Lin C Zhang

US Patent:

20120015049, Jan 19, 2012

Filed:

Jan 14, 2010

Appl. No.:

13/144685

Inventors:

Lin Zhang - Philadelphia PA, US

International Classification:

A61K 31/7105
C12Q 1/68
C07H 21/00
A61P 35/00
C40B 40/06
A61K 31/713
A61K 33/24
C40B 30/00
C40B 30/04

US Classification:

424649, 506 7, 435 611, 435 613, 536 245, 506 9, 506 16, 536 243, 514 44 A, 514 44 R

Abstract:

This invention provides compositions and methods for predicting and improving a chemotherapy response to treat an ovarian cancer. In one embodiment, the invention provides compositions and methods for detecting the expression level of Let-7i microRNA to predict a chemotherapy response. In another embodiment, the invention provides compositions and methods for enhancing the expression level of Let-7i microRNA to improve a chemotherapy response.

US Patent:

63068869, Oct 23, 2001

Filed:

Jun 15, 1998

Appl. No.:

9/094944

Inventors:

Michael Blaise Maurin - Wilmington DE
Philip Ma - Chadds Ford PA
David John Meloni - Newark DE
Jaan A. Pesti - Wilmington DE
Lucius Thomas Rossano - Newark DE
Randall K. Ward - Wilmington DE
Jianguo Yin - Hockessin DE
Lin Hua Zhang - New Fairfield CT
Goss S. Kauffman - Bear DE

Assignee:

DuPont Pharmaceuticals Company - Wilmington DE

International Classification:

A61K 3112
C07D26104
A61P 702

US Classification:

514378

Abstract:

The potent platelet glycoprotein IIb/IIIa antagonist, roxifiban, is produced in crystalline form. Crystalline roxifiban exists in two polymorphic forms, designated Form 1 and Form 2. These polymorphic forms are characterized by x-ray powder diffraction and solid-state carbon NMR. Pharmaceutical compositions and methods for the treatment or prevention of diseases mediated by platelet aggregation are described.

US Patent:

20150323819, Nov 12, 2015

Filed:

Mar 6, 2014

Appl. No.:

14/199423

Inventors:

Juejun Hu - Newark DE, US
Hongtao Lin - Newark DE, US
Okechukwu Ogbuu - Newark DE, US
Jifeng Liu - Hanover NH, US
Lin Zhang - Cambridge MA, US
Jurgen Michel - Cambridge MA, US

Assignee:

UNIVERSITY OF DELAWARE - NEWARK DE

International Classification:

G02F 1/035
G02F 1/00

Abstract:

Electro-optic modulators are disclosed. An electro-optic modulator includes an optical ring resonator, an optical waveguide, and a cavity of electro-optic material. The waveguide has a first portion positioned adjacent the resonator to create a first coupling region and a second portion positioned adjacent the resonator to create a second coupling region. The cavity of electro-optic material is embedded within the waveguide between the first portion and the second portion. A method of optical modulation includes the steps of receiving light into an optical waveguide, coupling a portion of the light from the waveguide into an optical ring resonator at a first coupling region between the waveguide and the resonator, transmitting the light remaining in the waveguide into a cavity of electro-optic material embedded within the waveguide, and transmitting the light from the cavity to a second coupling region between the waveguide and the resonator.

US Patent:

20140291168, Oct 2, 2014

Filed:

Nov 8, 2012

Appl. No.:

14/357095

Inventors:

- Wilmington DE, US
Lin Zhang - Wilmington DE, US

Assignee:

Nanoselect, Inc. - Wilmington DE

International Classification:

G01N 27/30

US Classification:

2057785, 2057875, 2057865, 205782, 2057855, 205781, 204412, 977957, 977746

Abstract:

A chronoamperometric method and device to determine concentration of an electrochemically active species in a fluid and pH of the fluid. A plurality of sets of calibration relationships may be determined for a sensor in an aqueous solution, the sensor having one or more working electrodes and one or more reference electrodes. A first plurality of potentials may be applied across the working and reference electrodes of the sensor in solution, and a first plurality of currents and current differences obtained as a function of the applied first plurality of potentials. Concentration of an electrochemically active species may then be determined as a function of the obtained first plurality of currents and current differences using the plural sets of calibration relationships, and pH of the solution may be determined as a function of the obtained first plurality of currents and current differences using the plural sets of calibration relationships.