Lisa Ann Warden

US Patent:

6750211, Jun 15, 2004

Filed:

Feb 3, 2003

Appl. No.:

10/357297

Inventors:

Lisa Warden - Stroudsburg PA
Dennis C. Liotta - Atlanta GA

Assignee:

Emory University - Atlanta GA

International Classification:

A61K 3133

US Classification:

514183, 514277, 514349, 514352, 514631, 514588, 546 1, 546289, 546304, 546339

Abstract:

Compositions, methods of use, isolation and biosynthesis of diimino-piperazine derivatives useful for the modification of sphingolipid metabolism and other biological functions are described. The preferred derivative is 2,6-bis-(-aminobutyl)-3,5-diimino-piperazine. This is a naturally occurring biochemical compound isolated from cells. The diimino-piperazine derivatives are useful as therapeutic agents when administered to patients to treat diseases and disorders involving cell regulation.

US Patent:

6552025, Apr 22, 2003

Filed:

Nov 17, 2000

Appl. No.:

09/715483

Inventors:

Lisa Warden - Stroudsburg PA
Dennis C. Liotta - Atlanta GA

Assignee:

Emory University - Atlanta GA

International Classification:

A61K 31496

US Classification:

51425501, 5142385, 5142275, 544382, 544398, 544402, 544407, 544162, 544 59

Abstract:

Compositions, methods of use, isolation and biosynthesis of diimino-piperazine derivatives useful for the modification of sphingolipid metabolism and other biological functions are described. The preferred derivative is 2,6-bis-(-aminobutyl)-3,5-diimino-piperazine. This is a naturally occurring biochemical compound isolated from cells. The diimino-piperazine derivatives are useful as therapeutic agents when administered to patients to treat diseases and disorders involving cell regulation.