Lin Zhang

US Patent:

20120015049, Jan 19, 2012

Filed:

Jan 14, 2010

Appl. No.:

13/144685

Inventors:

Lin Zhang - Philadelphia PA, US

International Classification:

A61K 31/7105
C12Q 1/68
C07H 21/00
A61P 35/00
C40B 40/06
A61K 31/713
A61K 33/24
C40B 30/00
C40B 30/04

US Classification:

424649, 506 7, 435 611, 435 613, 536 245, 506 9, 506 16, 536 243, 514 44 A, 514 44 R

Abstract:

This invention provides compositions and methods for predicting and improving a chemotherapy response to treat an ovarian cancer. In one embodiment, the invention provides compositions and methods for detecting the expression level of Let-7i microRNA to predict a chemotherapy response. In another embodiment, the invention provides compositions and methods for enhancing the expression level of Let-7i microRNA to improve a chemotherapy response.

US Patent:

63331527, Dec 25, 2001

Filed:

May 20, 1998

Appl. No.:

9/081646

Inventors:

Bert Vogelstein - Baltimore MD
Kenneth W. Kinzler - BelAir MD
Lin Zhang - Baltimore MD
Wei Zhou - Baltimore MD

Assignee:

The JohnsHopkins University - Baltimore MD

International Classification:

C12Q 168
C12P 1934
C07H 2102
C07H 2104

US Classification:

435 6

Abstract:

As a step towards understanding the complex differences between normal and cancer cells, gene expression patterns were examined in gastrointestinal tumors. More than 300,000 transcripts derived from at least 45,000 different genes were analyzed. Although extensive similarity was noted between the expression profiles, more than 500 transcripts that were expressed at significantly different levels in normal and neoplastic cells were identified. These data provide insights into the extent of expression differences underlying malignancy and reveal genes that are useful as diagnostic or prognostic markers.

US Patent:

63068869, Oct 23, 2001

Filed:

Jun 15, 1998

Appl. No.:

9/094944

Inventors:

Michael Blaise Maurin - Wilmington DE
Philip Ma - Chadds Ford PA
David John Meloni - Newark DE
Jaan A. Pesti - Wilmington DE
Lucius Thomas Rossano - Newark DE
Randall K. Ward - Wilmington DE
Jianguo Yin - Hockessin DE
Lin Hua Zhang - New Fairfield CT
Goss S. Kauffman - Bear DE

Assignee:

DuPont Pharmaceuticals Company - Wilmington DE

International Classification:

A61K 3112
C07D26104
A61P 702

US Classification:

514378

Abstract:

The potent platelet glycoprotein IIb/IIIa antagonist, roxifiban, is produced in crystalline form. Crystalline roxifiban exists in two polymorphic forms, designated Form 1 and Form 2. These polymorphic forms are characterized by x-ray powder diffraction and solid-state carbon NMR. Pharmaceutical compositions and methods for the treatment or prevention of diseases mediated by platelet aggregation are described.

US Patent:

20150323819, Nov 12, 2015

Filed:

Mar 6, 2014

Appl. No.:

14/199423

Inventors:

Juejun Hu - Newark DE, US
Hongtao Lin - Newark DE, US
Okechukwu Ogbuu - Newark DE, US
Jifeng Liu - Hanover NH, US
Lin Zhang - Cambridge MA, US
Jurgen Michel - Cambridge MA, US

Assignee:

UNIVERSITY OF DELAWARE - NEWARK DE

International Classification:

G02F 1/035
G02F 1/00

Abstract:

Electro-optic modulators are disclosed. An electro-optic modulator includes an optical ring resonator, an optical waveguide, and a cavity of electro-optic material. The waveguide has a first portion positioned adjacent the resonator to create a first coupling region and a second portion positioned adjacent the resonator to create a second coupling region. The cavity of electro-optic material is embedded within the waveguide between the first portion and the second portion. A method of optical modulation includes the steps of receiving light into an optical waveguide, coupling a portion of the light from the waveguide into an optical ring resonator at a first coupling region between the waveguide and the resonator, transmitting the light remaining in the waveguide into a cavity of electro-optic material embedded within the waveguide, and transmitting the light from the cavity to a second coupling region between the waveguide and the resonator.

US Patent:

20140291168, Oct 2, 2014

Filed:

Nov 8, 2012

Appl. No.:

14/357095

Inventors:

- Wilmington DE, US
Lin Zhang - Wilmington DE, US

Assignee:

Nanoselect, Inc. - Wilmington DE

International Classification:

G01N 27/30

US Classification:

2057785, 2057875, 2057865, 205782, 2057855, 205781, 204412, 977957, 977746

Abstract:

A chronoamperometric method and device to determine concentration of an electrochemically active species in a fluid and pH of the fluid. A plurality of sets of calibration relationships may be determined for a sensor in an aqueous solution, the sensor having one or more working electrodes and one or more reference electrodes. A first plurality of potentials may be applied across the working and reference electrodes of the sensor in solution, and a first plurality of currents and current differences obtained as a function of the applied first plurality of potentials. Concentration of an electrochemically active species may then be determined as a function of the obtained first plurality of currents and current differences using the plural sets of calibration relationships, and pH of the solution may be determined as a function of the obtained first plurality of currents and current differences using the plural sets of calibration relationships.