Linda M Weigel

US Patent:

20050009044, Jan 13, 2005

Filed:

Mar 10, 2004

Appl. No.:

10/798827

Inventors:

Linda Weigel - Decatur GA, US
Fred Tenover - Atlanta GA, US

International Classification:

C12Q001/68
C07H021/04

US Classification:

435006000, 536023700, 536024100

Abstract:

Oligonucleotide probes for detecting species. Unique gyrA coding regions permit the development of probes specific for eight different species: and The invention thereby provides methods for the species-specific identification of these in a sample, and detection and diagnosis of infection in a subject. Further, nucleic acids are provided for determining quinolone-resistant status of these

US Patent:

20080199877, Aug 21, 2008

Filed:

Apr 17, 2008

Appl. No.:

12/105243

Inventors:

Linda M. Weigel - Decatur GA, US
Fred C. Tenover - Atlanta GA, US

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

Oligonucleotide probes for detecting Enterobacteriaceae species. Unique gyrA coding regions permit the development of probes specific for eight different species: and . The invention thereby provides methods for the species-specific identification of these Enterobacteriaceae in a sample, and detection and diagnosis of Enterobacteriaceae infection in a subject. Further, nucleic acids are provided for determining quinolone-resistant status of these Enterobacteriaceae.

US Patent:

6706475, Mar 16, 2004

Filed:

Jan 16, 2001

Appl. No.:

09/647563

Inventors:

Linda M. Weigel - Decatur GA
Fred C. Tenover - Atlanta GA

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

C12Q 168

US Classification:

435 6, 435 911, 436 94, 536 231, 536 243, 536 2433

Abstract:

Oligonucleotide probes for detecting Enterobacteriaceae species. Unique gyrA coding regions permit the development of probes specific for eight different species: , and. The invention thereby provides methods for the species-specific identification of these Enterobacteriaceae in a sample, and detection and diagnosis of Enterobacteriaceae infection in a subject. Further, nucleic acids are provided for determining quinolone-resistant status of these Enterobacteriaceae.

US Patent:

20190153413, May 23, 2019

Filed:

Jan 30, 2019

Appl. No.:

16/262258

Inventors:

- Washington DC, US
Linda Weigel - Decatur GA, US
Bernard Quigley - Atlanta GA, US
David R. Hodge - Washington DC, US

Assignee:

The Government of the United States of America, as represented by the Secretary of Homeland Security - Washington DC

International Classification:

C12N 9/24
A01N 47/44
A61K 38/47
C12Q 1/689
A61K 38/12

Abstract:

Novel lysin proteins have been identified and characterized. Methods to detect the presence or absence of bacteria in a sample, methods for lysing bacteria, and methods for decontaminating or disinfecting areas contaminated with bacteria that utilize these lysin proteins have also been developed.

US Patent:

20170240876, Aug 24, 2017

Filed:

Feb 18, 2016

Appl. No.:

15/047319

Inventors:

- Washington DC, US
Linda Weigel - Decatur GA, US
Bernard Quigley - Atlanta GA, US
David R. Hodge - Washington DC, US

Assignee:

The Government of the United States of America, as represented by the Secretary of Homeland Securit - Washington DC

International Classification:

C12N 9/24
A01N 47/44
A61K 38/12
C12Q 1/68
A61K 38/47

Abstract:

Disclosed herein are the identification, cloning, and optimizing the lytic activity of one or more novel lysin proteins, a method of selecting a lysin agent for use in molecular diagnostic testing that includes analyzing genome databases for and near neighbors, selecting candidate genes encoding potential lytic enzymes based on conserved amino acid motifs as determined in peptidoglycan hydrolases, cloning the candidate genes in expression vector, isolating proteins thereof, and testing for lytic activity against , and selecting an optimum gene of the candidate genes for optimizing lysis conditions.