Lin Dee Liu

US Patent:

6773723, Aug 10, 2004

Filed:

Aug 30, 2000

Appl. No.:

09/652604

Inventors:

Robert C. Spiro - Half Moon Bay CA
Lin Shu Liu - Sunnyvale CA

Assignee:

Depuy Acromed, Inc. - Mountain View CA

International Classification:

A61K 31715

US Classification:

424488, 424 783, 424486, 4283166, 514 1, 514 2, 514 23, 530402

Abstract:

Disclosed are bilayer matrices of a polysaccharide such as collagen (COL) and another polysaccharide such as hyaluronic acid (HA) with various COL/HA ratios. Each layer has a porous structure. These materials are useful for tissue regeneration, particularly when used with orthopedic implants and drug delivery.

US Patent:

6896904, May 24, 2005

Filed:

Jun 14, 2004

Appl. No.:

10/868041

Inventors:

Robert C. Spiro - Half Moon Bay CA, US
Lin Shu Liu - Sunnyvale CA, US

Assignee:

Depuy Spine, Inc. - Raynham MA

International Classification:

A61K031/715
A61K038/16
A61K009/70
C08H001/02
B32B005/32

US Classification:

424488, 424 783, 424486, 4283166, 514 1, 514 2, 514 23, 530402

Abstract:

Disclosed are bilayer matrices of a polysaccharide such as collagen (COL) and another polysaccharide such as hyaluronic acid (HA) with various COL/HA ratios. Each layer has a porous structure. These materials are useful for tissue regeneration, particularly when used with orthopedic implants and drug delivery.

US Patent:

6936276, Aug 30, 2005

Filed:

Jun 14, 2004

Appl. No.:

10/868046

Inventors:

Robert C. Spiro - Half Moon Bay CA, US
Lin Shu Liu - Sunnyvale CA, US

Assignee:

Depuy Acromed, Inc. - Raynham MA

International Classification:

A61K031/715
A61K038/16
A61K009/70
C08H001/02
B32B005/32

US Classification:

424488, 424 783, 424486, 4283166, 514 1, 514 2, 514 23, 530402

Abstract:

Disclosed are bilayer matrices of a polysaccharide such as collagen (COL) and another polysaccharide such as hyaluronic acid (HA) with various COL/HA ratios. Each layer has a porous structure. These materials are useful for tissue regeneration, particularly when used with orthopedic implants and drug delivery.

US Patent:

6939562, Sep 6, 2005

Filed:

Jun 14, 2004

Appl. No.:

10/868043

Inventors:

Robert C. Spiro - Half Moon Bay CA, US
Lin Shu Liu - Sunnyvale CA, US

Assignee:

Depuy Acromed, Inc. - Raynham MA

International Classification:

A61K031/715
A61K038/16
A61K009/70
C08H001/02
B32B005/32

US Classification:

424488, 424 783, 424486, 4283166, 514 1, 514 2, 514 23, 530402

Abstract:

Disclosed are bilayer matrices of a polysaccharide such as collagen (COL) and another polysaccharide such as hyaluronic acid (HA) with various COL/HA ratios. Each layer has a porous structure. These materials are useful for tissue regeneration, particularly when used with orthopedic implants and drug delivery.

US Patent:

6953784, Oct 11, 2005

Filed:

Oct 3, 2003

Appl. No.:

10/679110

Inventors:

Andrea Y. Thompson - Mountain View CA, US
Lin Shu Liu - San Luis Obispo CA, US
Robert C. Spiro - Half Moon Bay CA, US

Assignee:

Depuy Spine, Inc. - Raynham MA

International Classification:

A61K031/738
C08B037/00

US Classification:

514 44, 514 54, 514 56, 536 21, 536 53, 536112

Abstract:

A carrier and a method for preparing it are provided for use in the delivery of therapeutic agents. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to form aldehyde groups. The aldehyde groups are reacted to form covalent oxime linkages with a second polysaccharide and each of the first and second polysaccharide is selected from the group consisting of hyaluronic acid, dextran, dextran sulfate, chondroitin sulfate, dermatan sulfate, keratan sulfate, heparan, heparan sulfate and alginate.

US Patent:

20030012765, Jan 16, 2003

Filed:

Sep 17, 2001

Appl. No.:

09/954855

Inventors:

Andrea Thompson - Mountain View CA, US
Lin Liu - San Luis Obispo CA, US
Robert Spiro - Half Moon Bay CA, US

International Classification:

A61K048/00
A61K038/22
A61K038/19
A61K031/737
A61K031/728

US Classification:

424/085100, 514/012000, 514/044000, 514/054000, 424/093700

Abstract:

A carrier and a method for preparing it are provided for use in the delivery of therapeutic agents. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to form aldehyde groups. The aldehyde groups are reacted to form covalent oxime linkages with a second polysaccharide and each of the first and second polysaccharide is selected from the group consisting of hyaluronic acid, dextran, dextran sulfate, chondroitin sulfate, dermatan sulfate, keratan sulfate, heparan, heparan sulfate and alginate.

US Patent:

20170229169, Aug 10, 2017

Filed:

Apr 24, 2017

Appl. No.:

15/495574

Inventors:

- Santa Clara CA, US
Hagop Nazarian - San Jose CA, US
Lin Shih Liu - Fremont CA, US

International Classification:

G11C 13/00
G11C 14/00

Abstract:

Providing for improved sensing of non-volatile resistive memory to achieve higher sensing margins, is described herein. The sensing can leverage current-voltage characteristics of a volatile selector device within the resistive memory. A disclosed sensing process can comprise activating the selector device with an activation voltage, and then lowering the activation voltage to a holding voltage at which the selector device deactivates for an off-state memory cell, but remains active for an on-state memory cell. Accordingly, very high on-off ratio characteristics of the selector device can be employed for sensing the resistive memory, providing sensing margins not previously achievable for non-volatile memory.

US Patent:

20160005461, Jan 7, 2016

Filed:

Jun 30, 2015

Appl. No.:

14/755998

Inventors:

- Santa Clara CA, US
Hagop Nazarian - San Jose CA, US
Lin Shih Liu - Fremont CA, US

International Classification:

G11C 13/00
G11C 14/00

Abstract:

Providing for improved sensing of non-volatile resistive memory to achieve higher sensing margins, is described herein. The sensing can leverage current-voltage characteristics of a volatile selector device within the resistive memory. A disclosed sensing process can comprise activating the selector device with an activation voltage, and then lowering the activation voltage to a holding voltage at which the selector device deactivates for an off-state memory cell, but remains active for an on-state memory cell. Accordingly, very high on-off ratio characteristics of the selector device can be employed for sensing the resistive memory, providing sensing margins not previously achievable for non-volatile memory.