Lin Liu

US Patent:

20210261625, Aug 26, 2021

Filed:

Jan 29, 2021

Appl. No.:

17/162356

Inventors:

- Cambridge MA, US
Xiaoying Jin - Cambridge MA, US
Lin Liu - Cambridge MA, US
Catherine O'Riordan - Cambridge MA, US
Jennifer Sullivan - Cambridge MA, US

International Classification:

C07K 14/005
C12N 15/86

Abstract:

Provided herein are modified adeno-associated viral (AAV) capsid proteins, compositions (e.g., rAAV) comprising the capsid proteins, and nucleic acids encoding the capsid proteins. The AAV capsids provided herein confer retinal cell tropism and/or corneal cell tropism, and mediate improved transduction efficiency in clinically relevant ocular cell types such as photoreceptors and/or corneal endothelial cells. Also provided are nucleic acids encoding the capsid proteins, and AAV particles comprising the capsid proteins.

US Patent:

20150366212, Dec 24, 2015

Filed:

Jun 24, 2015

Appl. No.:

14/749122

Inventors:

- Washington DC, US
Lin S. Liu - Blue Bell PA, US

International Classification:

A01N 55/08
C07F 5/02

Abstract:

Compounds having one of the following formulae:wherein Rand Rare alkyl or aryl and Rand Rmay be the same or different,wherein Ris alkyl o aryl, orwherein alkyl is a liner or branched, saturated or unsaturated alkyl having C1-20 and wherein aryl is an aromatic ring having C1-15. Also methods of using the compounds, including method of inhibiting and ethylene response in a plant.