Linh T Tran

US Patent:

7097850, Aug 29, 2006

Filed:

Jun 18, 2002

Appl. No.:

10/175210

Inventors:

Ralph A. Chappa - Prior Lake MN, US
Robert W. Hergenrother - Eden Prairie MN, US
Aron B. Anderson - Minnetonka MN, US
Linh V. Tran - Brooklyn Park MN, US
Laurie R. Lawin - New Brighton MN, US
Ronald F. Ofstead - Maplewood MN, US

Assignee:

SurModics, Inc. - Eden Prairie MN

International Classification:

A61F 2/02

US Classification:

424423

Abstract:

A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).

US Patent:

7833548, Nov 16, 2010

Filed:

Aug 19, 2005

Appl. No.:

11/207380

Inventors:

Ralph A. Chappa - Prior Lake MN, US
Robert W. Hergenrother - Eden Prairie MN, US
Aron B. Anderson - Minnetonka MN, US
Linh V. Tran - Brooklyn Park MN, US
Laurie R. Lawin - New Brighton MN, US
Ronald F. Ofstead - Maplewood MN, US

Assignee:

Surmodics, Inc. - Eden Prairie MN

International Classification:

A61K 9/14

US Classification:

424486

Abstract:

A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).

US Patent:

20020188037, Dec 12, 2002

Filed:

Jun 18, 2002

Appl. No.:

10/175212

Inventors:

Stephen Chudzik - St. Paul MN, US
Timothy Kloke - Eden Prairie MN, US
Laurie Lawin - New Brighton MN, US
Ronald Ofstead - Maplewood MN, US
Ralph Chappa - Prior Lake MN, US
Robert Hergenrother - Eden Prairie MN, US
Aron Anderson - Minnetonka MN, US
Linh Tran - Brooklyn Park MN, US

International Classification:

A01N001/00

US Classification:

523/112000

Abstract:

A coating composition, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a combination of a first polymer component such as polyalyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).

US Patent:

20030232087, Dec 18, 2003

Filed:

Jun 18, 2002

Appl. No.:

10/174635

Inventors:

Laurie Lawin - New Brighton MN, US
Ronald Ofstead - Maplewood MN, US
Ralph Chappa - Prior Lake MN, US
Robert Hergenrother - Eden Prairie MN, US
Aron Anderson - Minnetonka MN, US
Linh Tran - Brooklyn Park MN, US

International Classification:

A61K031/74
A61K009/14

US Classification:

424/487000, 523/122000

Abstract:

A coating composition, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a combination of a first polymer component such as polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).

US Patent:

20100158799, Jun 24, 2010

Filed:

Mar 3, 2010

Appl. No.:

12/716753

Inventors:

Stephen J. Chudzik - St. Paul MN, US
Timothy M. Kloke - Victoria MN, US
Laurie R. Lawin - St. Paul MN, US
Ronald F. Ofstead - Maplewood MN, US
Ralph A. Chappa - Ham Lake MN, US
Robert W. Hergenrother - Eden Prairie MN, US
Aron B. Anderson - Eden Prairie MN, US
Linh V. Tran - Little Canada MN, US

Assignee:

SurModics, Inc. - Eden Prairie MN

International Classification:

A61K 51/00
A61K 47/32
A61K 31/7052
A61K 31/56
A61K 38/02
A61K 38/16
A61K 38/43
A61P 43/00

US Classification:

424 111, 5147724, 514 44 A, 514169, 514 2, 514 12, 424 941, 514 44 R

Abstract:

A composition for bioactive agent release in vivo. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).

US Patent:

20110054417, Mar 3, 2011

Filed:

Nov 8, 2010

Appl. No.:

12/941132

Inventors:

Ralph A. Chappa - Ham Lake MN, US
Robert W. Hergenrother - Eden Prairie MN, US
Aron B. Anderson - Minnetonka MN, US
Linh V. Tran - Little Canada MN, US
Laurie R. Lawin - St. Paul MN, US
Ronald F. Ofstead - Maplewood MN, US

Assignee:

SurModics, Inc. - Eden Prairie MN

International Classification:

A61L 29/14
B05D 7/00

US Classification:

604265, 604544, 427 21, 427 225, 427 23

Abstract:

A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).