (+)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. According to the disclosed method, chromene 4 intermediate was subjected to a chlorotitanium-mediated aldol reaction with acetaldehyde to selectively produce (. +-. )-8a. Separation and enzyme-mediated resolution of (. +-. )-8a produced (+)-8a. Cyclization of (+)-8a under neutral Mitsunobu conditions followed by Luche reduction of (+)-7 produced (+)-calanolide A in high yield and enantiomeric purity. The method of the invention has been extended to produce potent antiviral calanolide A analogues.

US Patent:

59817704, Nov 9, 1999

Filed:

Sep 5, 1997

Appl. No.:

8/924840

Inventors:

Michael T. Flavin - Darien IL
Ze-Qi Xu - Naperville IL
Albert Khilevich - Glenview IL
David Zembower - Oak Park IL
John D. Rizzo - Downers Grove IL
Shuyuan Liao - Glen Ellyn IL
Aye Mar - Chicago IL
Lin Lin - Chicago IL
Vilayphone Vilaychack - Elgin IL
Darko Brankovic - Bolingbrook IL
Sergey Dzekhster - Chicago IL
Jinjun Liu - Naperville IL

Assignee:

Sarawak MediChem Pharmaceuticals, Inc. - Lemont IL

International Classification:

C07D49300

US Classification:

549282

Abstract:

A method of preparing (+)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. According to the disclosed method, chromene 4 intermediate was subjected to a chlorotitanium-mediated aldol reaction with acetaldehyde to selectively produce (. +-. )-8a. Separation and enzyme-mediated resolution of (. +-. )-8a produced (+)-8a. Cyclization of (+)-8a under neutral Mitsunobu conditions followed by Luche reduction of (+)-7 produced (+)-calanolide A in high yield and enantiomeric purity. The method of the invention has been extended to produce potent antiviral calanolide A analogues.

US Patent:

60432713, Mar 28, 2000

Filed:

Aug 2, 1995

Appl. No.:

8/510213

Inventors:

Michael T. Flavin - Darien IL
Ze-Qi Xu - Naperville IL
John D. Rizzo - Downers Grove IL
Alla Kucherenko - Naperville IL
Albert Khilevich - Glenview IL
Abram Kivovich Sheinkman - Naperville IL
Vilayphone Vilaychack - Elgin IL
Lin Lin - Chicago IL
Wei Chen - Naperville IL
William A. Boulanger - Schenectady NY

Assignee:

Sarawak MediChem Pharmaceuticals, Inc. - Lemont IL

International Classification:

A61K 3135
C07D40700

US Classification:

514453

Abstract:

A method of preparing (. +-. )-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. Useful intermediates for preparing (. +-. )-calanolide A and its derivatives are also provided. According to the disclosed method, chromene 4 intermediate was reacted with acetaldehyde diethyl acetal or paraldehyde in the presence of an acid catalyst with heating, or a two-step reaction including an aldol reaction with acetaldehyde and cyclization either under acidic conditions or neutral Mitsunobu conditions, to produce chromanone 7. Reduction of chromanone 7 with sodium borohydride, in the presence of cerium trichloride, produced (. +-. )-calanolide A. A method for resolving (. +-. )-calanolide A into its optically active forms by a chiral HPLC system or by enzymatic acylation and hydrolysis is also disclosed. Finally, a method for treating or preventing a viral infections using (. +-.

US Patent:

58745912, Feb 23, 1999

Filed:

Sep 9, 1997

Appl. No.:

8/925707

Inventors:

Michael T. Flavin - Darien IL
Ze-Qi Xu - Naperville IL
Vilayphone Vilaychack - Elgin IL
Lin Lin - Chicago IL

Assignee:

Sarawak MediChem Pharmaceuticals, Inc. - Lemont IL

International Classification:

C07D49300

US Classification:

549282

Abstract:

A method of preparing (. +-. )-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. Useful intermediates for preparing (. +-. )-calanolide A and its derivatives are also provided. According to the disclosed method, chromene 4 intermediate was reacted with acetaldehyde diethyl acetal or paraldehyde in the presence of an acid catalyst with heating, or a two-step reaction including an aldol reaction with acetaldehyde and cyclization either under acidic conditions or neutral Mitsunobu conditions, to produce chromanone 7. Reduction of chromanone 7 with sodium borohydride, in the presence of cerium trichloride, produced (. +-. )-calanolide A. A method for resolving (. +-. )-calanolide A into its optically active forms by a chiral HPLC system or by enzymatic acylation and hydrolysis is also disclosed. Finally, a method for treating or preventing viral infections using (. +-.

