Ling Chen Yu

US Patent:

20120148598, Jun 14, 2012

Filed:

Dec 1, 2011

Appl. No.:

13/309490

Inventors:

Soldano Ferrone - Pittsburgh PA, US
Xinhui Wang - Pittsburgh PA, US
Elvira Favoino - Bari, IT
Ling Yu - Pittsburgh PA, US
Yangyang Wang - Pittsburgh PA, US

International Classification:

A61K 39/395
A61P 35/04
A61P 35/00

US Classification:

4241561

Abstract:

Combinations of agents that have a synergistic effect for the treatment of a tumor are disclosed herein. These combinations of agents can be used to treat tumors, wherein the cells of the cancer express a mutated BRAF. Methods are disclosed for treating a subject diagnosed with a tumor that expresses a mutated BRAF. The methods include administering to the subject (1) a therapeutically effective amount of an antibody or antigen binding fragment thereof that specifically binds glucose regulated protein (GRP) 94; and (2) a therapeutically effective amount of a BRAF inhibitor. In some embodiments, the tumor is melanoma. In some embodiments the method includes selecting a subject with primary or secondary resistance to a BRAF inhibitor. In further embodiments, treating the tumor comprises decreasing the metastasis of the tumor. In additional embodiments, the BRAF inhibitor comprises PLX4032 or PLX4720.