Linas R Stasaitis

US Patent:

6342079, Jan 29, 2002

Filed:

Jan 27, 2000

Appl. No.:

09/491717

Inventors:

Yuh-Guo Pan - Stamford CT
Linas R. Stasaitis - Fairfield CT

Assignee:

Bristol-Myers Squibb Company - New York NY

International Classification:

A61K 713

US Classification:

8410, 8416, 564305, 564397, 564418, 564419

Abstract:

1-(2,5-Diaminophenyl)ethanol useful as a primary intermediate for the oxidative dyeing of hair.

US Patent:

6540793, Apr 1, 2003

Filed:

Dec 7, 2000

Appl. No.:

09/732485

Inventors:

Linas R. Stasaitis - Fairfield CT
Yuh-Guo Pan - Stamford CT

Assignee:

Clairol Incorporated - Stamford CT

International Classification:

A61K 713

US Classification:

8409, 8412, 8421, 8423, 564307, 564431, 564433, 564445, 564443, 549358, 549377

Abstract:

Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): wherein R is selected from the group consisting of C to C alkyl and hydroxyethyl; R is selected from the group consisting of a hydrogen, hydroxy, nitro, halogen, C to C alkyl or haloalkyl, C to C alkoxy or cycloalkoxy, C to C hydroxyalkyl and C to C hydroxyalkoxy; Ar is an aromatic group, preferably an aromatic group selected from the group consisting of a furyl, thienyl, pyridyl, phenyl, 2,3-dihydro-benzo[1,4]dioxin-5 or -6-yl or benzo[1,3]dioxol-4 or -5-yl group; and y=1 to 3.

US Patent:

54203627, May 30, 1995

Filed:

Oct 8, 1993

Appl. No.:

8/133352

Inventors:

Linas Stasaitis - Fairfield CT
Alexander Chan - Mineola NY

Assignee:

Clairol, Inc. - New York NY

International Classification:

C07C 3914

US Classification:

568736

Abstract:

4-Halo-1-naphthol is reacted with a secondary amine and formaldehyde to produce a reaction mixture containing a Mannich base which is hydrogenated to produce 2-methyl-1-naphthol. Advantageously, the procedure can be carried out in one pot.

US Patent:

60744383, Jun 13, 2000

Filed:

Mar 3, 1998

Appl. No.:

9/033632

Inventors:

Yuh-Guo Pan - Stamford CT
Linas R. Stasaitis - Fairfield CT

Assignee:

Bristol-Myers Squibb Co. - New York NY

International Classification:

A61K 713

US Classification:

8409

Abstract:

The invention provides compositions and methods for the oxidative coloring of human hair. The compositions of the invention contain as a primary intermediate at least one aminophenol of the formulas: ##STR1## or a cosmetically acceptable salt thereof, and at least one pyrazolone coupler of the formulas: ##STR2## or a cosmetically acceptable salt thereof. The compositions may also contain one or more other primary intermediates and conventional coupling compounds, in addition to an oxidizing agent and other components typically used in oxidative hair dye preparations.

US Patent:

54866197, Jan 23, 1996

Filed:

Apr 29, 1994

Appl. No.:

8/235763

Inventors:

Gottfried Wenke - Woodbridge CT
Yuh-Guo Pan - Stamford CT
Linas Stasaitis - Fairfield CT

Assignee:

Clairol, Inc. - New York NY

International Classification:

C07D20908

US Classification:

548508

Abstract:

A method of producing and isolating 5,6-diacetoxyindole (DAI) in a single reaction vessel comprising the following steps: (a) preparing a first solution comprising dopa, water and a solubilizing agent selected from the group consisting of an acid having a pk. sub. a value equal to or less than 4 and a first base having a pk. sub. b value equal to or greater than 10; (b) preparing a second solution comprising an oxidant, a buffer and water; (c) mixing the first and second solutions to form a combined solution which is rendered oxygen-free and has a pH of from about 6 to about 9; (d) stirring the combined solution in an inert atmosphere until 5,6-dihydroxyindole (DHI) is substantially completely formed; (e) adding a derivatizing agent and a second base to the combined solution to form a final solution; (f) stirring the final solution until the DHI is substantially fully consumed; (g) cooling the final solution to precipitate DAI; (h) isolating the precipitated DAI.

US Patent:

62003534, Mar 13, 2001

Filed:

Feb 1, 2000

Appl. No.:

9/495582

Inventors:

Linas R. Stasaitis - Fairfield CT
Yuh-Guo Pan - Stamford CT

Assignee:

Bristol Myers Squibb Company - New York NY

International Classification:

A61K 713
C07D20730
C07D30734
C07D33304

US Classification:

8409

Abstract:

Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula at least one coupler comprising a compound of the formula: ##STR1## wherein R is selected from the group consisting of C. sub. 1 to C. sub. 2 alkyl and hydroxyethyl, R. sup. 1 is selected from the group consisting of hydrogen, chlorine, bromine, C. sub. 1 to C. sub. 3 alkyl, C. sub. 1 to C. sub. 3 alkoxy, C. sub. 1 to C. sub. 3 hydroxyalkyl and C. sub. 1 to C. sub. 3 hydroxyalkoxy, and X is O, S or NH.

US Patent:

56706987, Sep 23, 1997

Filed:

Aug 19, 1996

Appl. No.:

8/699259

Inventors:

Yuh-Guo Pan - Stamford CT
Linas Stasaitis - Fairfield CT
James Anderson - Bethel CT

Assignee:

Bristol-Myers Squibb Company - New York NY

International Classification:

C07C 6900

US Classification:

560139

Abstract:

A one pot process is provided in which a Mannich base of the formula 5 is reacted with acetic anhydride to produce a diacetate derivative. Without any intermediate isolation, the derivative is hydrogenated to produce a reaction mixture containing 1-acetoxy-2-methylnaphthalene which is readily precipitated from the reaction mixture by addition of water. ##STR1##.

US Patent:

56721803, Sep 30, 1997

Filed:

Apr 15, 1996

Appl. No.:

8/632224

Inventors:

Yuh-Guo Pan - Stamford CT
Linas R. Stasaitis - Fairfield CT
John D. O'Donoghue - Rye Brook NY

Assignee:

Clairol Incorporated - New York NY

International Classification:

A61K 713

US Classification:

8408

Abstract:

Compounds of Formula II ##STR1## wherein R. sub. 3 is --COOCH. sub. 3, --COCH. sub. 3 or --COCH. sub. 2 CH. sub. 3 and R. sub. 4 is hydrogen or R. sub. 3 is hydrogen and R. sub. 4 is --OCH. sub. 3, --OCH. sub. 2 CH. sub. 3, --OCH. sub. 2 CH. sub. 2 OH or --OCH. sub. 2 CH. sub. 2 OCH. sub. 3 are storage stable and can be used in oxidative hairdye systems in place of the storage unstable 2-methyl-1-naphthol. Advantageously, it has been found to produce the same colors as 2-methyl-1-naphthol.