Luis A Zuniga

US Patent:

20070286863, Dec 13, 2007

Filed:

May 4, 2007

Appl. No.:

11/800116

Inventors:

Christopher Sinal - Halifax, CA
Kerry Goralski - Halifax, CA
Tanya McCarthy - Halifax, CA
Luis Zuniga - Stanford CA, US
Brian Zabel - Mountain View CA, US
Eugene Butcher - Portola Valley CA, US

International Classification:

A61K 39/395
A61K 31/7052
A61P 3/00
G01N 33/53
A61K 38/08

US Classification:

424143100, 435375000, 435007200, 435007920, 514015000, 514044000

Abstract:

Methods are provided for regulating adipogenesis and metabolic function in adipocytes by modulating the activity of chemokine-like receptor 1 (CMKLR1). Exemplary agents include those that modulate binding of CMKLR1 to a cognate ligand (e.g., chemerin), those that modulate signaling from CMKLR1, and those that modulate expression of either CMKLR1 or its cognate ligand in target cells. Methods are also provided for screening for agents that find use in regulating fat accumulation in a subject.

US Patent:

20100092974, Apr 15, 2010

Filed:

Aug 13, 2009

Appl. No.:

12/541056

Inventors:

Brian A. Zabel - Redwood City CA, US
Eugene C. Butcher - Portola Valley CA, US
Stephen J. Galli - Stanford CA, US
Susumu Nakae - Machida, JP
Luis Zuniga - Palo Alto CA, US

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

The invention provides methods and compositions for identifying a modulator of CCRL2 and chemerin. The present invention also provides methods and compositions for treating an inflammatory disease by administering a compound that modulates the interaction of CCRL2 with chemerin.

US Patent:

60646861, May 16, 2000

Filed:

Mar 30, 1999

Appl. No.:

9/283898

Inventors:

Luis A. Zuniga - Grass Valley CA
Michael E. LaFrance - Columbia CA
Larry F. Willitzer - Rodeo CA
Christopher S. Johnson - Sunnyvale CA

Assignee:

TFI Telemark - Fremont CA

International Classification:

H01J 37305
B23K 1500

US Classification:

373 13

Abstract:

An electron gun that prevents undesirable arcing by providing an improved electrostatic field that generates a confined electron stream, an improved magnetic field that directs the confined electron stream to a crucible with minimal divergence, and an improved insulation on high voltage leads. The improved electrostatic field is provided by a cathode plate disposed adjacent to a filament and forming a cathode window aligned to the filament. An anode plate disposed adjacent to the cathode plate forms an anode window aligned to the cathode window. The cathode plate and anode plate form an electrostatic field and lensing effect that directs electrons emitted from the filament through the cathode and anode windows with minimal divergence. The improved magnetic field is provided by a magnet having a pair of poles, a pair of extension plates each extending from the magnet poles, and a plurality of extension members that extend from the extension plates toward the path of the electron stream. The magnet, pair of extension plates and plurality of extension members provide a uniform magnetic field along the electron stream path to guide the electron stream to the crucible with a minimum of divergence.