Ling Zhang

US Patent:

20130060000, Mar 7, 2013

Filed:

May 26, 2011

Appl. No.:

13/696918

Inventors:

Ling Zhang - Missouri City TX, US
Daniel A. Aguilar - Lake Jackson TX, US
Debkumar Bhattacharjee - Blue Bell PA, US
William A. Koonce - Pearland TX, US
Basudeb Saha - Missouri City TX, US

Assignee:

DOW GLOBAL TECHNOLOGIES LLC - Midland MI

International Classification:

C07F 7/02
C08G 18/73
C08G 18/71

US Classification:

528 67, 528 75, 556444

Abstract:

Embodiments of the invention provide for a method of producing a silylated polyoxyalkylene polymer having at least one crosslinkable silyl group and at least one hydroxyl group in each molecule. The method comprises providing a polyoxyalkylene polymer having at least one unsaturated group and at least one alcoholic hydroxyl group in each molecule, wherein the polyoxyalkylene polymer includes an impurity double metal cyanide complex mixed therein, and wherein the polyoxyalkylene polymer has not been treated with a metal-coordinating compound; and adding to the polyoxyalkylene polymer a compound having a hydrogen-silicon bond and a crosslinkable silyl group in each molecule and a hydrosilylation catalyst to thereby carry out a hydrosilylation reaction, wherein the hydrosilyation reaction is performed in an absence of a metal-coordinating compound.

US Patent:

20130090429, Apr 11, 2013

Filed:

Jun 29, 2011

Appl. No.:

13/805952

Inventors:

Ling Zhang - Missouri City TX, US
Kamesh R. Vyakaranam - Pearland TX, US
Sara Arshad - West Springfield MA, US
William A. Koonce - Pearland TX, US

Assignee:

DOW GLOBAL TECHNOLOGIES LLC - Midland MI

International Classification:

C08G 18/38

US Classification:

524590, 525460

Abstract:

Embodiment of the invention provide for compositions having at least one crosslinkable silyl group in each molecule. The crosslinkable silane-terminated polymer may include a reaction product of at least a polyol having a nominal functionality of at least 2 and a isocyanate capped hydrosilylated polymer. The isocyanate capped hydrosilylated polymer may include a reaction product of at least one isocyanate and a hydrosilylated polymer. The hydrosilylated polymer may include a reaction product of a the reaction of at least a) a polymer having at least one unsaturated group and at least one alcoholic hydroxyl group in each molecule and having a number average molecular weight of between about 100 and about 5000 and b) a compound having a hydrogen-silicon bond and a crosslinkable silyl group in each molecule.

US Patent:

20130096252, Apr 18, 2013

Filed:

Jun 29, 2011

Appl. No.:

13/704162

Inventors:

Kamesh R. Vyakaranam - Pearland TX, US
Ling Zhang - Missouri City TX, US
William A. Koonce - Pearland TX, US
Juan Carlos Medina - Lake Jackson TX, US
Ganesh Kailasam - Pearland TX, US
Rajat Duggal - Pearland TX, US
Nathan Wilmot - Missouri City TX, US

Assignee:

DOW GLOBAL TECHNOLOGIES LLC - Midland MI

International Classification:

C08G 18/22
C08G 18/38

US Classification:

524588, 528 28, 528 15, 528 21, 528 23, 528 13

Abstract:

Embodiments of the invention provide for methods of producing a composition comprising a crosslinkable silane-terminated polymer having at least one crosslinkable silyl group in each molecule. The method comprises providing a polymer having at least one unsaturated group and at least one alcoholic hydroxyl group in each molecule, adding to the polymer a compound having a hydrogen-silicon bond and a crosslinkable silyl group in each molecule and a hydrosilylation catalyst to thereby carry out a hydrosilylation reaction to form a composition comprising hydrosilylated polyoxyalkylene polymers, reacting the hydrosilylated polyoxyalkylene polymers with at least one isocyanate in the presence of a first tin-free catalyst to form an isocyanate reacted hydrosilylated polymer, and optionally reacting the isocyanate reacted hydrosilylated polymer with a polyol having a nominal functionality of at least 2 to form a polyol reacted crosslinkable silane-terminated polymer.

