Lin M Zhang

US Patent:

6383743, May 7, 2002

Filed:

Jun 30, 1998

Appl. No.:

09/107228

Inventors:

Kenneth W. Kinzler - Bel Air MD
Bert Vogelstein - Baltimore MD
Victor E. Velculescu - Baltimore MD
Lin Zhang - Baltimore MD

Assignee:

The John Hopkins University School of Medicine - Baltimore MD

International Classification:

C12Q 168

US Classification:

435 6, 435196, 536 231, 702 19

Abstract:

Serial analysis of gene expression, SAGE, a method for the rapid quantitative and qualitative analysis of transcripts is provided. Short defined sequence tags corresponding to expressed genes are isolated and analyzed. Sequencing of over 1,000 defined tags in a short period of time (e. g. , hours) reveals a gene expression pattern characteristic of the function of a cell or tissue. Moreover, SAGE is useful as a gene discovery tool for the identification and isolation of novel sequence tags corresponding to novel transcripts and genes.

US Patent:

6746845, Jun 8, 2004

Filed:

Mar 14, 2002

Appl. No.:

10/096596

Inventors:

Kenneth W. Kinzler - Bel Air MD
Bert Vogelstein - Baltimore MD
Victor E. Velculescu - Baltimore MD
Lin Zhang - Baltimore MD

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

C12Q 168

US Classification:

435 6, 435 911, 435 915, 536 231, 536 242

Abstract:

Serial analysis of gene expression, SAGE, a method for the rapid quantitative and qualitative analysis of transcripts is provided. Short defined sequence tags corresponding to expressed genes are isolated and analyzed. Sequencing of over 1,000 defined tags in a short period of time (e. g. , hours) reveals a gene expression pattern characteristic of the function of a cell or tissue. Moreover, SAGE is useful as a gene discovery tool for the identification and isolation of novel sequence tags corresponding to novel transcripts and genes.

US Patent:

63331527, Dec 25, 2001

Filed:

May 20, 1998

Appl. No.:

9/081646

Inventors:

Bert Vogelstein - Baltimore MD
Kenneth W. Kinzler - BelAir MD
Lin Zhang - Baltimore MD
Wei Zhou - Baltimore MD

Assignee:

The JohnsHopkins University - Baltimore MD

International Classification:

C12Q 168
C12P 1934
C07H 2102
C07H 2104

US Classification:

435 6

Abstract:

As a step towards understanding the complex differences between normal and cancer cells, gene expression patterns were examined in gastrointestinal tumors. More than 300,000 transcripts derived from at least 45,000 different genes were analyzed. Although extensive similarity was noted between the expression profiles, more than 500 transcripts that were expressed at significantly different levels in normal and neoplastic cells were identified. These data provide insights into the extent of expression differences underlying malignancy and reveal genes that are useful as diagnostic or prognostic markers.

US Patent:

56959370, Dec 9, 1997

Filed:

Sep 12, 1995

Appl. No.:

8/527154

Inventors:

Kenneth W. Kinzler - Bel Air MD
Bert Vogelstein - Baltimore MD
Victor E. Velculescu - Baltimore MD
Lin Zhang - Baltimore MD

Assignee:

The Johns Hopkins University School of Medicine - Baltimore MD

International Classification:

C12Q 0168
C12P 1934
C12N 1500
C07H 2100

US Classification:

435 6

Abstract:

Serial analysis of gene expression, SAGE, a method for the rapid quantitative and qualitative analysis of transcripts is provided. Short defined sequence tags corresponding to expressed genes are isolated and analyzed. Sequencing of over 1,000 defined tags in a short period of time (e. g. , hours) reveals a gene expression pattern characteristic of the function of a cell or tissue. Moreover, SAGE is useful as a gene discovery tool for the identification and isolation of novel sequence tags corresponding to novel transcripts and genes.

US Patent:

58663304, Feb 2, 1999

Filed:

Oct 18, 1995

Appl. No.:

8/544861

Inventors:

Kenneth W. Kinzler - Bel Air MD
Bert Vogelstein - Baltimore MD
Victor E. Velculescu - Baltimore MD
Lin Zhang - Baltimore MD

Assignee:

The Johns Hopkins University School of Medicine - Baltimore MD

International Classification:

C12Q 168
C12P 1934
C07H 2102
C07H 2104

US Classification:

435 6

Abstract:

Serial analysis of gene expression, SAGE, a method for the rapid quantitative and qualitative analysis of transcripts is provided. Short defined sequence tags corresponding to expressed genes are isolated and analyzed. Sequencing of over 1,000 defined tags in a short period of time (e. g. , hours) reveals a gene expression pattern characteristic of the function of a cell or tissue. Moreover, SAGE is useful as a gene discovery tool for the identification and isolation of novel sequence tags corresponding to novel transcripts and genes.