Luis Adiel Gutierrez Calderon

US Patent:

20180208669, Jul 26, 2018

Filed:

Jun 15, 2015

Appl. No.:

15/319344

Inventors:

- Bethesda MD, US
- Spring House PA, US
Luis Espinoza Calderon - Bethesda MD, US
Kate Sasser - Spring House PA, US
Ricardo Attar - Spring House PA, US

Assignee:

The United States of America, as represented by th e Secretary, Dept. of Health and Human Services - Bethesda MD
Janssen Biotech, Inc. - Spring House PA

International Classification:

C07K 16/28
A61P 35/02
A61P 37/00

Abstract:

Provided herein are methods of inhibiting growth or proliferation of cells expressing CD38 by contacting the CD38-expressing cells with 1) NK cells bound to an anti-CD38 F(ab′)fragment and 2) an anti-CD38 antibody, in either order or simultaneously. Also provided herein are methods of treating or inhibiting a hyperproliferative disorder or an autoimmune disorder in a subject by administering to the subject 1) NK cells bound to an anti-CD38 F(ab′)fragment and 2) an anti-CD38 antibody, in either order or simultaneously.