Jianguo Ji - Libertyville IL, US Tao Li - Grayslake IL, US Kathleen Mortell - Chicago IL, US Michael Schrimpf - Grayslake IL, US Diana Nersesian - Gurnee IL, US Liping Pan - Gurnee IL, US William Bunnelle - Mundelein IL, US
Compounds of formula (I) wherein n is 0, 1, or 2; A is N or N—O—; X is O, S, —NH—, and —N-alkyl-; Aris a 6-membered aromatic ring; and Aris a fused bicycloheterocycle. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.
Jeffrey Rohde - Evanston IL, US Liping Pan - Gurnee IL, US Marina Pliushchev - Vernon Hills IL, US James Link - Evanston IL, US
International Classification:
A61K 31/41 A61K 31/19 A61K 31/18
US Classification:
514381000, 514557000, 514602000, 514623000
Abstract:
The present invention is directed to the method of increasing the metabolic stability of adamantane containing compounds that are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 (11-beta-HSD-1) enzyme. The stability is achieved by substitutions of the adamantane ring.
Jianguo Ji - Libertyville IL, US Tao Li - Grayslake IL, US Kathleen Mortell - Chicago IL, US Michael Schrimpf - Grayslake IL, US Diana Nersesian - Gurnee IL, US Liping Pan - Gurnee IL, US William Bunnelle - Mundelein IL, US
Compounds of formula (I) wherein n is 0, 1, or 2; A is N or N—O; X is O, S, —NH—, and —N-alkyl-; Aris a 6-membered aromatic ring; and Aris a fused bicycloheterocycle. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.
Jianguo Ji - Libertyville IL, US Tao Li - Grayslake IL, US Kathleen Mortell - Chicago IL, US Michael Schimpf - Grayslake IL, US Diana Nersesian - Gurnee IL, US Liping Pan - Gurnee IL, US
Compounds of formula (I) wherein n is 0, 1, or 2; A is N or N—O; X is O, S, —NH—, and —N-alkyl-; Aris a 6-membered aromatic ring; and Aris a fused bicycloheterocycle. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.
ductions in fruit juice purchases, increases in (healthy eating) and fruit, vegetable and whole grain consumption, better access to healthy foods in communities, and improved WIC staff competence in providing counseling for overweight children, said study leader Dr. Liping Pan, a researcher at the U.S. C
Date: Jan 08, 2018
Category: Health
Source: Google
At least 20% of adults are obese in every U.S. state, CDC maps show
The maps show the prevalence of obesity among U.S. adults remains relatively high, despite nationwide efforts in recent years to boost families' access to healthier foods and encourage exercise, Dr. Liping Pan, an epidemiologist in CDC's Obesity Prevention and Control program, told Mashable.