Lin E Tang

US Patent:

20200080141, Mar 12, 2020

Filed:

Nov 19, 2019

Appl. No.:

16/689018

Inventors:

- George Town, KY
Shengrong LIN - Fremont CA, US
Lin Fung TANG - San Francisco CA, US

International Classification:

C12Q 1/6865
C12Q 1/6806
C12Q 1/6874
C12Q 1/6853

Abstract:

In some aspects, the present disclosure provides methods for enriching amplicons, or amplification products, comprising a concatemer of at least two or more copies of a target polynucleotide. In some embodiments, a method comprises sequencing the amplicons comprising at least two or more copies of a target polynucleotide. In some embodiments, the target polynucleotides comprise sequences resulting from chromosome rearrangement, including but not limited to point mutations, single nucleotide polymorphisms, insertions, deletions, and translocations including fusion genes. In some aspects, the present disclosure provides compositions and reaction mixtures useful in the described methods.

US Patent:

20200010883, Jan 9, 2020

Filed:

Jun 7, 2019

Appl. No.:

16/434941

Inventors:

- George Town KY, US
Shengrong LIN - Fremont CA, US
Lin Fung TANG - San Francisco CA, US

International Classification:

C12Q 1/6865
C12Q 1/6853
C12Q 1/6806
C12Q 1/6874

Abstract:

In some aspects, the present disclosure provides methods for enriching amplicons, or amplification products, comprising a concatemer of at least two or more copies of a target polynucleotide. In some embodiments, a method comprises sequencing the amplicons comprising at least two or more copies of a target polynucleotide. In some embodiments, the target polynucleotides comprise sequences resulting from chromosome rearrangement, including but not limited to point mutations, single nucleotide polymorphisms, insertions, deletions, and translocations including fusion genes. In some aspects, the present disclosure provides compositions and reaction mixtures useful in the described methods.