Ling Chen

US Patent:

6506435, Jan 14, 2003

Filed:

Nov 3, 1999

Appl. No.:

09/432945

Inventors:

Brock Lundberg - St. Paul MN
Lin Gu - St. Paul MN
Rongsheng Roger Ruan - Arden Hills MN
Ling Chen - Roseville MN
Paul Bradley Addis - St. Paul MN
Jack Edgar Johnson - Waseca MN

Assignee:

Regents of the University of Minnesota - Minneapolis MN
Agricultural Utilization Research Institute - Crookston MN

International Classification:

A23L 105

US Classification:

426578, 426661, 426506, 426518, 426519, 162 90, 162 96, 162 99, 162176

Abstract:

An improved method for refining cellulose that produces a highly refined cellulosic material comprising soaking raw material in a mild NaOH using reduced temperatures and pressures, and refining the material with a plate refiner so that a waste water stream is reduced in volume and has a pH within a range of 8 to 9. Also, a HRC gel having a lignin concentration of at least about one (1)% by weight, and a water retention capacity of about 25 to at least about 56 g H O/g dry HRC is provided.

US Patent:

7074300, Jul 11, 2006

Filed:

Nov 25, 2002

Appl. No.:

10/303256

Inventors:

Brock Lundberg - St. Paul MN, US
Lin Gu - St. Paul MN, US
Rongsheng Roger Ruan - Arden Hills MN, US
Ling Chen - Roseville MN, US
Paul Bradley Addis - St. Paul MN, US
Jack Edgar Johnson - Waseca MN, US

Assignee:

Regents of the University of Minnesota - Minneapolis MN
Agricultural Utilization Research Institute - Crookston MN

International Classification:

B29D 23/00
A23L 1/05
D21C 3/02

US Classification:

162 90, 162 96, 162 99, 162176, 426578, 426661, 426506, 426518, 426519, 428 348

Abstract:

The present invention comprises an improved method for refining cellulose that produces a highly refined cellulosic material. The method comprises soaking raw material in a mild NaOH using reduced temperatures and pressures, and refining the material with a plate refiner so that a waste water stream is reduced in volume and has a pH within a range of 8 to 9. The present invention also comprises a HRC gel having a lignin concentration of at least about one (1)% by weight, and a water retention capacity of about 25 to at least about 56 g HO/g dry HRC.

US Patent:

8017733, Sep 13, 2011

Filed:

Jul 16, 2004

Appl. No.:

10/892830

Inventors:

KoChung Lin - Lexington MA, US
R. Blake Pepinsky - Arlington MA, US
Ling Ling Chen - Wellesley MA, US
Donna M. Hess - Waltham MA, US
Edward Y. Lin - Somerville MA, US
Russell C. Petter - Stow MA, US
Darren P. Baker - Hingham MA, US

Assignee:

Biogen Idec MA Inc. - Cambridge MA

International Classification:

C07K 17/08
C07K 14/565
C11D 3/38
C08G 59/00
C08G 59/14
C11D 3/386

US Classification:

530351, 435 6951, 436 86, 510320, 525525, 525526

Abstract:

The invention relates to novel polyalkylene glycol compounds and methods of using them. In particular, compounds comprising a novel polyethylene glycol conjugate are used alone, or in combination with antiviral agents to treat a viral infection, such as chronic hepatitis C.

US Patent:

8524660, Sep 3, 2013

Filed:

Sep 12, 2011

Appl. No.:

13/230080

Inventors:

KoChung Lin - Lexington MA, US
R. Blake Pepinsky - Arlington MA, US
Ling Ling Chen - Wellesley MA, US
Donna M. Hess - Waltham MA, US
Edward Y. Lin - Somerville MA, US
Russell C. Petter - Stow MA, US
Darren P. Baker - Hingham MA, US

Assignee:

Biogen Idec MA Inc. - Cambridge MA

International Classification:

A61K 47/48
C08G 65/329
A61K 38/00
C07K 17/08
A61K 31/00
A61K 38/21
C07K 14/565
C12N 15/22

US Classification:

514 43, 514 179, 514 37, 514 23, 514 11, 514 1, 435 6951, 436 86, 510320, 525525, 525526, 530351

Abstract:

The invention relates to novel polyalkylene glycol compounds and methods of using them. In particular, compounds comprising a novel polyethylene glycol conjugate are used alone, or in combination with antiviral agents to treat a viral infection, such as chronic hepatitis C.

