Lin Z Zhang

US Patent:

20200121281, Apr 23, 2020

Filed:

Oct 21, 2019

Appl. No.:

16/658237

Inventors:

- Cambridge MA, US
Lin Zhang - Cambridge MA, US

International Classification:

A61B 8/00
G01N 29/24

Abstract:

An ultrasound patch may conform to a curved surface of a large, curvilinear part of a human body, and may capture ultrasound images of underlying tissue for detection of disease. The patch may comprise a flexible, elastomeric substrate, in which phased arrays of piezoelectric ultrasound transducers are embedded. The phased arrays may steer ultrasound beams through a wide angle to image a large volume of tissue. Mechanical deformation of the flexible substrate as it conforms to a curvilinear body part may change the relative 3D positions of the phase arrays. However, localization may be performed to detect these 3D positions. Data captured by the phased arrays may be processed, to create an ultrasound image of the underlying tissue. A semi-flexible, intermediate layer may partially encapsulate each phased array, to distribute stress at an interface between the rigid phased array and more flexible substrate.

US Patent:

20190017922, Jan 17, 2019

Filed:

Jul 16, 2018

Appl. No.:

16/036286

Inventors:

- Tewksbury MA, US
Eric A. MARTIN - Medford MA, US
David PEREZ - Milford MA, US
Michael HARGREAVES - Burlington MA, US
Lin ZHANG - Andover MA, US
Xiaofeng TAN - Acton MA, US

International Classification:

G01N 21/01
G01N 21/71

Abstract:

In the operation of analytical devices, and particularly laser induced breakdown spectroscopy (LIBS) devices, a number of advantages may be obtained by the use of complementary safety mechanisms, such as those that govern the operation or firing of a laser. Such complementary safety mechanisms, compared to the individual safety mechanisms acting alone, prevent operation of the laser under a greater number of unsafe circumstances (even if one or more detected conditions are safe, based on not activating the associated safety mechanism) and permits operation under a greater number of safe circumstances (even if one or more detected conditions are unsafe, based on activating the associated safety mechanism).

US Patent:

20150167020, Jun 18, 2015

Filed:

Jun 20, 2013

Appl. No.:

14/409283

Inventors:

- Slough, Berkshire, GB
- New York NY, US
Michael J. Agostino - Andover MA, US
Mark Moffat - St. Louis MO, US
Lin Zhang - Boxford MA, US
Baohong Zhang - Madison CT, US

Assignee:

LONZA BIOLOGICS PLC - Slough, Berkshire
PFIZER INC. - New York NY

International Classification:

C12N 15/90
C12P 21/00
C07K 16/00

Abstract:

The present invention relates to stable and high-producing site-specific integration (SSI) host cells, e.g. Chinese hamster ovary (CHO)-derived host cells, methods to produce and to use them.