Lloyd Louis Hollenbeck from 48 Pleasant Run Rd, Flemington, NJ 08822

Method Of Producing A Metal Sol Reagent Containing Colloidal Metal Particles
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US Patent:

55146023, May 7, 1996
Filed:

Feb 25, 1993
Appl. No.:

8/022544
Inventors:

Houston G. Brooks - Somerset NJ
Utpal R. Chakraborty - Flemington NJ
Henry A. Graham - Annandale NJ
Lloyd L. Hollenbeck - Flemington NJ
Sharon R. Lawler - Somerville NJ
Jennifer Nasser - Piscataway NJ
Ernest G. Schutt - Long Valley NJ
Albert Venturini - E. Stroudsburg PA
Assignee:

Ortho Diagnostic Systems, Inc. - Raritan NJ
International Classification:

G01N 33553
US Classification:

436525
Abstract:

A method and test kit useful in a wide variety of immunoassay systems. A method of producing metal sol reagents containing metal sol particles of a preselected size is provided. A metal containing solution is reduced under optimized pH conditions to produce metal sol particles of a preselected size, the particles are coated with a coupling compound and then bound with at least one selected immunochemically reactive component. Particles having different immunochemical specificities are also mixed to produce reagents having multiple selected immunochemical specificities.