Ling Ling Tang

US Patent:

20210002716, Jan 7, 2021

Filed:

Jul 13, 2020

Appl. No.:

16/927898

Inventors:

- Grand Cayman, KY
Shengrong LIN - Fremont CA, US
Ling Fung TANG - San Francisco CA, US

International Classification:

C12Q 1/6853
C12Q 1/6858
C12Q 1/68
G16B 25/00

Abstract:

In some aspects, the present disclosure provides methods for enriching amplicons, or amplification products, comprising a concatemer of at least two or more copies of a target polynucleotide. In some embodiments, a method comprises sequencing the amplicons comprising at least two or more copies of a target polynucleotide. In some embodiments, the target polynucleotides comprise sequences resulting from chromosome rearrangement, including but not limited to point mutations, single nucleotide polymorphisms, insertions, deletions, and translocations including fusion genes. In some aspects, the present disclosure provides compositions and reaction mixtures useful in the described methods.

US Patent:

20200010884, Jan 9, 2020

Filed:

May 16, 2017

Appl. No.:

16/301707

Inventors:

- George Town, Grand Cayman, KY
Shengrong LIN - Fremont CA, US
Ling Fung TANG - San Francisco CA, US
Yontao LU - Sunnyvale CA, US
Zhaohui SUN - Albany CA, US
Yingyu WANG - Mountain View CA, US
Li WENG - Fremont CA, US

International Classification:

C12Q 1/6869
C40B 50/06
C12Q 1/6827
C12Q 1/6858

Abstract:

In some aspects, the present disclosure provides methods for identifying sequence variants, as well as methods of determining copy number of a genetic locus in a sample. Systems and kits for performing methods of the disclosure, as well as compositions produced by or useful in methods of the disclosure are also provided. In some embodiments, methods comprise extending 3′ ends of polynucleotides by adding one or more pre-determined nucleotides. In some embodiments, methods comprise use of a strand-tagging sequence.

US Patent:

20180298434, Oct 18, 2018

Filed:

Apr 6, 2018

Appl. No.:

15/947100

Inventors:

- Grand Cayman, KY
Shengrong Lin - Fremont CA, US
Ling Fung Tang - San Francisco CA, US

International Classification:

C12Q 1/6853
C12Q 1/6858

Abstract:

In some aspects, the present disclosure provides methods for enriching amplicons, or amplification products, comprising a concatemer of at least two or more copies of a target polynucleotide. In some embodiments, a method comprises sequencing the amplicons comprising at least two or more copies of a target polynucleotide. In some embodiments, the target polynucleotides comprise sequences resulting from chromosome rearrangement, including but not limited to point mutations, single nucleotide polymorphisms, insertions, deletions, and translocations including fusion genes. In some aspects, the present disclosure provides compositions and reaction mixtures useful in the described methods.

US Patent:

20180128936, May 10, 2018

Filed:

Jul 10, 2017

Appl. No.:

15/645672

Inventors:

- Torrance CA, US
Ling Tang - Newton MA, US
Jing Ye Shea - Groveland MA, US
Minyang Huang - Andover MA, US
Jolyon Browne - San Jose CA, US

International Classification:

G01V 5/00
G01N 23/04

Abstract:

The present specification discloses methods for scanning objects for the presence of lithium batteries. Normalized transmission X-ray data is used to generate organic, effective Z, and attenuation-based images. These images are then segmented using a combination of thresholding and region growing techniques to identify regions of interest. The regions are classified as lithium batteries or other objects, based on characteristics such as area of the region, its organic intensity, Znumber, shape, spatial arrangement and texture.

US Patent:

20160084984, Mar 24, 2016

Filed:

Jul 15, 2015

Appl. No.:

14/800595

Inventors:

- Torrance CA, US
Ling Tang - Newton MA, US
Jing Ye Shea - Groveland MA, US
Minyang Huang - Andover MA, US
Jolyon Browne - San Jose CA, US

International Classification:

G01V 5/00
G01N 23/04

Abstract:

The present specification discloses methods for scanning objects for the presence of lithium batteries. Normalized transmission X-ray data is used to generate organic, effective Z, and attenuation-based images. These images are then segmented using a combination of thresholding and region growing techniques to identify regions of interest. The regions are classified as lithium batteries or other objects, based on characteristics such as area of the region, its organic intensity, Znumber, shape, spatial arrangement and texture.