Hsiri Therapeutics - IN since 2011
Research Scientist
Neurogen Corporation Dec 1999 - 2008
Research Fellow II
Intercardia, Inc. 1996 - 1999
Research Scientist
Education:
University of Notre Dame 1991 - 1995
Calcutta University, Kolkata
Master of Science, Masters
Rajabazar Science College
Master of Science, Masters
Jadavpur University
Doctorates, Doctor of Philosophy
Scottish Church College
Bachelors, Bachelor of Science
Skills:
Drug Discovery Drug Design Drug Development Chemistry Medicinal Chemistry Organic Chemistry Organic Synthesis Carbohydrate Chemistry Amino Acids/Peptides Gpcrs Neuroscience Pharmacology Pharmacokinetics Oncology Infection Analytical Chemistry Nmr Chromatography Molecular Modeling Data Analysis Dmpk Adme Biotechnology Lead Change Formulation Drug Delivery Cro Cro Management Nuclear Magnetic Resonance Pharmaceutical Industry Life Sciences High Performance Liquid Chromatography Drug Metabolism Parallel Synthesis Science
Languages:
English Bengali Hindi
Us Patents
1H-Pyrrolo [3,2-B] Pyridine-3-Carboxylic Acid Amines As Gabaa Receptor Ligands
George D. Maynard - Clinton CT Manuka Ghosh - Branford CT Christopher J. ODonnell - Mystic CT
Assignee:
Neurogen Corporation - Branford CT Pfizer, Inc. - New York NY
International Classification:
A61K 314965
US Classification:
514300, 51425502, 544405, 546113
Abstract:
Disclosed are 1H-Pyrrolo[3,2-b]pyridine-3-carboxylic acid amides that bind to the benzodiazepine site of GABA receptors. Such compounds can be used to modulate ligand binding to GABA receptors in vivo and in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals, and livestock animals.
Guiying Li - Branford CT, US John M. Peterson - Madison CT, US Pamela Albaugh - Carmel IN, US Kevin S. Currie - North Branford CT, US Guolin Cai - Thousand Oaks CA, US Linda M. Gustavson - Guilford CT, US Kyungae Lee - Guilford CT, US Alan Hutchison - Madison CT, US Vinod Singh - Kanpur, IN George D. Maynard - Clinton CT, US Jun Yuan - Guilford CT, US Ling Hong Xie - Guilford CT, US Manuka Ghosh - Branford CT, US Nian Liu - North Branford CT, US
This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAreceptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAreceptors in tissue sections.
Heteroaryl Substituted Fused Bicyclic Heteroaryl Compound As Gabaa Receptor Ligands
Alan Hutchison - Madison CT, US George Maynard - Clinton CT, US Pamela Albaugh - Carmel IN, US Linghong Xie - Guilford CT, US Jun Yuan - Guilford CT, US Scott Mitchell - East Haven CT, US Vinod Singh - Kanpur, IN Manuka Ghosh - Madison CT, US Guiying Li - Branford CT, US Nian Liu - North Branford CT, US
Assignee:
Neurogen Corporation - Branford CT
International Classification:
C07D471/04 C07D487/04 C07D513/04 A61K031/437
US Classification:
514256, 514300, 544333, 546121
Abstract:
This invention relates to heteroaryl substituted fused bicyclic heteroaryl compounds, such as heteroaryl substituted imidazopyridines, imidazopyrazines, imidazopyridizines, imidazopyrimidines, and imidazothiazoles, which may be described by Formula I or Formula II: The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAreceptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Processes for preparing compounds of Formula I and Formula II are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I or Formula II in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAreceptors in tissue sections.
Alan J. Hutchison - Madison CT, US Bertrand L. Chenard - Waterford CT, US James G. Tarrant - Hamden CT, US Guiying Li - Branford CT, US Manuka Ghosh - Madison CT, US George P. Luke - Clinton CT, US John M. Peterson - Durham CT, US Wallace C. Pringle - Guilford CT, US Mary-Margaret E. O'Donnell - Shelton CT, US Kyungae Lee - Newton MA, US Linda M. Gustavson - Ringoes NJ, US Dario Doller - Wallingford CT, US
Compounds of Formula I are provided, in which variables are as described herein:Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e. g. , receptor localization studies).
Guiying Li - Branford CT, US Pamela Albaugh - Carlsbad CA, US Kevin S. Currie - North Branford CT, US Guolin Cai - Thousand Oaks CA, US Linda M. Gustavson - Ringoes NJ, US Kyungae Lee - Newton MA, US Alan Hutchison - Madison CT, US George D. Maynard - Clinton CT, US Jun Yuan - Guilford CT, US Ling Hong Xie - Guilford CT, US Manuka Ghosh - Madison CT, US Nian Liu - Edison NJ, US George P. Luke - Clinton CT, US Scott Mitchell - East Haven CT, US Martin Patrick Allen - North Stonington CT, US Spiros Liras - Stonington CT, US
Assignee:
Neurogen Corporation - Branford CT
International Classification:
C07D 471/04 A61K 31/437
US Classification:
514303, 546118, 206570
Abstract:
This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula IThe invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAreceptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAreceptors in tissue sections.
George D. Maynard - Clinton CT, US Manuka Ghosh - Madison CT, US Jun Yuan - Guilford CT, US Kevin S. Currie - North Branford CT, US Scott Mitchell - East Haven CT, US Qin Guo - Branford CT, US He Zhao - Branford CT, US
Assignee:
Neurogen Corporation - Brandford CT
International Classification:
A01N 43/54 C07D 239/42 C07D 401/04 C07D 403/00
US Classification:
514256, 544295
Abstract:
4,5-disubstituted-2-arylpyrimidines of Formula I and Formula II are provided:.
Guiying Li - Branford CT, US Pamela Albaugh - Carmel IN, US Kevin S. Currie - North Branford CT, US Guolin Cai - Thousand Oaks CA, US Linda M. Gustavson - Guilford CT, US Kyungae Lee - Guilford CT, US Alan Hutchison - Madison CT, US George D. Maynard - Clinton CT, US Jun Yuan - Guilford CT, US Ling Hong Xie - Guilford CT, US Manuka Ghosh - Branford CT, US Nian Liu - North Branford CT, US George P. Luke - Clinton CT, US Scott Mitchell - East Haven CT, US Martin Patrick Allen - North Stonington CT, US Spiros Liras - Stonington CT, US
Assignee:
Neurogen Corporation - Branford CT
International Classification:
C07D 471/04 A61K 31/437
US Classification:
5142621, 544262, 544264, 544265, 544277, 5142632
Abstract:
This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I. The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAreceptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate.
Rajagopal Bakthavatchalam - Madison CT, US Scott M. Capitosti - Middletown CT, US Jianjun Xu - Branford CT, US Bertrand L. Chenard - Waterford CT, US Manuka Ghosh - Madison CT, US Charles A. Blum - Westbrook CT, US