Marc R Pelletier

US Patent:

20060003407, Jan 5, 2006

Filed:

Mar 17, 2005

Appl. No.:

11/084647

Inventors:

Paul Rennert - Holliston MA, US
Graham Farrington - Acton MA, US
John Eldredge - So. Chatham MA, US
Marc Pelletier - Jamaica Plain MA, US
Yen-Ming Hsu - Lexington MA, US

International Classification:

C07H 21/04
C12P 21/06
C07K 14/715

US Classification:

435069100, 435320100, 435325000, 530350000, 536023500

Abstract:

The present invention relates to improved methods for producing biologically active truncated APRIL ligand polypeptides and analogs thereof. The invention further relates to truncated APRIL ligand polypeptides and analogs thereof that retain a high biological activity and may be isolated in high yields, as well as the nucleotide sequences that encode the truncated APRIL ligand polypeptides and analogs thereof. The invention also relates to compositions of the biologically active truncated APRIL ligand polypeptides and analogs thereof. The invention further relates to the use of the biologically active truncated APRIL ligand polypeptides and analogs thereof in promoting cell proliferation.

US Patent:

20210146050, May 20, 2021

Filed:

Sep 4, 2020

Appl. No.:

17/013105

Inventors:

- Cambridge MA, US
Marc Pelletier - Cambridge MA, US

International Classification:

A61M 5/30

Abstract:

A needle-free injector monitors the compression of a gas bubble within a cartridge of injectate during operating of a plunger in a pre-injection phase. When the gas bubble becomes sufficiently compressed (e.g., at or near the equilibrium pressure during the piercing phase), the velocity of the plunger of the needle-free injector is changed to the piercing rate for delivery of the injectate to a target. By detecting the gas bubble compression prior to delivery of injectate in this manner, an injection stream can be controlled to more closely reproduce a target injection profile. For example, the integrator error for an injector control model can be mitigated, stream acceleration can be optimized/maximized, and overshoot in the injector response (e.g., stream velocity or plunger movement) can be minimized.