Maciej J Czerwinski

US Patent:

20120301892, Nov 29, 2012

Filed:

May 25, 2012

Appl. No.:

13/481295

Inventors:

Maciej Czerwinski - Fairway KS, US
David Benjamin Buckley - Olathe KS, US
Faraz Kazmi - Olathe KS, US

Assignee:

XENOTECH LLC - Lenexa KS

International Classification:

C12Q 1/68
C12Q 1/25
C12Q 1/02

US Classification:

435 613, 435 29

Abstract:

A method of evaluating the effect of a xenobiotic on biomarkers, such as drug transporters and drug-metabolizing enzymes in hepatocytes is provided. The method comprises the formation of a xenobiotic-stimulated biological sample, such as whole blood, which contains a plurality of cytokines. A portion of xenobiotic-stimulated biological sample is cultured with hepatocytes. The hepatocytes are then analyzed to evaluate the activity of drug transporters and/or drug-metabolizing enzymes, or other biomarkers to determine the effect of the xenobiotic on drug metabolism in the hepatocytes.

US Patent:

20110105359, May 5, 2011

Filed:

Aug 30, 2010

Appl. No.:

12/871393

Inventors:

Maciej Czerwinski - Fairway KS, US

Assignee:

XENOTECH, LLC - Lenexa KS

International Classification:

C40B 30/06
C12N 5/02
C40B 40/02
C12M 1/00

US Classification:

506 10, 435374, 506 14, 4353071

Abstract:

The invention provides cryopreserved compositions of cells, wherein the compositions are advantageously in the form of self-sustaining bodies that can be individually handled and combined independently of a container, allowing for easy customization of the eventual pooled preparation. The invention also provides pre-pooled stacks of the self-sustaining cryopreserved compositions for eventual thawing to produce pooled preparations of cells. A mold and methods for forming the self-sustaining bodies are also provided. The invention is also concerned with methods of forming pooled preparations of cells using single-cryopreserved compositions of cells.

US Patent:

20170202214, Jul 20, 2017

Filed:

Apr 4, 2017

Appl. No.:

15/478733

Inventors:

- Kansas City KS, US
Maciej Czerwinski - Fairway KS, US

International Classification:

A01N 1/02
C12N 5/071

Abstract:

The invention provides cryopreserved compositions of cells, wherein the compositions are advantageously in the form of self-sustaining bodies that can be individually handled and combined independently of a container, allowing for easy customization of the eventual pooled preparation. The invention also provides pre-pooled stacks of the self-sustaining cryopreserved compositions for eventual thawing to produce pooled preparations of cells, and methods of creating the same.

US Patent:

20160000065, Jan 7, 2016

Filed:

Sep 16, 2015

Appl. No.:

14/856199

Inventors:

- Lenexa KS, US
Maciej Czerwinski - Fairway KS, US

International Classification:

A01N 1/02
C12N 5/071

Abstract:

The invention provides cryopreserved compositions of cells, wherein the compositions are advantageously in the form of self-sustaining bodies that can be individually handled and combined independently of a container, allowing for easy customization of the eventual pooled preparation. The invention also provides pre-pooled stacks of the self-sustaining cryopreserved compositions for eventual thawing to produce pooled preparations of cells. A mold and methods for forming the self-sustaining bodies are also provided. The invention is also concerned with methods of forming pooled preparations of cells using single-cryopreserved compositions of cells.