In this application is the expression and purification of a recombinant (SalI) PvMSP-1 p42. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. The recombinant PvMSP-1 p42 is useful as a diagnostic reagent, for use in antibody production, and as a vaccine.
Plasmodium Falciparum Ama-1 Protein And Uses Thereof
In this application is described the expression and purification of a recombinant (3D7) AMA-1 ectodomain. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. The recombinant AMA-1 is useful as a diagnostic reagent, for use in antibody production, and as a protein for use alone, or as part of, a vaccine to prevent malaria.
Plasmodium Falciparum Ama-1 Protein And Uses Thereof
David Lanar - Takom Park MD, US Sheetij Dutta - Silver Spring MD, US Lisa Ware - Silver Spring MD, US Lalitha Nair - New Delhi, IN
International Classification:
C07H 21/02 C07H 21/04
US Classification:
536023100
Abstract:
In this application is described the expression and purification of a recombinant (3D7) AMA-1 ectodomain. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. The recombinant AMA-1 is useful as a diagnostic reagent, for use in antibody production, and as a protein for use alone, or as part of, a vaccine to prevent malaria.
Plasmodium Falciparum Ama-1 Protein And Uses Thereof
David Lanar - Takoma Park MD, US Sheetij Dutta - Silver Spring MD, US Lisa Ware - Silver Spring MD, US Lalitha Nair - Silver Spring MD, US
International Classification:
C07H021/02 C07H021/04
US Classification:
536/023100
Abstract:
In this application is described the expression and purification of a recombinant (3D7) AMA-1 ectodomain. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. The recombinant AMA-1 is useful as a diagnostic reagent, for use in antibody production, and as a vaccine.