US Patent:

8641872, Feb 4, 2014

Filed:

Sep 16, 2009

Appl. No.:

13/119672

Inventors:

Rongsheng Ruan - Arden Hills MN, US
Shaobo Deng - Eden Prairie MN, US
Zhiping Le - Jiangxi, CN
Yanling Cheng - Beijing, CN
Xiangyang Lin - Fujian, CN
Ling Chen - Roseville MN, US

Assignee:

Regents of the University of Minnesota - St. Paul MN

International Classification:

B01J 19/12
C01C 1/04

US Classification:

20415746, 20415752

Abstract:

The disclosure herein describes a method for producing ammonia by introducing N, CO and water into a non-thermal plasma in the presence of a catalyst, the catalyst being effective to promote the disassociation of N, CO and water to form reactants that in turn react to produce NHand CH. This disclosure also describes producing a reactive hydrogen ion or free radical by the method comprising passing water through a non-thermal plasma in the presence of a catalyst, the catalyst being effective to promote the dissociation of water.

US Patent:

62076485, Mar 27, 2001

Filed:

Jul 17, 1998

Appl. No.:

9/118179

Inventors:

David J. Waxman - Newton MA
Ling Chen - Blue Bell PA

Assignee:

Trustees of Boston University - Boston MA

International Classification:

A01N43/04
7
C12N15/00
15/63
7
C07H21/04

US Classification:

514 44

Abstract:

Methods of killing neoplastic cells are provided. The invention relates to the use of NADPH-cytochrome P450 reductase (RED) gene transfer in combination with cytochrome P450 gene transfer to enhance the sensitivity of tumor cells to anti-cancer drugs that are activated by P450 enzymes. The use of bioreductive drugs that are activated by RED and/or cytochrome P450, in this paradigm, is also provided.

US Patent:

56887736, Nov 18, 1997

Filed:

Oct 28, 1994

Appl. No.:

8/330523

Inventors:

E. Antonio Chiocca - Boston MA
David J. Waxman - Newton Centre MA
Ming X. Wei - Somerville MA
Xandra O. Breakefield - Newton MA
Ling Chen - Brookline MA

Assignee:

The General Hospital Corporation - Boston MA
Boston University - Boston MA
Dana-Farber Cancer Institute - Boston MA

International Classification:

A61K 4800
C12N 500
C12N 1500
C07N 1400

US Classification:

514 44

Abstract:

A method for selectively killing nervous system and peripheral neoplastic cells is provided. Viral vectors are used to selectively express a cytochrome P450 gene in neoplastic cells, whose gene product targets the cells for selective killing, by rendering the cells sensitive to a chemotherapeutic agent.

US Patent:

58173811, Oct 6, 1998

Filed:

Nov 13, 1996

Appl. No.:

8/748373

Inventors:

Ling Chen - Roseville MN
Rongsheng Roger Ruan - New Hope MN
Jack Edgar Johnson - Waseca MN
Paul Bradley Addis - St. Paul MN
Li Xu - St. Paul MN
Lun Yi - St. Paul MN

Assignee:

Agricultural Utilization Research Institute - Minneapolis MN
Regents of the University of Minnesota - Waseca MN

International Classification:

C08B 322

US Classification:

428 348

Abstract:

A process and materials are described in which highly refined celleuloise fibers are broken down into microfibers and further processed into compositions, films. coatings and solid materials which are biodegradable and even edible. The process for the formation of hardenable compositions may comprise:providing a composition comprising non-wood cellulose fiber, 36. mechanically reducing the size of the non-wood cellulose fiber to less than 2 mm, reducing the amount of binding of microfibers by lignin within said non-wood cellulose fibers present in said composition comprising cellulose fiber to form a first fiber product, providing pressure of at least 300 psi to said first fiber product while it is in the presence of a liquid, and removing said pressure within a time interval which will cause said cellulose fiber to break down into a second fiber product comprising microfibers in said liquid.