Longbin B Liu

US Patent:

6583154, Jun 24, 2003

Filed:

Aug 16, 2000

Appl. No.:

09/640263

Inventors:

Mark Henry Norman - Thousand Oaks CA
Clarence R. Hurt - Camarillo CA
Ning Chen - Thousand Oaks CA
Christopher H. Fotsch - Thousand Oaks CA
Nianhe Han - Thousand Oaks CA
Tracy J. Jenkins - Simi Valley CA
Longbin Liu - Thousand Oaks CA
Ofir A. Moreno - Ventura CA

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 3144

US Classification:

514299, 546299

Abstract:

There are provided compounds, compositions and methods of use thereof in the modulation of feeding behavior, obesity, diabetes, cancer (tumor), inflammatory disorders, depression, stress related disorders, Alzheimers disease and other disease conditions.

US Patent:

6849639, Feb 1, 2005

Filed:

Dec 8, 2000

Appl. No.:

09/732546

Inventors:

Celia Dominguez - Thousand Oaks CA, US
Guoqing Chen - Thousand Oaks CA, US
Ning Xi - Thousand Oaks CA, US
Shimin Xu - Moorpark CA, US
Nianhe Han - Thousand Oaks CA, US
Qingyian Liu - Thousand Oaks CA, US
Qi Huang - Moorpark CA, US
Aaron Siegmund - Ventura CA, US
Michael Handley - Ventura CA, US
Longbin Liu - Thousand Oaks CA, US
Alexander Kiselyov - New York NY, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D40112
C07D40312
A61K 314025

US Classification:

514275, 514314, 514318, 514333, 514341, 514342, 514343, 514422, 514424, 544331, 544332, 546175, 546194, 546256, 5462707, 5462747, 5462784, 5483147, 548526, 548527, 548547, 548550

Abstract:

The invention comprises novel compounds that are effective in the prophylaxis and treatment of diseases, such as integrin receptors mediated diseases, in particular, diseases or conditions mediated by integrin receptors, such as a αβ, αβ, αβ, αβand the like. The invention encompasses novel compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of such diseases and disorders. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

US Patent:

7049318, May 23, 2006

Filed:

Jul 23, 2004

Appl. No.:

10/897884

Inventors:

Celia Dominguez - Thousand Oaks CA, US
Timothy Scot Harvey - Thousand Oaks CA, US
Longbin Liu - Thousand Oaks CA, US
Aaron Siegmund - Oxnard CA, US

Assignee:

AMGEN Inc. - Thousand Oaks CA

International Classification:

A61K 31/505

US Classification:

514269, 544242

Abstract:

The present invention relates to compounds having the general formula.

US Patent:

7429594, Sep 30, 2008

Filed:

Aug 20, 2004

Appl. No.:

10/923067

Inventors:

Longbin Liu - Thousand Oaks CA, US
Patricia Lopez - West Hills CA, US
Manoj Bajpai - Simi Valley CA, US
Aaron C. Siegmund - Ventura CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 401/04
A61K 31/519

US Classification:

5142591, 514272, 544279, 544321

Abstract:

The present invention relates to compounds having the general formula.

US Patent:

7504403, Mar 17, 2009

Filed:

Jan 21, 2005

Appl. No.:

11/041151

Inventors:

Michael J. Frohn - Thousand Oaks CA, US
Longbin Liu - Thousand Oaks CA, US
Patricia Lopez - West Hills CA, US
Aaron Siegmund - Ventura CA, US
Seifu Tadesse - Simi Valley CA, US
Nuria Tamayo - Newbury Park CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 487/04
A61K 31/506

US Classification:

5142591, 5142594, 51425941, 5142595, 544279, 544281, 544282

Abstract:

The present invention relates to pyrimidinones and pyridones and derivatives thereof, and pharmaceutically acceptable salts thereof. Also included is a method of treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.

US Patent:

7652009, Jan 26, 2010

Filed:

Nov 29, 2005

Appl. No.:

11/289659

Inventors:

Steven Bellon - Wellesley MA, US
Shon Booker - Thousand Oaks CA, US
Noel D'Angelo - Thousand Oaks CA, US
Celia Dominguez - Los Angeles CA, US
Ingrid Fellows - Fresno CA, US
Matthew Lee - Calabasas CA, US
Longbin Liu - Thousand Oaks CA, US
Elizabeth Rainbeau - Port Hueneme CA, US
Aaron C. Siegmund - Ventura CA, US
Andrew Tasker - Simi Valley CA, US
Ning Xi - Thousand Oaks CA, US
Yuan Cheng - Newbury Park CA, US

Assignee:

Amgem Inc. - Thousand Oaks CA

International Classification:

A61K 31/506
C07D 401/02
C07D 239/22

US Classification:

51425204, 514269, 544238, 544242, 544298, 544319

Abstract:

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

US Patent:

7820665, Oct 26, 2010

Filed:

Dec 18, 2008

Appl. No.:

12/317166

Inventors:

Shon Booker - Thousand Oaks CA, US
Hongyu Liao - Thousand Oaks CA, US
Longbin Liu - Thousand Oaks CA, US
Mark H. Norman - Thousand Oaks CA, US
Emily Anne Peterson - Cambridge MA, US
Markian Stec - Moorpark CA, US
Nuria A. Tamayo - Newbury Park CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 31/4188
A61K 31/5025
C07D 487/04

US Classification:

514248, 544236

Abstract:

The present invention relates to imidazopyridazine compounds of Formula I, such as representative structure A, or a pharmaceutically acceptable salt thereof, that inhibit phosphoinositide 3-kinase;.

US Patent:

7928140, Apr 19, 2011

Filed:

Aug 1, 2008

Appl. No.:

12/221416

Inventors:

Shon Booker - Thousand Oaks CA, US
Noel D'Angelo - Thousand Oaks CA, US
Derin C. D'Amico - Newbury Park CA, US
Longbin Liu - Thousand Oaks CA, US
Kristin Meagher - Thousand Oaks CA, US
Mark H. Norman - Thousand Oaks CA, US
Kathleen Panter - Cambridge MA, US
Laurie B. Schenkel - Boston MA, US
Adrian L. Smith - Simi Valley CA, US
Nuria A. Tamayo - Newbury Park CA, US
Douglas A. Whittington - Waltham MA, US
Ning Xi - Thousand Oaks CA, US
Kevin Yang - San Gabriel CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 31/38

US Classification:

514514, 544333, 544405, 5462811, 548143, 548161, 5483461

Abstract:

The present invention comprises a new class of compounds capable of modulating the activity of PI3 kinase and, accordingly, useful for treatment of PI3 kinase mediated diseases, including melanomas, carcinomas and other cancer-related conditions. The compounds have a general Formula I.