Lisa M Purcell

US Patent:

20130273070, Oct 17, 2013

Filed:

Apr 15, 2013

Appl. No.:

13/862497

Inventors:

Lisa A. PURCELL NGAMBO - Garnerville NY, US

Assignee:

REGENERON PHARMACEUTICALS, INC. - Tarrytown NY

International Classification:

A61K 39/395
A61K 39/145
A61K 39/42
A61K 45/06

US Classification:

4241581

Abstract:

The present invention provides methods for treating or preventing influenza virus infection. The methods of the present invention comprise administering to a subject in need thereof a pharmaceutical composition comprising a type II transmembrane serine protease (TTSP) inhibitor. The TTSP inhibitor preferably functions by inhibiting the proteolytic cleavage of influenza hemagglutinin (HA0) into the functional subunits HA1 and HA2. In certain embodiments, the TTSP inhibitor is an inhibitor of transmembrane protease serine S1 member 2 (TMPRSS2), such as an anti-TMPRSS2 antibody or antigen-binding fragment thereof.

US Patent:

20210246226, Aug 12, 2021

Filed:

Feb 9, 2021

Appl. No.:

17/171941

Inventors:

- TARRYTOWN NY, US
Christos KYRATSOUS - Irvington NY, US
Lisa PURCELL - Yorktown Heights NY, US

International Classification:

C07K 16/40
C12N 9/50
A61K 39/395
A61K 45/06

Abstract:

The present disclosure provides antibodies and antigen-binding fragments thereof that bind specifically to TMPRSS2 and methods of using such antibodies and fragments for treating or preventing viral infections (e.g., coronavirus infections or influenza virus infections).

US Patent:

20190300625, Oct 3, 2019

Filed:

Jan 24, 2019

Appl. No.:

16/256560

Inventors:

- Tarrytown NY, US
Lisa PURCELL - Garnerville NY, US

Assignee:

REGENERON PHARMACEUTICALS, INC. - Tarrytown NY

International Classification:

C07K 16/40
A61P 31/16
C07K 16/28
C07K 16/10
C12N 9/64
A61K 9/00

Abstract:

The present invention includes an antibody or antigen-binding fragment thereof that binds specifically to TMPRSS2 and methods of using such antibodies and fragments for treating or preventing viral infections (e.g., influenza virus infections).