Margaret C Taylor

US Patent:

20030083272, May 1, 2003

Filed:

Sep 18, 1998

Appl. No.:

09/156323

Inventors:

KRISTIN WIEDERHOLT - NATICK MA, US
Tod Woolf - Sudbury MA, US
Margaret Taylor - Hopkinton MA, US

Assignee:

LAHIVE & COCKFIELD, LLP

International Classification:

A61K048/00
C07H021/02

US Classification:

514/044000, 536/023100

Abstract:

The present invention describes novel methods for the stabilization of mRNA. These alterations increase stability of mRNA and enable its use in sense RNA therapy to transiantly express proteins in a cell. Accordingly, the present invention is directed to methods for making such modifications, compositions comprising such modifications, and the use of such compositions in treating disease states.

US Patent:

20040054155, Mar 18, 2004

Filed:

Oct 2, 2003

Appl. No.:

10/357826

Inventors:

Tod Woolf - Sudbury MA, US
Margaret Taylor - Hopkinton MA, US

Assignee:

Sequitur, Inc. - Natick MA

International Classification:

C07H019/00

US Classification:

536/022100

Abstract:

The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2 different oligonucleotides targeted to a target gene. This invention also provides methods of inhibiting protein synthesis in a cell and methods of identifying oligonucleotide compositions that inhibit synthesis of a protein in a cell.

US Patent:

20090043242, Feb 12, 2009

Filed:

Aug 7, 2007

Appl. No.:

11/835070

Inventors:

Eric A. Bene - Lynn MA, US
Michael J. McGraw - Brighton MA, US
Margaret Taylor - Groton MA, US
Mark Bowen - Stow MA, US
Ed Lee - Burlington MA, US

Assignee:

Becton, Dickinson and Company - Franklin Lakes NJ

International Classification:

A61M 27/00

US Classification:

604 8, 128898, 606108

Abstract:

A method of implanting a transcorneal shunt into a cornea, the shunt having a head and a foot, each having a hole therein, the method including the operations of engaging an insertion tool with a foot hole of the shunt; making an entry incision in the cornea; inserting the shunt, while still engaged with the insertion tool, through the entry incision; making an implant incision in the cornea; inserting the head of the shunt through the implant incision to position and seat the shunt; and releasing the shunt from the insertion tool.

US Patent:

20090093433, Apr 9, 2009

Filed:

Aug 1, 2008

Appl. No.:

12/185012

Inventors:

Tod Woolf - Natick MA, US
Kristin Wiederholt - Vista MA, US
Margaret Taylor - Hopkinton MA, US

Assignee:

INVITROGEN CORPORATION - Carlsbad CA

International Classification:

A61K 31/7105
C07H 21/02
C12P 19/34

US Classification:

514 44, 536 235, 435 911

Abstract:

The present invention describes novel methods for the stabilization of mRNA. These alterations increase stability of mRNA and enable its use in sense RNA therapy to transiantly express proteins in a cell. Accordingly, the present invention is directed to methods for making such modifications, compositions comprising such modifications, and the use of such compositions in treating disease states.

US Patent:

20090131848, May 21, 2009

Filed:

Nov 16, 2007

Appl. No.:

11/941150

Inventors:

Margaret Taylor - Groton MA, US

Assignee:

Becton, Dickinson and Company - Franklin Lakes NJ

International Classification:

A61M 1/00
A61F 9/01

US Classification:

604 8, 606166

Abstract:

A method for implanting a transcorneal implant having a cap, a foot, and a body connecting the cap and the foot, the body having a lesser circumference than either the cap or the foot, the method including the operations: creating a first corneal incision to create a tunnel, such that the a far end of the first incision enters the anterior chamber; creating a second corneal incision opening a roof of the tunnel to an end point past the far end of the first incision and creating flaps; guiding the implant to the end point, so that the foot of the implant is under the flaps; rotating the implant until the foot is entirely within the anterior chamber; and rotating the implant back to a neutral position, such that a portion of the foot is beneath a floor of the tunnel.

US Patent:

20100298408, Nov 25, 2010

Filed:

Dec 3, 2009

Appl. No.:

12/630523

Inventors:

Tod M. Woolf - Sudbury MA, US
Margaret F. Taylor - Hopkinton MA, US

Assignee:

LIFE TECHNOLOGY CORPORATION - Carlsbad CA

International Classification:

A61K 31/713
C07H 21/04
C12N 5/02
C12Q 1/68
A61P 35/00

US Classification:

514 44 A, 536 245, 435375, 435 6

Abstract:

The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2 different oligonucleotides targeted to a target gene. This invention also provides methods of inhibiting protein synthesis in a cell and methods of identifying oligonucleotide compositions that inhibit synthesis of a protein in a cell.

US Patent:

20120041373, Feb 16, 2012

Filed:

Aug 9, 2011

Appl. No.:

13/206438

Inventors:

Michel Bruehwiler - Newton MA, US
Cole Constantineau - Cambridge MA, US
Ryan Schoonmaker - San Marcos CA, US
James Bates - Sparta NJ, US
Margaret Taylor - Groton MA, US
Robert Banik - Long Valley NJ, US

International Classification:

A61M 5/32

US Classification:

604173

Abstract:

An apparatus is disclosed for storing and changing needles for connection with a medicament delivery device, comprising an inner housing, a reservoir disposed within the inner housing, and a needle holder disposed within the inner housing, for fluidly connecting a medicament container of the medicament delivery device with the reservoir. The apparatus also includes a plurality of patient needles displaceably disposed on the needle holder, and an outer housing displaceably disposed about the inner housing and providing a user interface to individually select one of the plurality of patient needles, connect the selected needle with the reservoir, expose the selected needle outside of the apparatus for injection, and store the selected needle.

US Patent:

20120041383, Feb 16, 2012

Filed:

Aug 9, 2011

Appl. No.:

13/206405

Inventors:

Michel Bruehwiler - Newton MA, US
Cole Constantineau - Cambridge MA, US
Ryan Schoonmaker - San Marcos CA, US
James Bates - Sparta NJ, US
Margaret Taylor - Groton MA, US
Robert Banik - Long Valley NJ, US

International Classification:

A61M 5/34
A61M 5/31
A61M 5/32

US Classification:

604192, 604240, 604200

Abstract:

An apparatus is disclosed for storing and changing needles for a medicament delivery device having a medicament container, including a fixed mount for connecting the apparatus with the medicament delivery device, a needle holder displaceable along a circuitous path and connecting a plurality of needles displaceably disposed thereon, and a guide member for guiding displacement of the needle holder, the guide member being disposed about the fixed mount. The apparatus also includes a user interface rotatably disposed about the fixed mount and having at least one internal engaging structure for displacing the needle holder along the circuitous path.