US Patent:

20130096274, Apr 18, 2013

Filed:

Jun 28, 2011

Appl. No.:

13/806962

Inventors:

Kameswara R. Vyakaranam - Pearland TX, US
Ling Zhang - Missouri City TX, US
William A. Koonce - Pearland TX, US
Sara Arshad - West Springfield MA, US
Venkat S. Minnikanti - Pearland TX, US
Dwight D. Latham - Clute TX, US
Phillip S. Athey - Lake Jackson TX, US

Assignee:

DOW GLOBAL TECHNOLOGIES LLC - Midland MI

International Classification:

C08G 18/70

US Classification:

528 29

Abstract:

Embodiments of the invention provide for compositions including a crosslinkable silane-terminated polymer having at least one crosslinkable silyl group in each molecule. The crosslinkable silane-terminated polymer comprises a reaction product of at least a isocyanate capped hydrosilylated polymer and a polyol having a nominal functionality of at least 2 which is at least one of a polycarbonate polyol, a natural oil based polyol, a polyoxyalkyleneamine, a difunctional aromatic amine, a polybutyloxide polyether polyol, and a polytetramethylene glycol.

US Patent:

20200085929, Mar 19, 2020

Filed:

Aug 19, 2019

Appl. No.:

16/543980

Inventors:

- Austin TX, US
Hiroki TORIKAI - Houston TX, US
Ling ZHANG - Houston TX, US
Helen HULS - Houston TX, US
Lenka HURTON - Houston TX, US
Simon OLIVARES - Houston TX, US
Janani KRISHNAMURTHY - Houston TX, US

International Classification:

A61K 39/00
A61P 37/00
C07K 14/725
A61K 35/17
C07K 14/54
C07K 14/705
C07K 16/30

Abstract:

The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment.

US Patent:

20170224798, Aug 10, 2017

Filed:

Feb 16, 2017

Appl. No.:

15/434595

Inventors:

- Austin TX, US
Hiroki TORIKAI - Houston TX, US
Ling ZHANG - Houston TX, US
Helen HULS - Houston TX, US
Lenka HURTON - Houston TX, US
Simon OLIVARES - Houston TX, US
Janani KRISHNAMURTHY - Houston TX, US

International Classification:

A61K 39/00
C07K 14/705
C07K 14/725
C07K 16/30

Abstract:

The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment.

US Patent:

20160158285, Jun 9, 2016

Filed:

May 14, 2014

Appl. No.:

14/890977

Inventors:

- Austin TX, US
Hiroki TORIKAI - Houston TX, US
Ling ZHANG - Houston TX, US
Helen HULS - Houston TX, US
Lenka HURTON - Houston TX, US
Simon OLIVARES - Houston TX, US
Janani KRISHNAMURTHY - Houston TX, US

International Classification:

A61K 35/17
C07K 14/54

Abstract:

The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment.

US Patent:

20150011722, Jan 8, 2015

Filed:

Sep 25, 2014

Appl. No.:

14/496269

Inventors:

- Midland MI, US
Ling Zhang - Missouri City TX, US
William A. Koonce - Pearland TX, US
Juan Carlos Medina - Lake Jackson TX, US
Ganesh Kailasam - Pearland TX, US
Rajat Duggal - Pearland TX, US
Nathan Wilmot - Missouri City TX, US

International Classification:

C08G 18/50
C08G 18/20
C08G 18/22
C08G 18/76

US Classification:

528 19, 528 28, 528 21

Abstract:

Embodiments of the invention provide for methods of producing a composition comprising a crosslinkable silane-terminated polymer having at least one crosslinkable silyl group in each molecule. The method comprises providing a polymer having at least one unsaturated group and at least one alcoholic hydroxyl group in each molecule, adding to the polymer a compound having a hydrogen-silicon bond and a crosslinkable silyl group in each molecule and a hydrosilylation catalyst to thereby carry out a hydrosilylation reaction to form a composition comprising hydrosilylated polyoxyalkylene polymers, reacting the hydrosilylated polyoxyalkylene polymers with at least one isocyanate in the presence of a first tin-free catalyst to form an isocyanate reacted hydrosilylated polymer, and optionally reacting the isocyanate reacted hydrosilylated polymer with a polyol having a nominal functionality of at least 2 to form a polyol reacted crosslinkable silane-terminated polymer.