Ling S Li

US Patent:

6653318, Nov 25, 2003

Filed:

Jul 21, 1999

Appl. No.:

09/358028

Inventors:

Yung-Chi Cheng - Woodbridge CT
Chung K. Chu - Athens GA
Ling Li - Hamden CT
Yongseok Chai - Athens GA

Assignee:

Yale University - New Haven CT
The University of Georgia Research Foundation, Inc. - Athens GA

International Classification:

A61K 31505

US Classification:

514274, 514256, 514269, 514272, 514467, 514461

Abstract:

The present invention relates to pyrimidine nucleoside compounds and their use to treat viral infections of Varicella Zoster virus and Epstein Barr Virus, as well as cancers which are complications of Epstein Barr virus.

US Patent:

7244717, Jul 17, 2007

Filed:

Aug 21, 2002

Appl. No.:

10/226799

Inventors:

Ling Li - Seattle WA, US
Alexander Gall - Woodinville WA, US
Richard Daifuku - Mercer Island WA, US

Assignee:

Koronis Pharmaceuticals, Incorporated - Redmond WA

International Classification:

A61K 31/70
C07H 19/067
C07H 19/09

US Classification:

514 50, 514 51, 536 2854, 536 274

Abstract:

The present invention relates to methods of treating viral disease using mutagenic nucleoside analogs. In particular, the invention provides 5-aldehydo-uracil nucleosides and derivatives thereof, and methods of administration thereof to increase the virus mutation rate in a virally infected cell.

US Patent:

7648967, Jan 19, 2010

Filed:

Feb 13, 2006

Appl. No.:

11/353489

Inventors:

Ling Li - Seattle WA, US
Alexander Gall - Woodinville WA, US
Richard Daifuku - Mercer Island WA, US

Assignee:

Koronis Pharmaceuticals, Incorporated - Redmond WA

International Classification:

A61K 31/70
C07H 19/167
C07H 19/173
C07H 19/20
C12P 19/40
C12P 19/30
C12P 19/34

US Classification:

514 45, 514 48, 435 88, 435 89, 435 9121, 536 2626, 536 267, 536 277

Abstract:

The present invention relates to methods of treating viral disease using mutagenic nucleoside analogs. In particular, the invention provides isoguanosine nucleosides and derivatives thereof as well a method of increasing the mutation rate of a virus such as bovine viral diarrhea virus (BVDV) and hepatitis C virus (HCV).

US Patent:

7754718, Jul 13, 2010

Filed:

May 2, 2005

Appl. No.:

11/579284

Inventors:

Hosup Yeo - Daegu, KR
David J. Austin - New York NY, US
Ling Li - Bellaire TX, US
Yung-chi Cheng - Woodbridge CT, US

Assignee:

Yale University - New Haven CT

International Classification:

A61K 31/502
C07D 237/26

US Classification:

514248, 544233

Abstract:

The present invention relates to novel antiviral helioxanthin analogs. These compounds may particularly be used alone or in combination with other drugs for the treatment of the following: hepadnaviruses, flaviviruses, herpesviruses and human immunodeficiency virus. In addition, compounds according to the present invention can be used to prevent or reduce the likelihood of the occurrence of tumors secondary to virus infection as well as other infections or disease states that are secondary to the virus infection.

US Patent:

20040053891, Mar 18, 2004

Filed:

Sep 2, 2003

Appl. No.:

10/653538

Inventors:

Yung-Chi Cheng - Woodbridge CT, US
Chung Chu - Athens GA, US
Ling Li - Hamden CT, US

International Classification:

A61K031/675
A61K031/513

US Classification:

514/085000, 514/269000

Abstract:

The present invention relates to pyrimidine nucleoside compounds and their use to treat viral infections of Varicella Zoster Virus, Epstein Barr Virus and Kaposi's Sarcoma virus, also known as HV-8 and related complications of these viral infections. In another aspect of the present invention, the use of one or more nucleoside compound to increase the retention or half-life of 5-fluorouracil (FU) in patients is also described.

US Patent:

20100279968, Nov 4, 2010

Filed:

Dec 27, 2006

Appl. No.:

11/616622

Inventors:

Ling Li - Seattle WA, US
Alexander Gall - Woodinville WA, US
Richard Daifuku - Mercer Island WA, US

Assignee:

Koronis Pharmaceuticals, Inc. - Redmond WA

International Classification:

A61K 31/708
C12N 7/06
A61K 31/7072
A61P 31/16
A61P 31/14
A61P 31/20
C07H 19/06
C07H 19/16
A61P 31/18

US Classification:

514 45, 435238, 514 50, 536 2853, 536 277

Abstract:

The present invention relates to methods of treating viral disease using mutagenic nucleoside analogs.

US Patent:

20200201650, Jun 25, 2020

Filed:

Dec 20, 2018

Appl. No.:

16/228663

Inventors:

- Redmond WA, US
Jianshu JI - Seattle WA, US
Hao PENG - Kirkland WA, US
Ling LI - Bellevue WA, US

Assignee:

Microsoft Technology Licensing, LLC - Redmond WA

International Classification:

G06F 9/38
G06F 11/36
G06F 11/30
G06F 11/07

Abstract:

A computer processing pipeline is automatically computer monitored. The computer processing pipeline includes a plurality of ordered computer stages. At least one computer stage is configured to receive an input data set and perform one or more computer processing operations on the input data set to produce an output data set. The output data set is provided as input to another computer stage of the computer processing pipeline. A historical expected schedule is automatically computer generated for compliant execution of the at least one computer stage. The output data set is automatically computer sampled at a designated time dictated by the historical expected schedule. The sampled output data set is automatically computer tested for compliance with one or more detection rules. An anomaly alert that identifies one or more anomalies is automatically computer issued based on non-compliance of the output data set with the one or more detection rules.

US Patent:

20200117742, Apr 16, 2020

Filed:

Oct 15, 2018

Appl. No.:

16/160886

Inventors:

- Redmond WA, US
Mridu Baldevraj NARANG - Redmond WA, US
Ling LI - Bellevue WA, US
Guihong CAO - Sammamish WA, US

Assignee:

Microsoft Technology Licensing, LLC - Redmond WA

International Classification:

G06F 17/30

Abstract:

A method for determining whether to dynamically suppress a candidate query answer designated for inclusion in search results includes instantiating a plurality of filtering rules for assessing suppression of a candidate query answer. The filtering rules include one or both of a pattern rule and a site rule. The method further comprises receiving a query, and, after receiving the query, retrieving one or more candidate query answers previously associated with the query. The method further comprises, for each candidate query answer, dynamically suppressing the candidate query answer from a curated position having enhanced prominence within search results relative to a plurality of other result entries, if either or both of a pattern rule and a site rule match the query. The method further includes returning search results including up to one candidate query answer in the curated position, responsive to a candidate query answer not being dynamically suppressed.