Lisa A Fitzgerald

US Patent:

6383793, May 7, 2002

Filed:

Aug 20, 1997

Appl. No.:

08/915095

Inventors:

Gregg A. Hastings - Rockville MD
Mark D. Adams - Potomac MD
Claire M. Fraser - Gueenstown MD
Norman H. Lee - Woodstock MD
Ewen F. Kirkness - Washington DC
Judith A. Blake - Laurel MD
Lisa M. Fitzgerald - Germantown MD
Fred H. Drake - Glenmoore PA
Maxine Gowan - Valley Forge PA

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C12N 964

US Classification:

435226, 435183, 435212, 4352523, 4353201, 435325, 43525411, 435 691, 536 231, 536 232, 536 235

Abstract:

Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.

US Patent:

6387682, May 14, 2002

Filed:

Feb 12, 1997

Appl. No.:

08/798096

Inventors:

Gregg A. Hastings - Rockville MD
Mark D. Adams - Potomac MD
Claire M. Fraser - Gueenstown MD
Norman H. Lee - Woodstock MD
Ewen F. Kirkness - Washington DC
Judith A. Blake - Laurel MD
Lisa M. Fitzgerald - Germantown MD
Fred H. Drake - Glenmoore PA
Maxine Gowan - Valley Forge PA

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C12N 964

US Classification:

435226, 435183, 435212, 435 691, 4353201, 4352523, 530350, 514 1, 514525

Abstract:

Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.

US Patent:

6423507, Jul 23, 2002

Filed:

Feb 12, 1997

Appl. No.:

08/798095

Inventors:

Gregg A. Hastings - Rockville MD
Mark D. Adams - Potomac MD
Claire M. Fraser - Gueenstown MD
Norman H. Lee - Woodstock MD
Ewen F. Kirkness - Washington DC
Judith A. Blake - Laurel MD
Lisa M. Fitzgerald - Germantown MD
Fred H. Drake - Glenmoore PA
Maxine Gowan - Valley Forge PA

Assignee:

Human Genome Sciences, Inc. - Rockville MD
Smithkline Beecham Corporation - Philadelphia PA

International Classification:

C12Q 137

US Classification:

435 23, 435219, 435226, 435 4, 435183

Abstract:

Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.

US Patent:

6475766, Nov 5, 2002

Filed:

Nov 7, 1995

Appl. No.:

08/553125

Inventors:

Gregg A. Hastings - Rockville MD
Mark D. Adams - Potomac MD
Claire M. Fraser - Gueenstown MD
Norman H. Lee - Woodstock MD
Ewen F. Kirkness - Washington DC
Judith A. Blake - Laurel MD
Lisa M. Fitzgerald - Germantown MD
Fred H. Drake - Glenmoore PA
Maxine Gowan - Valley Forge PA

Assignee:

Human Genome Sciences, Inc. - Rockville MD
SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C12N 964

US Classification:

435226, 435212, 435183, 435 691, 4353201, 4352523, 530350, 514 1, 514525

Abstract:

Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.

US Patent:

20030166863, Sep 4, 2003

Filed:

Jun 25, 2002

Appl. No.:

10/178731

Inventors:

Haodong Li - Gaithersburg MD, US
Lisa Fitzgerald - Germantown MD, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C07K014/52
C07H021/04
C12P021/02
C12N005/06

US Classification:

530/351000, 536/023500, 435/069500, 435/320100, 435/325000

Abstract:

The present invention relates to a human MIF-3 and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the polypeptide therapeutically for treating cancer, infections, acceleration of wound healing, stimulating the immune system, as an anti-inflammatory. Methods of using antibodies and antagonists for therapeutic purposes, is also disclosed, for example, for treating lethal endotoxaemia, ocular inflammation and diagnosing immune diseases. Also disclosed are diagnostic methods for detecting conditions related to a mutation in a nucleic acid sequence encoding a polypeptide of the present invention and altered levels of the polypeptide of the present invention.

US Patent:

20100199907, Aug 12, 2010

Filed:

Feb 5, 2010

Appl. No.:

12/700759

Inventors:

Bradley R. Ringeisen - Lorton VA, US
Peter K. Wu - Ashland OR, US
Barry J. Spargo - Washington DC, US
Justin C. Biffinger - Woodbridge VA, US
Lisa A. Fitzgerald - Alexandria VA, US

Assignee:

The Government of The United States of America, as represented by the Secretary of the Navy - Washington DC

International Classification:

B63G 8/14
F17C 1/00

US Classification:

114330, 220581

Abstract:

A device having: a chamber having a gas inlet, a gas vent, and a liquid vent; and a float and a weight coupled to the chamber. The float has a lower density than the chamber. The weight has a higher density than the chamber. The aggregate density of the chamber, the float, and the weight is greater than the density of the chamber. The gas inlet, the gas vent, the liquid vent, the float, and the weight are positioned on the chamber such that: when the chamber is filled with and submerged in a liquid in which the chamber is neutrally-buoyant, the chamber is oriented to place the gas vent below the gas inlet; and when a gas is introduced through the gas inlet into the chamber that is filled with the liquid, the chamber pivots to raise the gas vent until a portion of the gas escapes from the chamber through only the gas vent.

US Patent:

20110098520, Apr 28, 2011

Filed:

Oct 27, 2010

Appl. No.:

12/913169

Inventors:

Justin C. Biffinger - Woodbridge VA, US
Lisa A. Fitzgerald - Alexandria VA, US
Cherie Ziemer - Ames IA, US
Kurt Henry - Arlington VA, US
Bradley R. Ringeisen - Lorton VA, US

Assignee:

The Government of the United States of America, as represented by the Secretary of the Navy - Washington DC

International Classification:

C07C 1/207

US Classification:

585733

Abstract:

A method of: providing a mixture of fecal waste and a bacterium; incubating the mixture to produce a fatty acid enriched mixture; removing water from the fatty acid enriched mixture to produce a dried mixture; and pyrolyzing the dried mixture in an inert atmosphere to produce an alkane from the C-Cfatty acid. The bacterium is a type that produces a C-Cfatty acid in the presence of any microbes in the fecal waste.

US Patent:

20110229951, Sep 22, 2011

Filed:

May 20, 2011

Appl. No.:

13/112368

Inventors:

Barry J. Spargo - Washington DC, US
Justin C. Biffinger - Woodbridge VA, US
Bradley R. Ringeisen - Lorton VA, US
Erinn C. Howard - Alexandria VA, US
Lisa A. Fitzgerald - Alexandria VA, US
Peter K. Wu - Ashland OR, US
Michael P. Malito - Washington DC, US

Assignee:

The Government of the United States of America, as represented by the Secretary of the Navy - Washington DC

International Classification:

C12P 5/02
C12M 1/00

US Classification:

435167, 4352891

Abstract:

Disclosed is an apparatus having: a pressure chamber and a gas-producing microorganism within the chamber. The pressure chamber is capable of maintaining a gas pressure of at least 0.5 psi above atmospheric pressure.