Lorraine G Scott

US Patent:

6673926, Jan 6, 2004

Filed:

Oct 29, 2001

Appl. No.:

10/021369

Inventors:

Lorraine Scott - North Wales PA
Donald G. Walker - Pipersville PA

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

C07D23902

US Classification:

544335, 546334, 546335

Abstract:

The present invention is directed to a process for preparing 3S-3-amino-3-aryl propionic acid and derivatives thereof.

US Patent:

20030176471, Sep 18, 2003

Filed:

Mar 27, 2003

Appl. No.:

10/401073

Inventors:

Lorraine Scott - North Wales PA, US
Donald Walker - Pipersville PA, US

International Classification:

C07D213/55
A61K031/44

US Classification:

514/357000, 546/335000

Abstract:

The present invention is directed to a process for preparing 3S-3-amino-3-aryl propionic acid and derivatives thereof.

US Patent:

20040063960, Apr 1, 2004

Filed:

Sep 25, 2003

Appl. No.:

10/671104

Inventors:

Lorraine Scott - North Wales PA, US
Frank Villani - Perkasie PA, US
Donald Walker - Pipersville PA, US

International Classification:

C07D213/55

US Classification:

546/335000

Abstract:

The present invention is directed to a process for preparing 3S-3-amino-3-aryl propionic acid and derivatives thereof.

US Patent:

20090233874, Sep 17, 2009

Filed:

Sep 9, 2008

Appl. No.:

12/207252

Inventors:

Ahmed F. Abdel-Magid - Ambler PA, US
Maureen Chisholm - Schwenksville PA, US
Steven Mehrman - Quakertown PA, US
Lorraine Scott - North Wales PA, US
Kenneth M. Wells - Hillsborough NJ, US
Sumihiro Nomura - Osaka, JP
Mitsuya Hongu - Osaka, JP
Yuichi Koga - Osaka, JP

International Classification:

A61K 31/706
C07H 7/06
A61P 3/10

US Classification:

514 23, 536122, 536 54

Abstract:

The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.

US Patent:

53877004, Feb 7, 1995

Filed:

Aug 12, 1993

Appl. No.:

8/106470

Inventors:

Cynthia A. Maryanoff - New Hope PA
Lorraine Scott - North Wales PA
Kirk L. Sorgi - Blue Bell PA

Assignee:

McNeilab, Inc. - Spring House PA

International Classification:

C07D31178
C07D31194
C07D30906
C07C30902

US Classification:

549387

Abstract:

A process for producing chlorosulfate and sulfamate esters of 2,3:4,5-bis-O-(1-methylethylidene)-. beta. -D-fructopyranose and (1-methylcyclohexyl)methanol is disclosed. The process involves a two step procedure involving in the first step reacting of an alcohol with sulfuryl chloride in the presence of a tertiary or heterocyclic amine base in a solvent selected from the group consisting of toluene, t-butyl methyl ether or tetrahydrofuran to produce a chlorosulfate intermediate, which is preferably stabilized by an aqueous wash and/or treatment with a base, and in the second step reacting of the resulting intermediate with an amine in a solvent selected from the group consisting of t-butyl methyl ether, tetrahydrofuran and lower alkanol.