Mamta K Sangha

US Patent:

20120174239, Jul 5, 2012

Filed:

Oct 27, 2011

Appl. No.:

13/317754

Inventors:

Stephen Jay Anderson - The Woodlands TX, US
Jane Brennan - Edinburgh, GB
Frederic J. de Sauvage - Foster City CA, US
Zhiyong Ding - Longmont CO, US
Joel Edwards - The Woodlands TX, US
Nelda A. Fikes - Spring TX, US
Wenhu Huang - San Diego CA, US
Wenjun Ouyang - Foster City CA, US
Carolina Rangel - Houston TX, US
Mamta Sangha - Flagstaff AZ, US
Mary Jean Sparks - Magnolia TX, US
Joseph Trackey - The Woodlands TX, US
Melissa Vetter - Spring TX, US
Ching-Yun Wang - The Woodlands TX, US
Jessica Woodings - Longmont CO, US

International Classification:

G01N 21/64
G01N 23/083
C40B 30/04
G01N 33/53

US Classification:

800 3, 435 71, 435 792, 506 9

Abstract:

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO224, PRO9783, PRO1108, PRO34000, PRO240, PRO943, hu A33, PRO230, PRO178, PRO1199, PRO4333, PRO1336, PRO19598, PRO1083, hu TRPM2 or PRO1801 genes.Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

US Patent:

20070292438, Dec 20, 2007

Filed:

Dec 13, 2004

Appl. No.:

10/583466

Inventors:

Stephen Anderson - The Woodlands TX, US
Jane Brennan - Lothian Region, GB
Frederic de Sauvage - Foster City CA, US
Zhiyong Ding - Longmont CO, US
Joel Edwards - The Woodlands TX, US
Nelda Fikes - Spring TX, US
Wenhu Huang - San Diego CA, US
Wenjun Ouyang - Foster City CA, US
Carolina Rangel - Houston TX, US
Mamta Sangha - Tualatin OR, US
Mary Sparks - Magnolia TX, US
Joseph Trackey - The Woodlands TX, US
Melissa Vetter - Spring TX, US
Ching-Yun Wang - The Woodlands TX, US
Jessica Woodings - Longmont CO, US

International Classification:

A61K 39/395
C07K 16/00
C12N 5/00
C12N 5/06
C12Q 1/02
G01N 33/00

US Classification:

424172100, 435029000, 435325000, 435352000, 435375000, 530387100, 800003000

Abstract:

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO224, PRO9783, PRO1108, PRO34000, PRO240, PRO943, hu A33, PRO230, PRO178, PRO1199, PRO4333, PRO1336, PRO19598, PRO1083, hu TRPM2 or PRO1801 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.