US Patent:

58920609, Apr 6, 1999

Filed:

Mar 1, 1996

Appl. No.:

8/609537

Inventors:

Michael T. Flavin - Darien IL
Ze-Qi Xu - Naperville IL
Albert Khilevich - Glenview IL
David Zembower - Oak Park IL
John D. Rizzo - Downers Grove IL
Shuyuan Liao - Glen Ellyn IL
Aye Mar - Chicago IL
Lin Lin - Chicago IL
Darko Brankovic - Bolingbrook IL
Sergey Dzekhster - Chicago IL
Jinjun Liu - Naperville IL

Assignee:

Sarawak MediChem Pharmaceuticals, Inc. - Lemont IL

International Classification:

C07D40714

US Classification:

549277

Abstract:

A method of preparing (+)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. According to the disclosed method, chromene 4 intermediate was subjected to a chlorotitanium-mediated aldol reaction with acetaldehyde to selectively produce (. +-. )-8a. Separation and enzyme-mediated resolution of (. +-. )-8a produced (+)-8a. Cyclization of (+)-8a under neutral Mitsunobu conditions followed by Luche reduction of (+)-7 produced (+)-calanolide A in high yield and enantiomeric purity. The method of the invention has been extended to produce potent antiviral calanolide A analogues.

US Patent:

58722645, Feb 16, 1999

Filed:

Sep 5, 1997

Appl. No.:

8/924803

Inventors:

Michael T. Flavin - Darien IL
Ze-Qi Xu - Naperville IL
Albert Khilevich - Glenview IL
David Zembower - Oak Park IL
John D. Rizzo - Downers Grove IL
Shuyuan Liao - Glen Ellyn IL
Aye Mar - Chicago IL
Lin Lin - Chicago IL
Vilayphone Vilaychack - Elgin IL
Darko Brankovic - Bolingbrook IL
Sergey Dzekhster - Chicago IL
Jinjun Liu - Naperville IL

Assignee:

Sarawak MediChem Pharmaceuticals, Inc. - Lemont IL

International Classification:

C07D49322

US Classification:

549277

Abstract:

A method of preparing (+)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. According to the disclosed method, chromene 4 intermediate was subjected to a chlorotitanium-mediated aldol reaction with acetaldehyde to selectively produce (. +-. )-8a. Separation and enzyme-mediated resolution of (. +-. )-8a produced (+)-8a. Cyclization of (+)-8a under neutral Mitsunobu conditions followed by Luche reduction of (. +-. )-7 produced (+)-calanolide A in high yield and enantiomeric purity. The method of the invention has been extended to produce potent antiviral calanolide A analogues.

US Patent:

58693246, Feb 9, 1999

Filed:

Sep 8, 1997

Appl. No.:

8/933619

Inventors:

Michael T. Flavin - Darien IL
Ze-Qi Xu - Naperville IL
John D. Rizzo - Downers Grove IL
Alla Kucherenko - Naperville IL
Albert Khilevich - Glenview IL
Abram Kivovich Sheinkman - Naperville IL
Vilayphone Vilaychack - Elgin IL
Lin Lin - Chicago IL
Wei Chen - Naperville IL
William A. Boulanger - Schenectady NY

Assignee:

Sarawak MediChem Pharmaceuticals, Inc. - Lemont IL

International Classification:

C12P 4100

US Classification:

435280

Abstract:

A method of preparing (. +-. )-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. Useful intermediates for preparing (. +-. )-calanolide A and its derivatives are also provided. According to the disclosed method, chromene 4 intermediate was reacted with acetaldehyde diethyl acetal or paraldehyde in the presence of an acid catalyst with heating, or a two-step reaction including an aldol reaction with acetaldehyde and cyclization either under acidic conditions or neutral Mitsunobu conditions, to produce chromanone 7. Reduction of chromanone 7 with sodium borohydride, in the presence of cerium trichloride, produced (. +-. )-calanolide A. A method for resolving (. +-. )-calanolide A into its optically active forms by a chiral HPLC system or by enzymatic acylation and hydrolysis is also disclosed. Finally, a method for treating or preventing viral infections using (. +-.