Margaret M Galvin

US Patent:

6479236, Nov 12, 2002

Filed:

May 5, 1999

Appl. No.:

09/305856

Inventors:

Laura Penny - San Diego CA
Margaret Galvin - Carlsbad CA

Assignee:

DNA Sciences Laboratories, Inc. - Morrisville NC

International Classification:

C07H 2104

US Classification:

435 6, 536 231, 536 243, 536 2431

Abstract:

Genetic polymorphisms are identified in the human UGT1 gene that alter UGT1-dependent drug metabolism. Nucleic acids comprising the polymorphic sequences are used to screen patients for altered metabolism for UGT1 substrates, potential drug-drug interactions, and adverse/side effects, as well as diseases that result from environmental or occupational exposure to toxins. The nucleic acids are used to establish animal, cell and in vitro models for drug metabolism.

US Patent:

6586175, Jul 1, 2003

Filed:

Jul 20, 1999

Appl. No.:

09/356806

Inventors:

Margaret Galvin - San Diego CA
Andrew Miller - San Mateo CA
Laura Penny - San Diego CA
Michael Riedy - San Diego CA

Assignee:

DNA Sciences Laboratories, Inc. - Morrisville NC

International Classification:

C07H 2104

US Classification:

435 6, 536 231, 536 2431, 435 912

Abstract:

Genetic polymorphisms are identified in the human UGT2B4, UGT2B7 and UGT2B15 genes that alter UGT2B activity. Nucleic acids comprising the polymorphic sequences are used to screen patients for altered metabolism for UGT2B substrates, potential drug-drug interactions, and adverse/side effects, as well as diseases that result from environmental or occupational exposure to toxins. The nucleic acids are used to establish animal, cell and in vitro models for drug metabolism.

US Patent:

20030077629, Apr 24, 2003

Filed:

Jul 24, 2002

Appl. No.:

10/205522

Inventors:

Margaret Galvin - San Diego CA, US
Andrew Miller - San Mateo CA, US
Laura Penny - San Diego CA, US
Michael Riedy - San Diego CA, US

Assignee:

DNA Sciences, Inc.

International Classification:

C12Q001/68
C07H021/04

US Classification:

435/006000, 536/024300

Abstract:

Genetic polymorphisms are identified in the human UGT2B4, UGT2B7 and UGT2B15 genes that alter UGT2B activity. Nucleic acids comprising the polymorphic sequences are used to screen patients for altered metabolism for UGT2B substrates, potential drug-drug interactions, and adverse/side effects, as well as diseases that result from environmental or occupational exposure to toxins. The nucleic acids are used to establish animal, cell and in vitro models for drug metabolism.

US Patent:

20030157517, Aug 21, 2003

Filed:

Sep 18, 2002

Appl. No.:

10/247159

Inventors:

Laura Penny - San Clemente CA, US
Margaret Galvin - Carlsbad CA, US

Assignee:

DNA Sciences Laboratories, Inc.

International Classification:

C12Q001/68
C07H021/04
C12M001/34

US Classification:

435/006000, 435/287200, 536/024300

Abstract:

Genetic polymorphisms are identified in the human UGT1 gene that alter UGT1-dependent drug metabolism. Nucleic acids comprising the polymorphic sequences are used to screen patients for altered metabolism for UGT1 substrates, potential drug-drug interactions, and adverse/side effects, as well as diseases that result from environmental or occupational exposure to toxins. The nucleic acids are used to establish animal, cell and in vitro models for drug metabolism.

US Patent:

60874856, Jul 11, 2000

Filed:

Jan 21, 1998

Appl. No.:

9/009913

Inventors:

Angela R. Brooks-Wilson - San Diego CA
Alan Buckler - Cardiff CA
Lon Cardon - San Diego CA
Alisoun H. Carey - San Diego CA
Margaret Galvin - Encinitas CA
Andrew Miller - San Diego CA
Michael North - San Diego CA

Assignee:

AxyS Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C07H 2104

US Classification:

536 235

Abstract:

A genetic locus associated with asthma is identified. The genes within the locus, ASTH1I and ASTH1J, and the regulatory sequences of the locus are characterized. The genes are used to produce the encoded proteins; in screening for compositions that modulate the expression or function of ASTH1 proteins; and in studying associated physiological pathways. The DNA is further used as a diagnostic for genetic predisposition to asthma.