Dr. Zuniga graduated from the Univ Nac'l Auto De Honduras, Fac De Cien Med, Tegucigalpa, Honduras in 1975. He works in Catonsville, MD and specializes in Internal Medicine. Dr. Zuniga is affiliated with Howard County General Hospital and Saint Agnes Hospital.
Christopher Sinal - Halifax, CA Kerry Goralski - Halifax, CA Tanya McCarthy - Halifax, CA Luis Zuniga - Stanford CA, US Brian Zabel - Mountain View CA, US Eugene Butcher - Portola Valley CA, US
Methods are provided for regulating adipogenesis and metabolic function in adipocytes by modulating the activity of chemokine-like receptor 1 (CMKLR1). Exemplary agents include those that modulate binding of CMKLR1 to a cognate ligand (e.g., chemerin), those that modulate signaling from CMKLR1, and those that modulate expression of either CMKLR1 or its cognate ligand in target cells. Methods are also provided for screening for agents that find use in regulating fat accumulation in a subject.
Brian A. Zabel - Redwood City CA, US Eugene C. Butcher - Portola Valley CA, US Stephen J. Galli - Stanford CA, US Susumu Nakae - Machida, JP Luis Zuniga - Palo Alto CA, US
International Classification:
C12Q 1/68
US Classification:
435 6
Abstract:
The invention provides methods and compositions for identifying a modulator of CCRL2 and chemerin. The present invention also provides methods and compositions for treating an inflammatory disease by administering a compound that modulates the interaction of CCRL2 with chemerin.